ID   FATE1_BOVIN             Reviewed;         180 AA.
AC   Q95LA0; Q32LC8;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Fetal and adult testis-expressed transcript protein homolog;
GN   Name=FATE1; Synonyms=FATE;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Olesen C., Harboe T.L.;
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the regulation of endoplasmic reticulum (ER)-
CC       mitochondria coupling. Negatively regulates the ER-mitochondria
CC       distance and Ca(2+) transfer from ER to mitochondria possibly
CC       implicating it in the regulation of apoptosis. May collaborate with
CC       RNF183 to restrain BIK protein levels thus regulating apoptotic
CC       signaling. {ECO:0000250|UniProtKB:Q969F0}.
CC   -!- SUBUNIT: Interacts with BIK and RNF183. Interacts with IMMT/MIC60and
CC       EMD. {ECO:0000250|UniProtKB:Q969F0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q969F0}.
CC       Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q969F0}.
CC       Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q969F0}; Single-
CC       pass membrane protein {ECO:0000250|UniProtKB:Q8CEK7}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q969F0}. Note=Localized to specific membrane
CC       structures termed mitochondria-associated membranes (MAMs) which
CC       connect the endoplasmic reticulum (ER) and the mitochondria. Also
CC       associated with the outer surface of mitochondria at sites that are not
CC       in close contact with the ER. {ECO:0000250|UniProtKB:Q969F0}.
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DR   EMBL; AF387304; AAL30169.1; -; mRNA.
DR   EMBL; BC109644; AAI09645.1; -; mRNA.
DR   RefSeq; NP_776477.1; NM_174052.2.
DR   AlphaFoldDB; Q95LA0; -.
DR   SMR; Q95LA0; -.
DR   STRING; 9913.ENSBTAP00000008963; -.
DR   PaxDb; Q95LA0; -.
DR   PRIDE; Q95LA0; -.
DR   Ensembl; ENSBTAT00000008963; ENSBTAP00000008963; ENSBTAG00000006820.
DR   GeneID; 281153; -.
DR   KEGG; bta:281153; -.
DR   CTD; 89885; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006820; -.
DR   VGNC; VGNC:28878; FATE1.
DR   eggNOG; ENOG502SRT6; Eukaryota.
DR   GeneTree; ENSGT00390000006832; -.
DR   HOGENOM; CLU_129363_0_0_1; -.
DR   InParanoid; Q95LA0; -.
DR   OMA; MEHGSQS; -.
DR   OrthoDB; 1420413at2759; -.
DR   TreeFam; TF338514; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000006820; Expressed in spermatocyte and 21 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0051562; P:negative regulation of mitochondrial calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR039153; FATE1.
DR   InterPro; IPR039433; Mff-like_dom.
DR   PANTHER; PTHR21128; PTHR21128; 1.
DR   Pfam; PF05644; Miff; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Endoplasmic reticulum; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..180
FT                   /note="Fetal and adult testis-expressed transcript protein
FT                   homolog"
FT                   /id="PRO_0000087199"
FT   TRANSMEM        160..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          77..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   180 AA;  20360 MW;  0B53DF094F47A855 CRC64;
     MAGGAVPNLK EKMQVPKDED LLLGSFRDNQ ECSVAAEMKE HMSRLLGASQ RRQRVDPKAV
     GSAVVWNTAA NQSKKMGPQL RGVGVVGEQG DGGAQPQENP GGSQGMRSQF ERRELNTLAE
     IGLEELNELE MEIMRRQLFM ITERLRYLED QSATWHQREV LLFTMLLSSC ITNLWLWMRQ