FB211_ARATH
ID FB211_ARATH Reviewed; 491 AA.
AC Q2V3N5; A4VCN0; Q9LYT6;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=F-box protein At3g59000;
GN OrderedLocusNames=At3g59000; ORFNames=F17J16.50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Bautista-Mercan V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C.,
RA Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH ASK4.
RX PubMed=12169662; DOI=10.1073/pnas.162339999;
RA Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.;
RT "The F-box subunit of the SCF E3 complex is encoded by a diverse
RT superfamily of genes in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with ASK4. {ECO:0000250,
CC ECO:0000269|PubMed:12169662}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2V3N5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2V3N5-2; Sequence=VSP_024319;
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB86928.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL163527; CAB86928.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE79858.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79859.1; -; Genomic_DNA.
DR EMBL; BT030471; ABP88125.1; -; mRNA.
DR PIR; T47782; T47782.
DR RefSeq; NP_001030887.1; NM_001035810.1. [Q2V3N5-2]
DR RefSeq; NP_191459.2; NM_115762.3. [Q2V3N5-1]
DR AlphaFoldDB; Q2V3N5; -.
DR BioGRID; 10384; 2.
DR IntAct; Q2V3N5; 1.
DR STRING; 3702.AT3G59000.1; -.
DR PaxDb; Q2V3N5; -.
DR PRIDE; Q2V3N5; -.
DR EnsemblPlants; AT3G59000.1; AT3G59000.1; AT3G59000. [Q2V3N5-1]
DR EnsemblPlants; AT3G59000.2; AT3G59000.2; AT3G59000. [Q2V3N5-2]
DR GeneID; 825069; -.
DR Gramene; AT3G59000.1; AT3G59000.1; AT3G59000. [Q2V3N5-1]
DR Gramene; AT3G59000.2; AT3G59000.2; AT3G59000. [Q2V3N5-2]
DR KEGG; ath:AT3G59000; -.
DR Araport; AT3G59000; -.
DR TAIR; locus:2077695; AT3G59000.
DR eggNOG; ENOG502RYTW; Eukaryota.
DR HOGENOM; CLU_010721_7_4_1; -.
DR InParanoid; Q2V3N5; -.
DR OMA; HMADIEW; -.
DR OrthoDB; 816963at2759; -.
DR PhylomeDB; Q2V3N5; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q2V3N5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q2V3N5; baseline and differential.
DR Genevisible; Q2V3N5; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR006566; FBD.
DR InterPro; IPR013101; Leu-rich_rpt_2.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF07723; LRR_2; 1.
DR SMART; SM00579; FBD; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..491
FT /note="F-box protein At3g59000"
FT /id="PRO_0000283481"
FT DOMAIN 1..49
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT VAR_SEQ 122..267
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_024319"
SQ SEQUENCE 491 AA; 55726 MW; 2A3FDFE522F8E8ED CRC64;
MDRVGSLPDE LLSHILSFLT TKEAALTSLL SKRWRYLIAF VPNLAFDDIV FLHPEEGKPE
RDEIRQSFMD FVDRVLALQA ESPIKKFSLK CRIGVDSDRV DGWISNVLNR GVSELDLLII
LGMTMEDSYR LSPKGFASKT LVKLEIGCGI DISWVAGSIF LPMLKTLVLD SVWFYVDKFE
TLLLALPALE ELVLVDVNWL DSDVTISNAS LKTLTIDSDG HLGTFSFDTP SLVYFCYSDY
AAEDYPVVKM ENLREARIFL LVTDNEIERV RLPINDGLED AMDNVVLRFG HVGKLMNGIR
NVEYLELSAD TLEVLSLCCE SMPVFKNLKS LAIKSTEGRG WQAMPVLLRN CPHLEFLLIE
GLLHHVTDKC GDACDCVPRE DKGRSLTSCP VNMLEIHGFR GTKKEMQMIK HFLDYFPSLK
EMDIYADEDG PTNLEAPGMF EQITQLFTLY DEFYTCDVQF MVRGSLYKKL TAQCCVFKEE
NLPHRLVRTL G
