FATE1_MOUSE
ID FATE1_MOUSE Reviewed; 99 AA.
AC Q8CEK7; Q14BM4;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Fetal and adult testis-expressed transcript protein homolog;
GN Name=Fate1; Synonyms=Fate;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in the regulation of endoplasmic reticulum (ER)-
CC mitochondria coupling. Negatively regulates the ER-mitochondria
CC distance and Ca(2+) transfer from ER to mitochondria possibly
CC implicating it in the regulation of apoptosis. May collaborate with
CC RNF183 to restrain BIK protein levels thus regulating apoptotic
CC signaling. {ECO:0000250|UniProtKB:Q969F0}.
CC -!- SUBUNIT: Interacts with BIK and RNF183. Interacts with IMMT/MIC60and
CC EMD. {ECO:0000250|UniProtKB:Q969F0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q969F0}.
CC Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q969F0}.
CC Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q969F0}; Single-
CC pass membrane protein {ECO:0000305}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q969F0}. Note=Localized to specific membrane
CC structures termed mitochondria-associated membranes (MAMs) which
CC connect the endoplasmic reticulum (ER) and the mitochondria. Also
CC associated with the outer surface of mitochondria at sites that are not
CC in close contact with the ER. {ECO:0000250|UniProtKB:Q969F0}.
CC -!- CAUTION: The human, porcine and bovine orthologs have a longer N-
CC terminal part. {ECO:0000305}.
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DR EMBL; AK020359; BAC25625.1; -; mRNA.
DR EMBL; AL731693; CAM46056.1; -; Genomic_DNA.
DR EMBL; BC115733; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q8CEK7; -.
DR STRING; 10090.ENSMUSP00000065715; -.
DR PaxDb; Q8CEK7; -.
DR PRIDE; Q8CEK7; -.
DR Antibodypedia; 30697; 313 antibodies from 22 providers.
DR Ensembl; ENSMUST00000066116; ENSMUSP00000065715; ENSMUSG00000053593.
DR Ensembl; ENSMUST00000114569; ENSMUSP00000110216; ENSMUSG00000053593.
DR UCSC; uc009tkj.2; mouse.
DR MGI; MGI:1925155; Fate1.
DR VEuPathDB; HostDB:ENSMUSG00000053593; -.
DR eggNOG; ENOG502SRT6; Eukaryota.
DR GeneTree; ENSGT00390000006832; -.
DR HOGENOM; CLU_2319587_0_0_1; -.
DR InParanoid; Q8CEK7; -.
DR OMA; LANLWLW; -.
DR PhylomeDB; Q8CEK7; -.
DR TreeFam; TF338514; -.
DR PRO; PR:Q8CEK7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8CEK7; protein.
DR Bgee; ENSMUSG00000053593; Expressed in secondary oocyte and 4 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0051562; P:negative regulation of mitochondrial calcium ion concentration; ISO:MGI.
DR InterPro; IPR039153; FATE1.
DR PANTHER; PTHR21128; PTHR21128; 1.
PE 3: Inferred from homology;
KW Apoptosis; Endoplasmic reticulum; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..99
FT /note="Fetal and adult testis-expressed transcript protein
FT homolog"
FT /id="PRO_0000087201"
FT TRANSMEM 79..98
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 99 AA; 11726 MW; B93FFF5AD09B2824 CRC64;
MPWVPREHSH DDVQLQEFSR NFPVGRFPYE CLEADIMAKI GLEELNGLEM EVMRRQMQMT
SGRLHILEDQ DATWCHKEAA LFTLLVSVCI ANLWLWVHW
