ID   FAXC_MOUSE              Reviewed;         409 AA.
AC   Q3UMF9;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Failed axon connections homolog;
GN   Name=Faxc;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in axonal development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAX family. {ECO:0000305}.
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DR   EMBL; AK144924; BAE26139.1; -; mRNA.
DR   EMBL; AL772187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL772278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466538; EDL05547.1; -; Genomic_DNA.
DR   CCDS; CCDS51130.1; -.
DR   RefSeq; NP_780443.2; NM_175234.4.
DR   AlphaFoldDB; Q3UMF9; -.
DR   SMR; Q3UMF9; -.
DR   BioGRID; 217982; 1.
DR   STRING; 10090.ENSMUSP00000029908; -.
DR   iPTMnet; Q3UMF9; -.
DR   PhosphoSitePlus; Q3UMF9; -.
DR   jPOST; Q3UMF9; -.
DR   PaxDb; Q3UMF9; -.
DR   PRIDE; Q3UMF9; -.
DR   ProteomicsDB; 267573; -.
DR   Antibodypedia; 48407; 49 antibodies from 10 providers.
DR   DNASU; 76132; -.
DR   Ensembl; ENSMUST00000029908; ENSMUSP00000029908; ENSMUSG00000028246.
DR   GeneID; 76132; -.
DR   KEGG; mmu:76132; -.
DR   UCSC; uc008sdl.2; mouse.
DR   CTD; 84553; -.
DR   MGI; MGI:1923382; Faxc.
DR   VEuPathDB; HostDB:ENSMUSG00000028246; -.
DR   eggNOG; KOG4244; Eukaryota.
DR   GeneTree; ENSGT00950000182919; -.
DR   HOGENOM; CLU_044137_2_0_1; -.
DR   InParanoid; Q3UMF9; -.
DR   OMA; CTDHEQC; -.
DR   OrthoDB; 1180930at2759; -.
DR   PhylomeDB; Q3UMF9; -.
DR   TreeFam; TF314915; -.
DR   BioGRID-ORCS; 76132; 2 hits in 77 CRISPR screens.
DR   ChiTaRS; Faxc; mouse.
DR   PRO; PR:Q3UMF9; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q3UMF9; protein.
DR   Bgee; ENSMUSG00000028246; Expressed in ear vesicle and 174 other tissues.
DR   Genevisible; Q3UMF9; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026928; FAX/IsoI-like.
DR   InterPro; IPR045796; FAXC_N.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR033468; Metaxin_GST.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF19333; FAXC_N; 1.
DR   Pfam; PF17171; GST_C_6; 1.
DR   Pfam; PF17172; GST_N_4; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SFLD; SFLDG01200; SUF1.1; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..409
FT                   /note="Failed axon connections homolog"
FT                   /id="PRO_0000417443"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          372..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  46811 MW;  6F283C2D1DB9CA3F CRC64;
     MHWGVGFASS RPCVVDLSWN QSISFFGWWA GSEEPFSFYG DIIAFPLQDY GGIMAGLGSD
     PWWKKTLYLT GGALLAAAAY LLHELLVIRK QQELDSKDAI ILHQFARPNN GVPSLSPFCL
     KMETYLRMAD LPYQNYFGGK LSAQGKMPWI EYNNEKVSGT EFIIDFLEEK LGVNLNKSLG
     PHERAVSRAV TKMVEEHFYW TLAYCQWVDN LNETRKMLSL SGGGPFSNLL RWVVCHITKG
     IVKREMHGHG IGRFSEEEIY MLMEKDMRSL AGLLGDKKYI MGPKLSTLDA TVFGHLAQAM
     WTLPGTRPER LIKGELINLA MYCERIRRKF WPEWHHDDDN TIYESEESSE GSKTHTPMLD
     FSFYSRTETF EDEGAENSFS RTPDTDFTGH SLFDSDVEMD DYTDHEQCK