FATD_VIBA7
ID FATD_VIBA7 Reviewed; 314 AA.
AC P37738;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Ferric-anguibactin transport system permease protein FatD {ECO:0000305};
GN Name=fatD {ECO:0000303|PubMed:1748657};
OS Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum).
OG Plasmid pJM1.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=882102;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE, FUNCTION, AND
RP SUBUNIT.
RC STRAIN=ATCC 68554 / 775;
RX PubMed=1748657; DOI=10.1016/s0021-9258(18)54358-1;
RA Koester W.L., Actis L.A., Waldbeser L.S., Tolmasky M.E., Crosa J.H.;
RT "Molecular characterization of the iron transport system mediated by the
RT pJM1 plasmid in Vibrio anguillarum 775.";
RL J. Biol. Chem. 266:23829-23833(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 68554 / 775;
RX PubMed=13129954; DOI=10.1128/jb.185.19.5822-5830.2003;
RA Di Lorenzo M., Stork M., Tolmasky M.E., Actis L.A., Farrell D., Welch T.J.,
RA Crosa L.M., Wertheimer A.M., Chen Q., Salinas P., Waldbeser L., Crosa J.H.;
RT "Complete sequence of virulence plasmid pJM1 from the marine fish pathogen
RT Vibrio anguillarum strain 775.";
RL J. Bacteriol. 185:5822-5830(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 68554 / 775;
RX PubMed=21576332; DOI=10.1128/iai.05138-11;
RA Naka H., Dias G.M., Thompson C.C., Dubay C., Thompson F.L., Crosa J.H.;
RT "Complete genome sequence of the marine fish pathogen Vibrio anguillarum
RT harboring the pJM1 virulence plasmid and genomic comparison with other
RT virulent strains of V. anguillarum and V. ordalii.";
RL Infect. Immun. 79:2889-2900(2011).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 68554 / 775;
RX PubMed=21304833; DOI=10.1111/j.1758-2229.2009.00110.x;
RA Naka H., Lopez C.S., Crosa J.H.;
RT "Role of the pJM1 plasmid-encoded transport proteins FatB, C and D in
RT ferric anguibactin uptake in the fish pathogen Vibrio anguillarum.";
RL Environ. Microbiol. Rep. 2:104-111(2010).
CC -!- FUNCTION: Involved in the uptake of iron in complex with the
CC siderophore anguibactin. Responsible for the translocation of ferric-
CC anguibactin across the cytoplasmic membrane.
CC {ECO:0000269|PubMed:1748657, ECO:0000269|PubMed:21304833}.
CC -!- SUBUNIT: Part of an iron transport system composed of the outer
CC membrane receptor FatA, the periplasmic binding protein FatB and the
CC inner membrane proteins FatC and FatD. {ECO:0000305|PubMed:1748657}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mutants cannot transport ferric-anguibactin and
CC are unable to grow under iron-limiting conditions.
CC {ECO:0000269|PubMed:1748657, ECO:0000269|PubMed:21304833}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000305}.
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DR EMBL; AY312585; AAR12524.1; -; Genomic_DNA.
DR PIR; A41671; A41671.
DR RefSeq; NP_943549.1; NC_005250.1.
DR RefSeq; WP_011154635.1; NC_005250.1.
DR AlphaFoldDB; P37738; -.
DR SMR; P37738; -.
DR eggNOG; COG4606; Bacteria.
DR OMA; YLYAHRF; -.
DR Proteomes; UP000006800; Plasmid pJM1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3470.10; -; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Plasmid; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..314
FT /note="Ferric-anguibactin transport system permease protein
FT FatD"
FT /id="PRO_0000060014"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 314 AA; 33923 MW; FF78DCD58FDBAC88 CRC64;
MTFRMILAFF TLCATSLFFG ANQIEWSLLP TFNEKAWLPI IASRLPRLVA LILTGSGLAM
CGVILQHIVR NRFVEPGTTG SLDAAKLGIL VSIVMLPSSD KLERMFFAVL FCFAAGLVYI
AIIRKVKFSN TALVPVIGLM FGSVLSALAE FYAYQNNILQ SMSGWLMGDF SKVVQEHYEI
IFLILPITLL TYLYAHRFTV MGMGEDIASN LGISYAMTAA LGLILVSITV AVTVVTVGAI
HFVGLVIPNL VALKYGDHLK NTLPIVALGG ASLLIFCDVI SRVVLFPFEV PVGLTASAVG
GVMFLAFLLK GAKA
