FAU1_PYRHO
ID FAU1_PYRHO Reviewed; 469 AA.
AC O57857;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Probable ribonuclease FAU-1 {ECO:0000255|HAMAP-Rule:MF_01910};
DE EC=3.1.26.- {ECO:0000255|HAMAP-Rule:MF_01910};
DE AltName: Full=RNA-binding protein FAU-1 {ECO:0000255|HAMAP-Rule:MF_01910};
GN Name=fau-1 {ECO:0000255|HAMAP-Rule:MF_01910}; OrderedLocusNames=PH0117;
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
CC -!- FUNCTION: Probable RNase involved in rRNA stability through maturation
CC and/or degradation of precursor rRNAs. Binds to RNA in loop regions
CC with AU-rich sequences. {ECO:0000255|HAMAP-Rule:MF_01910}.
CC -!- SIMILARITY: Belongs to the FAU-1 family. {ECO:0000255|HAMAP-
CC Rule:MF_01910}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA29186.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BA000001; BAA29186.1; ALT_INIT; Genomic_DNA.
DR PIR; C71232; C71232.
DR RefSeq; WP_048053036.1; NC_000961.1.
DR AlphaFoldDB; O57857; -.
DR SMR; O57857; -.
DR STRING; 70601.3256503; -.
DR EnsemblBacteria; BAA29186; BAA29186; BAA29186.
DR GeneID; 1444015; -.
DR KEGG; pho:PH0117; -.
DR eggNOG; arCOG04307; Archaea.
DR OrthoDB; 83570at2157; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0016891; F:endoribonuclease activity, producing 5'-phosphomonoesters; IEA:UniProtKB-UniRule.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.380.10; -; 1.
DR HAMAP; MF_01910; RNA_binding_AU_1; 1.
DR InterPro; IPR007295; DUF402.
DR InterPro; IPR035930; FomD-like_sf.
DR InterPro; IPR019307; RNA-bd_AU-1/RNase_E/G.
DR InterPro; IPR016730; RNA-bd_FAU-1.
DR InterPro; IPR022967; S1_dom.
DR Pfam; PF04167; DUF402; 1.
DR Pfam; PF10150; RNase_E_G; 1.
DR PIRSF; PIRSF018644; RNA-binding_FAU-1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF159234; SSF159234; 1.
PE 3: Inferred from homology;
KW Endonuclease; Hydrolase; Nuclease; RNA-binding; rRNA processing.
FT CHAIN 1..469
FT /note="Probable ribonuclease FAU-1"
FT /id="PRO_0000334208"
SQ SEQUENCE 469 AA; 53793 MW; D245CF1300901D6C CRC64;
MSTESEISVR IRGIYSTALT KLLLDKGFKI VQPSDIIAER LGLEKSYEDF DIDIYDRNHG
ITVVGTKVEE IRKVLEEELI DVFFRKLPYK LYGVYKGIVV KRDDRYVYVD IGNAIGTVLI
EELPDATEGD EVIVQVKKHN VLPHLSVLIT IPGDYAVLIP KPIGVQRHVK ISRKIRDPEE
RERLRILGLS VNLGEWGILW RTAAAYKEWS VLRDEIVRLS KVADKLKEAE KYSAPAEIIE
GRNIYEIEFG GGAKKKLDEI RNKVVPTIEG HHQYKSYDPE FTLAVEVAEG ILAKMPSQRQ
KISEGFIEAI VNSKGPKLGW MFTLNHVKPD GQVIKIGPGE VIEVSVKPLK VKIRRNLKPG
RVYDGLEVPI EPGDYAITEI EAGKWWFVHR YYDRNGNLKG EFYNINTPVE IYPDKARYID
LEVDIVKWPD GKKEIIDKEK LKEHYEDGII SEKLYKSVLR IVQEIYEKV
