FB161_ARATH
ID FB161_ARATH Reviewed; 388 AA.
AC Q9LJ74;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=F-box protein ETP2 {ECO:0000303|PubMed:19196655};
DE AltName: Full=EIN2 targeting protein 2 {ECO:0000303|PubMed:19196655};
GN Name=ETP2 {ECO:0000303|PubMed:19196655};
GN OrderedLocusNames=At3g18910 {ECO:0000312|Araport:AT3G18910};
GN ORFNames=K13E13.1 {ECO:0000312|EMBL:BAB01688.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R.F., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, INTERACTION WITH EIN2, DISRUPTION PHENOTYPE, AND INDUCTION BY
RP ETHYLENE.
RX PubMed=19196655; DOI=10.1101/gad.1765709;
RA Qiao H., Chang K.N., Yazaki J., Ecker J.R.;
RT "Interplay between ethylene, ETP1/ETP2 F-box proteins, and degradation of
RT EIN2 triggers ethylene responses in Arabidopsis.";
RL Genes Dev. 23:512-521(2009).
CC -!- FUNCTION: Negative regulator of EIN2 protein stability.
CC {ECO:0000269|PubMed:19196655}.
CC -!- SUBUNIT: Interacts with EIN2 (via C-terminus).
CC {ECO:0000269|PubMed:19196655}.
CC -!- INTERACTION:
CC Q9LJ74; Q9S814: EIN2; NbExp=2; IntAct=EBI-2437385, EBI-2437287;
CC -!- INDUCTION: Ethylene treatment has no effect on RNA, but down-regulates
CC the protein levels. {ECO:0000269|PubMed:19196655}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype, probably due to the
CC redundancy with ETP1. {ECO:0000269|PubMed:19196655}.
CC -!- MISCELLANEOUS: Double knock-down mutants of ETP1 and ETP2 show an
CC accumulation of EIN2 protein and a constitutive ethylene response.
CC {ECO:0000269|PubMed:19196655}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP000735; BAB01688.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76168.1; -; Genomic_DNA.
DR EMBL; BT012550; AAS99694.1; -; mRNA.
DR EMBL; AK175224; BAD42987.1; -; mRNA.
DR RefSeq; NP_188521.1; NM_112777.4.
DR AlphaFoldDB; Q9LJ74; -.
DR BioGRID; 6757; 1.
DR IntAct; Q9LJ74; 1.
DR STRING; 3702.AT3G18910.1; -.
DR PaxDb; Q9LJ74; -.
DR PRIDE; Q9LJ74; -.
DR ProteomicsDB; 230879; -.
DR DNASU; 821424; -.
DR EnsemblPlants; AT3G18910.1; AT3G18910.1; AT3G18910.
DR GeneID; 821424; -.
DR Gramene; AT3G18910.1; AT3G18910.1; AT3G18910.
DR KEGG; ath:AT3G18910; -.
DR Araport; AT3G18910; -.
DR TAIR; locus:2085834; AT3G18910.
DR HOGENOM; CLU_034692_0_0_1; -.
DR InParanoid; Q9LJ74; -.
DR OMA; CCERWID; -.
DR OrthoDB; 634455at2759; -.
DR PhylomeDB; Q9LJ74; -.
DR PRO; PR:Q9LJ74; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJ74; baseline and differential.
DR Genevisible; Q9LJ74; AT.
DR InterPro; IPR006527; F-box-assoc_dom_typ1.
DR InterPro; IPR017451; F-box-assoc_interact_dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR Pfam; PF00646; F-box; 1.
DR Pfam; PF07734; FBA_1; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF50965; SSF50965; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR TIGRFAMs; TIGR01640; F_box_assoc_1; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..388
FT /note="F-box protein ETP2"
FT /id="PRO_0000283431"
FT DOMAIN 2..48
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ SEQUENCE 388 AA; 44619 MW; 059A4B219DE2AF0C CRC64;
MKTIQEQLPN DLVEEILCRV PATSLRRLRS TCKAWNRLFK GDRILASKHF EKSAKQFRSL
SLRNDYRIFP ISFNLHGNSP SLELKSELID PHSKNSAAPF EISRVIHCEG LLLCSSQLDE
SRVVVWNPLT GETRWIRTGD FRQKGRSFDV GYYYQKDKRS WIKSYKLLCY YRGTKYFEIY
DFDSDSWRIL DDIIAPRGSI GYSELSVSLK GNTYWFAKGV TEERPRTISL LKFDFYTEKS
VPVLLPYQSR RLFQASSLSV VREDKLSVLL QLDQSSKTEI WVTNVIDETT KGAVSWTKVL
ALDLSPHLQI GNDGSFFLGE DKKVVMFCEK LIDENKVKDM VYIVGEDNVV TEVGFGVDEM
DGCRAVILNY VPSLVQIERA GGNRKRGH
