ID   FATE1_PIG               Reviewed;         171 AA.
AC   Q95LB4;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Fetal and adult testis-expressed transcript protein homolog;
GN   Name=FATE1; Synonyms=FATE;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11694338; DOI=10.1016/s0303-7207(01)00666-9;
RA   Olesen C., Larsen N.J., Byskov A.G., Harboe T.L., Tommerup N.;
RT   "Human FATE is a novel X-linked gene expressed in fetal and adult testis.";
RL   Mol. Cell. Endocrinol. 184:25-32(2001).
CC   -!- FUNCTION: Involved in the regulation of endoplasmic reticulum (ER)-
CC       mitochondria coupling. Negatively regulates the ER-mitochondria
CC       distance and Ca(2+) transfer from ER to mitochondria possibly
CC       implicating it in the regulation of apoptosis. May collaborate with
CC       RNF183 to restrain BIK protein levels thus regulating apoptotic
CC       signaling. {ECO:0000250|UniProtKB:Q969F0}.
CC   -!- SUBUNIT: Interacts with BIK and RNF183. Interacts with IMMT/MIC60and
CC       EMD. {ECO:0000250|UniProtKB:Q969F0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q969F0}.
CC       Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q969F0}.
CC       Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q969F0}; Single-
CC       pass membrane protein {ECO:0000250|UniProtKB:Q8CEK7}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q969F0}. Note=Localized to specific membrane
CC       structures termed mitochondria-associated membranes (MAMs) which
CC       connect the endoplasmic reticulum (ER) and the mitochondria. Also
CC       associated with the outer surface of mitochondria at sites that are not
CC       in close contact with the ER. {ECO:0000250|UniProtKB:Q969F0}.
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DR   EMBL; AF345986; AAL27184.1; -; mRNA.
DR   RefSeq; NP_998962.1; NM_213797.1.
DR   AlphaFoldDB; Q95LB4; -.
DR   SMR; Q95LB4; -.
DR   Ensembl; ENSSSCT00000062322; ENSSSCP00000047449; ENSSSCG00000039345.
DR   Ensembl; ENSSSCT00025077962; ENSSSCP00025033796; ENSSSCG00025056999.
DR   Ensembl; ENSSSCT00030073673; ENSSSCP00030033720; ENSSSCG00030052809.
DR   Ensembl; ENSSSCT00040099047; ENSSSCP00040044316; ENSSSCG00040072009.
DR   Ensembl; ENSSSCT00045059435; ENSSSCP00045041663; ENSSSCG00045034686.
DR   Ensembl; ENSSSCT00050053053; ENSSSCP00050022283; ENSSSCG00050039321.
DR   Ensembl; ENSSSCT00055041451; ENSSSCP00055032992; ENSSSCG00055021107.
DR   Ensembl; ENSSSCT00060037406; ENSSSCP00060015918; ENSSSCG00060027629.
DR   Ensembl; ENSSSCT00070009274; ENSSSCP00070007611; ENSSSCG00070004900.
DR   GeneID; 396705; -.
DR   KEGG; ssc:396705; -.
DR   CTD; 89885; -.
DR   VGNC; VGNC:88020; FATE1.
DR   GeneTree; ENSGT00390000006832; -.
DR   InParanoid; Q95LB4; -.
DR   OMA; MEHGSQS; -.
DR   OrthoDB; 1420413at2759; -.
DR   Proteomes; UP000008227; Chromosome X.
DR   Proteomes; UP000314985; Unassembled WGS sequence.
DR   Bgee; ENSSSCG00000039345; Expressed in testis and 3 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0051562; P:negative regulation of mitochondrial calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR039153; FATE1.
DR   InterPro; IPR039433; Mff-like_dom.
DR   PANTHER; PTHR21128; PTHR21128; 1.
DR   Pfam; PF05644; Miff; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Endoplasmic reticulum; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..171
FT                   /note="Fetal and adult testis-expressed transcript protein
FT                   homolog"
FT                   /id="PRO_0000087202"
FT   TRANSMEM        151..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          68..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   171 AA;  19065 MW;  E971DAB18A899C2D CRC64;
     MAGGSTNTKK IEMSLAEELV PKSQEPSREQ VLIAEMLEHG IRSLGASQSR QKLDSKISDS
     AAAWNLAANK SKKTGPQLPP KKASQEPNQE GGFQGMGFLY ERNLGADVIA EIGLEELNGL
     EMEIMRRQLQ VITGRLRALE DQGATWRHRE TLFFTMLVSV CVANLWLWLR Q