FB162_ARATH
ID FB162_ARATH Reviewed; 415 AA.
AC Q9LJ68; Q8LB99;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=F-box protein ETP1 {ECO:0000303|PubMed:19196655};
DE AltName: Full=EIN2 targeting protein 1 {ECO:0000303|PubMed:19196655};
GN Name=ETP1 {ECO:0000303|PubMed:19196655};
GN OrderedLocusNames=At3g18980 {ECO:0000312|Araport:AT3G18980};
GN ORFNames=K13E13.9 {ECO:0000312|EMBL:BAB01694.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, INTERACTION WITH EIN2, DISRUPTION PHENOTYPE, AND INDUCTION BY
RP ETHYLENE.
RX PubMed=19196655; DOI=10.1101/gad.1765709;
RA Qiao H., Chang K.N., Yazaki J., Ecker J.R.;
RT "Interplay between ethylene, ETP1/ETP2 F-box proteins, and degradation of
RT EIN2 triggers ethylene responses in Arabidopsis.";
RL Genes Dev. 23:512-521(2009).
CC -!- FUNCTION: Negative regulator of EIN2 protein stability.
CC {ECO:0000269|PubMed:19196655}.
CC -!- SUBUNIT: Interacts with EIN2 (via C-terminus).
CC {ECO:0000269|PubMed:19196655}.
CC -!- INTERACTION:
CC Q9LJ68; Q9S814: EIN2; NbExp=4; IntAct=EBI-1238820, EBI-2437287;
CC -!- INDUCTION: Ethylene treatment has no effect on RNA, but down-regulates
CC the protein levels. {ECO:0000269|PubMed:19196655}.
CC -!- DISRUPTION PHENOTYPE: Slight ethylene hypersensitivity.
CC {ECO:0000269|PubMed:19196655}.
CC -!- MISCELLANEOUS: Double knock-down mutants of ETP1 and ETP2 show an
CC accumulation of EIN2 protein and a constitutive ethylene response.
CC {ECO:0000269|PubMed:19196655}.
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DR EMBL; AP000735; BAB01694.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76176.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76177.1; -; Genomic_DNA.
DR EMBL; AY045839; AAK76513.1; -; mRNA.
DR EMBL; AY091375; AAM14314.1; -; mRNA.
DR EMBL; AY087337; AAM64887.1; -; mRNA.
DR RefSeq; NP_001078185.1; NM_001084716.2.
DR RefSeq; NP_566622.1; NM_112784.3.
DR AlphaFoldDB; Q9LJ68; -.
DR BioGRID; 6764; 1.
DR IntAct; Q9LJ68; 2.
DR STRING; 3702.AT3G18980.1; -.
DR PaxDb; Q9LJ68; -.
DR PRIDE; Q9LJ68; -.
DR ProteomicsDB; 230880; -.
DR EnsemblPlants; AT3G18980.1; AT3G18980.1; AT3G18980.
DR EnsemblPlants; AT3G18980.2; AT3G18980.2; AT3G18980.
DR GeneID; 821431; -.
DR Gramene; AT3G18980.1; AT3G18980.1; AT3G18980.
DR Gramene; AT3G18980.2; AT3G18980.2; AT3G18980.
DR KEGG; ath:AT3G18980; -.
DR Araport; AT3G18980; -.
DR TAIR; locus:2085839; AT3G18980.
DR HOGENOM; CLU_034692_0_0_1; -.
DR InParanoid; Q9LJ68; -.
DR OMA; TSEYRIC; -.
DR OrthoDB; 634455at2759; -.
DR PhylomeDB; Q9LJ68; -.
DR PRO; PR:Q9LJ68; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJ68; baseline and differential.
DR Genevisible; Q9LJ68; AT.
DR InterPro; IPR006527; F-box-assoc_dom_typ1.
DR InterPro; IPR017451; F-box-assoc_interact_dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR Pfam; PF00646; F-box; 1.
DR Pfam; PF07734; FBA_1; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF50965; SSF50965; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR TIGRFAMs; TIGR01640; F_box_assoc_1; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..415
FT /note="F-box protein ETP1"
FT /id="PRO_0000283432"
FT DOMAIN 1..46
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT CONFLICT 85
FT /note="E -> D (in Ref. 4; AAM64887)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="S -> N (in Ref. 4; AAM64887)"
FT /evidence="ECO:0000305"
FT CONFLICT 335
FT /note="A -> T (in Ref. 4; AAM64887)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 415 AA; 47886 MW; F5792A61198CE408 CRC64;
MTIPDLCNDL VDEILCRVPA RNLKRLRSTS KRWNRLFKDD RRFAREHMHK APKEYLPLML
TSEYRICPVS INLQGDVPSV VLKRELSLPD PDYSHQFDIG RVFHCDGLLV CNHVGKNPRY
GSKIVVWNPL TGQTRWIEAG YRWKEYEVRF VLGYCYQQDE NNSCSKKIYK ILCFYPNGQD
TEIYELNYSD RWTRTIPDGD LTPGWTLIYS EQTVSMNGNL YLFASEKSKP HLGVSLLRFD
FSTEKSSLCV TLPYQRPRYE ILSISAVRGG ENLSLLLQLD FESKTEIWVT NKIDDTTTKG
AAVSWTKVLA FDLSPDLQLF SEEVNFLLDE DKKVAVCCER WLEPQEHHRY QCRREYKITD
KIYILGEDNK VDEVGSGEGE ATDSLEGISQ VILNYAPSLV QIEQAGGGKT KRGDD
