ID   FATRP_MYCTU             Reviewed;         631 AA.
AC   P9WQJ3; L0T955; P63397; Q11047;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Fatty acid ABC transporter ATP-binding/permease protein {ECO:0000305};
DE            EC=7.6.2.- {ECO:0000305|PubMed:29360453};
GN   OrderedLocusNames=Rv1272c; ORFNames=MTCY50.10;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [3]
RP   FUNCTION IN FATTY ACID IMPORT, AND DOMAIN.
RC   STRAIN=H37Rv;
RX   PubMed=29360453; DOI=10.1016/j.bbrc.2018.01.115;
RA   Martin A., Daniel J.;
RT   "The ABC transporter Rv1272c of Mycobacterium tuberculosis enhances the
RT   import of long-chain fatty acids in Escherichia coli.";
RL   Biochem. Biophys. Res. Commun. 496:667-672(2018).
CC   -!- FUNCTION: ABC transporter involved in fatty acid import
CC       (PubMed:29360453). Transmembrane domains (TMD) form a pore in the
CC       membrane and the ATP-binding domain (NBD) is responsible for energy
CC       generation (Probable). {ECO:0000269|PubMed:29360453,
CC       ECO:0000305|PubMed:29360453}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- DOMAIN: The ATP-binding domain (NBD) and the transmembrane domain (TMD)
CC       are fused. {ECO:0000305|PubMed:29360453}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Lipid exporter
CC       (TC 3.A.1.106) family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44028.1; -; Genomic_DNA.
DR   PIR; H70754; H70754.
DR   RefSeq; NP_215788.1; NC_000962.3.
DR   RefSeq; WP_003406569.1; NZ_NVQJ01000030.1.
DR   AlphaFoldDB; P9WQJ3; -.
DR   SMR; P9WQJ3; -.
DR   STRING; 83332.Rv1272c; -.
DR   PaxDb; P9WQJ3; -.
DR   DNASU; 887021; -.
DR   GeneID; 887021; -.
DR   KEGG; mtu:Rv1272c; -.
DR   TubercuList; Rv1272c; -.
DR   eggNOG; COG1132; Bacteria.
DR   OMA; WGTYLVK; -.
DR   PhylomeDB; P9WQJ3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1560.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF90123; SSF90123; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Reference proteome; Translocase; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..631
FT                   /note="Fatty acid ABC transporter ATP-binding/permease
FT                   protein"
FT                   /id="PRO_0000093261"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          42..365
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          397..631
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         430..437
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   631 AA;  68305 MW;  7B7A2D5E91AD06ED CRC64;
     MTAPPGARPR AASPPPNMRS RDFWGSAARL VKRLAPQRRL SIAVITLGIA GTTIGVIVPR
     ILGHATDLLF NGVIGRGLPG GITKAQAVAS ARARGDNTFA DLLSGMNVVP GQGVDFAAVE
     RTLALALALY LAAALMIWAQ ARLLNLTVQK TMVRLRTDVE DKVHRLPLSY FDGQQRGELL
     SRVTNDIDNL QSSLSMTISQ LVTSILTMVA VLAMMVSISG LLALITLLTV PLSLLVTRAI
     TRRSQPLFVA HWTSTGRLNA HLEETYSGFT VVKTFGHQAA ARERFHELND DVYQAGFGAQ
     FLSGLVQPAT AFIGNLGYVA VAVAGGLQVA TGQITLGSIQ AFIQYIRQFN MPLSQLAGMY
     NALQSGVASA ERVFDVLDEP EESPEPEPEL PNLTGRVEFE HVNFAYLPGT PVIRDLSLVA
     EPGSTVAIVG PTGAGKTTLV NLLMRFYEIG SGRILIDGVD IASVSRQSLR SRIGMVLQDT
     WLYDGTIAEN IAYGRPEATT DEIVEAARAA HVDRFVNTLP AGYQTRVSGD GGSISVGEKQ
     LITIARAFLA RPQLLILDEA TSSVDTRTEL LIQRAMRELR RDRTSFIIAH RLSTIRDADH
     ILVVQTGQIV ERGNHAELLA RRGVYYQMTR A