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AIM36_YEAST
ID   AIM36_YEAST             Reviewed;         255 AA.
AC   Q03798; D6VZX8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Altered inheritance of mitochondria protein 36, mitochondrial;
DE   AltName: Full=Found in mitochondrial proteome protein 39;
DE   Flags: Precursor;
GN   Name=AIM36; Synonyms=FMP39; OrderedLocusNames=YMR157C; ORFNames=YM8520.06C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA   Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA   Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA   Troyanskaya O.G., Caudy A.A.;
RT   "Computationally driven, quantitative experiments discover genes required
RT   for mitochondrial biogenesis.";
RL   PLoS Genet. 5:E1000407-E1000407(2009).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000269|PubMed:14562095}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:14562095}.
CC   -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC       {ECO:0000269|PubMed:19300474}.
CC   -!- MISCELLANEOUS: Present with 1710 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the AIM36 family. {ECO:0000305}.
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DR   EMBL; Z49705; CAA89793.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA10052.1; -; Genomic_DNA.
DR   PIR; S54515; S54515.
DR   RefSeq; NP_013878.1; NM_001182660.1.
DR   AlphaFoldDB; Q03798; -.
DR   SMR; Q03798; -.
DR   BioGRID; 35332; 104.
DR   DIP; DIP-4466N; -.
DR   STRING; 4932.YMR157C; -.
DR   iPTMnet; Q03798; -.
DR   MaxQB; Q03798; -.
DR   PaxDb; Q03798; -.
DR   PRIDE; Q03798; -.
DR   EnsemblFungi; YMR157C_mRNA; YMR157C; YMR157C.
DR   GeneID; 855189; -.
DR   KEGG; sce:YMR157C; -.
DR   SGD; S000004766; AIM36.
DR   VEuPathDB; FungiDB:YMR157C; -.
DR   eggNOG; ENOG502S2G9; Eukaryota.
DR   HOGENOM; CLU_090420_0_0_1; -.
DR   InParanoid; Q03798; -.
DR   OMA; RVAIFPQ; -.
DR   BioCyc; YEAST:G3O-32847-MON; -.
DR   PRO; PR:Q03798; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; Q03798; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT         1..40
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           41..255
FT                   /note="Altered inheritance of mitochondria protein 36,
FT                   mitochondrial"
FT                   /id="PRO_0000203312"
FT   TRANSMEM        64..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   255 AA;  29077 MW;  E72D9CE2421A6ABD CRC64;
     MLRPLRKSVL ASCRHCFKVC GGLPQKQLPL FSPLLLRARY SSTDSSTKRS NKSDKIDAPG
     FKKIFLVAII GTVIFVKTVQ SLDKNKPKTT LSEEEFENVV KGLKRRVAIF PQGEVDIKFS
     LSPSIEETRK VLQKSQGDDI NELQFVDPVK VIDYYRTLRD DRYEALLNEY YKKYGCDTYA
     YNLPTGMLVM LLGRYFKENF KTGDKLVVVN FPHSIADATR FENEVSIVSK IFVPRKLSGS
     DVCKYYETVG KADII
 
 
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