AIM34_YEAST
ID AIM34_YEAST Reviewed; 198 AA.
AC Q03673; D6VZH8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Altered inheritance of mitochondria protein 34, mitochondrial;
DE Flags: Precursor;
GN Name=AIM34; OrderedLocusNames=YMR003W; ORFNames=YM8270.05;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA Troyanskaya O.G., Caudy A.A.;
RT "Computationally driven, quantitative experiments discover genes required
RT for mitochondrial biogenesis.";
RL PLoS Genet. 5:E1000407-E1000407(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:14562095}; Single-pass membrane protein
CC {ECO:0000269|PubMed:14562095}.
CC -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC {ECO:0000269|PubMed:19300474}.
CC -!- MISCELLANEOUS: Present with 2820 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the AIM34 family. {ECO:0000305}.
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DR EMBL; Z48613; CAA88518.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09902.1; -; Genomic_DNA.
DR PIR; S53032; S53032.
DR RefSeq; NP_013716.1; NM_001182499.1.
DR AlphaFoldDB; Q03673; -.
DR SMR; Q03673; -.
DR BioGRID; 35173; 194.
DR DIP; DIP-4514N; -.
DR IntAct; Q03673; 1.
DR MINT; Q03673; -.
DR STRING; 4932.YMR003W; -.
DR PaxDb; Q03673; -.
DR PRIDE; Q03673; -.
DR EnsemblFungi; YMR003W_mRNA; YMR003W; YMR003W.
DR GeneID; 855015; -.
DR KEGG; sce:YMR003W; -.
DR SGD; S000004605; AIM34.
DR VEuPathDB; FungiDB:YMR003W; -.
DR eggNOG; ENOG502S5IP; Eukaryota.
DR HOGENOM; CLU_119188_0_0_1; -.
DR InParanoid; Q03673; -.
DR BioCyc; YEAST:G3O-32714-MON; -.
DR PRO; PR:Q03673; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q03673; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 1.10.720.30; -; 1.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF68906; SSF68906; 1.
DR PROSITE; PS50800; SAP; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..55
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 56..198
FT /note="Altered inheritance of mitochondria protein 34,
FT mitochondrial"
FT /id="PRO_0000203268"
FT TRANSMEM 172..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 69..103
FT /note="SAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00186"
SQ SEQUENCE 198 AA; 22742 MW; CBA09B4FE5BBA795 CRC64;
MSISLLGRIV SQQFSGIRAA EPGRSLYLPF TLLLKQPGAY KVSLHRYVHS TQTKSHLSFL
MNNNDITPFQ KFTVKVLKEQ CKSRGLKLSG RKSDLLQRLI THDSCSNKKS SVKINEPKKK
RILINDPIKI TKKLVSDKTF RTIEKNISSL QNTPVIETPC DVHSHLQPRD RIFLLGFFML
SCLWWNLEPQ ESKPTIDH
