ID   FB31B_XENLA             Reviewed;         523 AA.
AC   A2BD94;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=F-box only protein 31-B;
GN   Name=fbxo31-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase
CC       complex that plays a central role in G1 arrest following DNA damage.
CC       Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its
CC       ubiquitination and degradation by the proteasome, resulting in G1
CC       arrest (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FBXO31 family. {ECO:0000305}.
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DR   EMBL; BC130117; AAI30118.1; -; mRNA.
DR   RefSeq; NP_001091269.1; NM_001097800.1.
DR   AlphaFoldDB; A2BD94; -.
DR   SMR; A2BD94; -.
DR   PRIDE; A2BD94; -.
DR   DNASU; 100037076; -.
DR   GeneID; 100037076; -.
DR   KEGG; xla:100037076; -.
DR   CTD; 100037076; -.
DR   Xenbase; XB-GENE-6255522; fbxo31.L.
DR   OrthoDB; 484321at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 100037076; Expressed in heart and 19 other tissues.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0030332; F:cyclin binding; IEA:InterPro.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0031571; P:mitotic G1 DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR026941; FBXO31.
DR   InterPro; IPR045048; FBXO31/39.
DR   PANTHER; PTHR10706; PTHR10706; 1.
DR   PANTHER; PTHR10706:SF130; PTHR10706:SF130; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; DNA damage; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..523
FT                   /note="F-box only protein 31-B"
FT                   /id="PRO_0000378165"
FT   DOMAIN          59..105
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REGION          372..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..422
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  59954 MW;  AD2C030667E04B79 CRC64;
     MAVCARLCGV GQSGGCRRRR QRKGAGNDPE LEDEEEEDEV RIEAEVLVEG QAAVAPLRPR
     SLLQLPPEIL VEIFSSLPGT ELPSLAQVCR KFRQILTTDT IWKRRCKQEY GVCENLRKLE
     VTGVSCHDVY VKLLHQYRHI LGLWQPDIGP YGGLLNVVVD GLFIIGWMYL PPHDPHVDEG
     MRLKPVFRIH LMERNNATVE CMYGHKGPHN GQIQIVKKDE FSTKCLQTDY HRMSGGRQEE
     FRTWLREDLG RTLEDIFHEH MQELILMKFI YICQYDKCLT YRRIYHPPNR PDDLLNPGFF
     KGTYGSHGLE IVMFSFHGTI AKATKITGDP NVPAGQQTLE VDLTRPVQLP DVEHLRNFDE
     ISRLILDVQS QIQREQRQTG NEEDDGKGAG PDRAEHSQQP APVHRPAKED VNGVDNADDR
     EQKPPNVQSF VLPAGVMARN EEYPRSCKMC FYGTGLIAGH GFSSPERTPG LFILFDEDRF
     GFIWLELKSF SLYSRMRDRF QHSEAPSLEA FDEMLQHMQS WTT