ID   FAXC_XENTR              Reviewed;         406 AA.
AC   F7E235;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Failed axon connections homolog;
GN   Name=faxc;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: May play a role in axonal development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAX family. {ECO:0000305}.
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DR   EMBL; AAMC01037975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01037976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01037977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01037978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01037979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01037980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F7E235; -.
DR   PaxDb; F7E235; -.
DR   PRIDE; F7E235; -.
DR   eggNOG; KOG4244; Eukaryota.
DR   HOGENOM; CLU_044137_2_0_1; -.
DR   InParanoid; F7E235; -.
DR   OMA; CTDHEQC; -.
DR   TreeFam; TF314915; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026928; FAX/IsoI-like.
DR   InterPro; IPR045796; FAXC_N.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR033468; Metaxin_GST.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF19333; FAXC_N; 1.
DR   Pfam; PF17171; GST_C_6; 1.
DR   Pfam; PF17172; GST_N_4; 1.
DR   SFLD; SFLDG01200; SUF1.1; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..406
FT                   /note="Failed axon connections homolog"
FT                   /id="PRO_0000417445"
FT   TRANSMEM        65..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          335..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          369..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..351
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  46561 MW;  66487BF82D00A37A CRC64;
     MHWGVGLVSS RSCVVDLSRN QTLSLCWCWG SEENYSFYGD IVAFPLQDYG GVMSGLGSDS
     WWKKTLYLTG GALLAAAAYL LHELLAIRKE QEVNSKDAII LHQFSRPNNG VPSLSPFCLK
     IETYLRMADL PYQNYFDGKL SPQGKMPWIE YNHTRVSGTE FIIDFLEEKL GVNLNKHLNP
     HQRAVSRAVT KMVEEHFYWT LAYCQWVENL DETQKMLNIT GPLSDLLKWI LCHLTKGIVK
     REMYGQGIGR FSEEEIYRLM EKDMRSLAGL LGDKKYLMGP KFSTLDATVF GHIANALWGT
     QGTYKEEGIA GELINLAMYC ERIRRKFWPE WHDDNDNTTY ESDDSGEDSR THTPFQDFSY
     YSRTGTFEDD GMDNSISQTP DTDFTGHSLF DSDVDMDEFT DHDQCK