FAU_DROME
ID FAU_DROME Reviewed; 131 AA.
AC C0HK95; Q95S18; Q9VGX1; Q9VGX2; Q9VGX3; Q9Y0F9;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2016, sequence version 1.
DT 03-AUG-2022, entry version 26.
DE RecName: Full=Protein anoxia up-regulated {ECO:0000303|PubMed:9878744};
GN Name=fau {ECO:0000303|PubMed:9878744, ECO:0000312|FlyBase:FBgn0266451};
GN ORFNames=CG45077 {ECO:0000312|FlyBase:FBgn0266451};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=Canton-S; TISSUE=Head;
RX PubMed=9878744; DOI=10.1016/s0169-328x(98)00265-4;
RA Ma E., Xu T., Haddad G.G.;
RT "Gene regulation by O2 deprivation: an anoxia-regulated novel gene in
RT Drosophila melanogaster.";
RL Brain Res. Mol. Brain Res. 63:217-224(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Plays an important role in the regulation of tissue
CC responsiveness to oxygen deprivation. {ECO:0000269|PubMed:9878744}.
CC -!- TISSUE SPECIFICITY: Concentrated in lamina neurons, first optic lobe
CC neurons and cortical neurons of central brain.
CC {ECO:0000269|PubMed:9878744}.
CC -!- INDUCTION: By anoxia. {ECO:0000269|PubMed:9878744}.
CC -!- MISCELLANEOUS: 'fau' is an acronym for 'fly, anoxia, up-regulated'.
CC {ECO:0000303|PubMed:9878744}.
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DR EMBL; AF154418; AAD38397.1; -; mRNA.
DR EMBL; AE014297; AAF54551.1; -; Genomic_DNA.
DR EMBL; AY119569; AAM50223.1; -; mRNA.
DR RefSeq; NP_731505.1; NM_169361.3.
DR AlphaFoldDB; C0HK95; -.
DR PRIDE; C0HK95; -.
DR DNASU; 41291; -.
DR EnsemblMetazoa; FBtr0344444; FBpp0310816; FBgn0266451.
DR GeneID; 41291; -.
DR KEGG; dme:Dmel_CG45077; -.
DR CTD; 2197; -.
DR FlyBase; FBgn0266451; fau.
DR VEuPathDB; VectorBase:FBgn0266451; -.
DR OMA; THCSITS; -.
DR BioGRID-ORCS; 41291; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41291; -.
DR PRO; PR:C0HK95; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0266451; Expressed in insect adult head and 15 other tissues.
DR ExpressionAtlas; C0HK95; baseline.
DR Genevisible; Q9VGX3; DM.
DR GO; GO:0034059; P:response to anoxia; IMP:FlyBase.
PE 2: Evidence at transcript level;
KW Reference proteome; Stress response.
FT CHAIN 1..131
FT /note="Protein anoxia up-regulated"
FT /id="PRO_0000087203"
FT REGION 1..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 131 AA; 14371 MW; 58EF580B0F90570D CRC64;
MVYESGFTTR RTYSSRPVTT SYAVTTPRLD LCTDRPGSHR SRASSDYSYT SKSSVEKSSY
DSSNPHSYRP ERSTYTSTVE KTSRSGPGGS YNYSTERTST TGAGPGGYSY SSTTSGNLPG
GTKYRHFSYH V
