ID   FATR_BACSU              Reviewed;         194 AA.
AC   O08335; Q795Y6;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=HTH-type transcriptional repressor FatR {ECO:0000305};
DE   AltName: Full=Fatty acid displaced transcriptional repressor {ECO:0000303|PubMed:11734890};
GN   Name=fatR {ECO:0000303|PubMed:11734890};
GN   Synonyms=bscR {ECO:0000303|PubMed:11574077},
GN   yrhI {ECO:0000303|PubMed:11574077, ECO:0000312|EMBL:AAB80866.1};
GN   OrderedLocusNames=BSU27170;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9308178; DOI=10.1099/00221287-143-9-2939;
RA   Sorokin A., Bolotin A., Purnelle B., Hilbert H., Lauber J.,
RA   Duesterhoeft A., Ehrlich S.D.;
RT   "Sequence of the Bacillus subtilis genome region in the vicinity of the lev
RT   operon reveals two new extracytoplasmic function RNA polymerase sigma
RT   factors SigV and SigZ.";
RL   Microbiology 143:2939-2943(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RC   STRAIN=168;
RX   PubMed=11574077; DOI=10.1093/oxfordjournals.jbchem.a003020;
RA   Lee T.-R., Hsu H.-P., Shaw G.-C.;
RT   "Transcriptional regulation of the Bacillus subtilis bscR-CYP102A3 operon
RT   by the BscR repressor and differential induction of cytochrome CYP102A3
RT   expression by oleic acid and palmitate.";
RL   J. Biochem. 130:569-574(2001).
RN   [4]
RP   FUNCTION.
RC   STRAIN=168 / 1A1;
RX   PubMed=11734890; DOI=10.1007/s002030100350;
RA   Gustafsson M.C., Palmer C.N., Wolf C.R., von Wachenfeldt C.;
RT   "Fatty-acid-displaced transcriptional repressor, a conserved regulator of
RT   cytochrome P450 102 transcription in Bacillus species.";
RL   Arch. Microbiol. 176:459-464(2001).
RN   [5]
RP   REVIEW, AND GENE FAMILY.
RX   PubMed=15944459; DOI=10.1128/mmbr.69.2.326-356.2005;
RA   Ramos J.L., Martinez-Bueno M., Molina-Henares A.J., Teran W., Watanabe K.,
RA   Zhang X., Gallegos M.T., Brennan R., Tobes R.;
RT   "The TetR family of transcriptional repressors.";
RL   Microbiol. Mol. Biol. Rev. 69:326-356(2005).
CC   -!- FUNCTION: Negatively regulates the transcription of the fatR-cypB
CC       operon. Is displaced from its operator by a range of fatty acids such
CC       as oleate, linoleate and phytanate, thereby allowing transcription of
CC       the fatR-cypB operon. {ECO:0000269|PubMed:11574077,
CC       ECO:0000269|PubMed:11734890}.
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DR   EMBL; U93874; AAB80866.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14659.1; -; Genomic_DNA.
DR   PIR; H69974; H69974.
DR   RefSeq; NP_390595.1; NC_000964.3.
DR   RefSeq; WP_009967878.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O08335; -.
DR   SMR; O08335; -.
DR   IntAct; O08335; 1.
DR   STRING; 224308.BSU27170; -.
DR   PaxDb; O08335; -.
DR   PRIDE; O08335; -.
DR   DNASU; 938491; -.
DR   EnsemblBacteria; CAB14659; CAB14659; BSU_27170.
DR   GeneID; 938491; -.
DR   KEGG; bsu:BSU27170; -.
DR   PATRIC; fig|224308.179.peg.2950; -.
DR   eggNOG; COG1309; Bacteria.
DR   InParanoid; O08335; -.
DR   OMA; YCLIDFT; -.
DR   PhylomeDB; O08335; -.
DR   BioCyc; BSUB:BSU27170-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR032551; BscR_C.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF16295; TetR_C_10; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..194
FT                   /note="HTH-type transcriptional repressor FatR"
FT                   /id="PRO_0000360616"
FT   DOMAIN          6..66
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        29..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   194 AA;  22214 MW;  6BA3D3CA16345D58 CRC64;
     MISASSSKYD MIMKASVSLF TERGFDATTI PMIAERAHVG TGTIYRYFDS KETLVNVLFQ
     ESIQRFTEKL KQDVSELPVR EGFHHVFCCL VQFTKESDYA LFFLETKKDA HYLNHTSKKM
     IENLTQMLDD YFNKGKAEGV IRSLPSNVLI AIVLGAFLKI YQLVQTGDIE MDTDLITELE
     QCCWDAIKLH SSQK