AIM39_YEAST
ID AIM39_YEAST Reviewed; 395 AA.
AC Q08223; D6W214; Q05667;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Altered inheritance of mitochondria protein 39, mitochondrial;
DE Flags: Precursor;
GN Name=AIM39; OrderedLocusNames=YOL053W; ORFNames=O1269;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8789261;
RX DOI=10.1002/(sici)1097-0061(199601)12:1<67::aid-yea884>3.0.co;2-f;
RA Mannhaupt G., Vetter I., Schwarzlose C., Mitzel S., Feldmann H.;
RT "Analysis of a 26 kb region on the left arm of yeast chromosome XV.";
RL Yeast 12:67-76(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA Troyanskaya O.G., Caudy A.A.;
RT "Computationally driven, quantitative experiments discover genes required
RT for mitochondrial biogenesis.";
RL PLoS Genet. 5:E1000407-E1000407(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC {ECO:0000269|PubMed:19300474}.
CC -!- SIMILARITY: Belongs to the AIM39 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA62535.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X91067; CAA62535.1; ALT_FRAME; Genomic_DNA.
DR EMBL; Z74795; CAA99060.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10730.1; -; Genomic_DNA.
DR PIR; S66738; S66738.
DR RefSeq; NP_014588.1; NM_001183308.1.
DR AlphaFoldDB; Q08223; -.
DR SMR; Q08223; -.
DR BioGRID; 34350; 150.
DR MaxQB; Q08223; -.
DR PaxDb; Q08223; -.
DR PRIDE; Q08223; -.
DR EnsemblFungi; YOL053W_mRNA; YOL053W; YOL053W.
DR GeneID; 854103; -.
DR KEGG; sce:YOL053W; -.
DR SGD; S000005414; AIM39.
DR VEuPathDB; FungiDB:YOL053W; -.
DR eggNOG; ENOG502QT12; Eukaryota.
DR HOGENOM; CLU_058942_0_0_1; -.
DR InParanoid; Q08223; -.
DR OMA; WCEDQDP; -.
DR BioCyc; YEAST:G3O-33464-MON; -.
DR PRO; PR:Q08223; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08223; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..395
FT /note="Altered inheritance of mitochondria protein 39,
FT mitochondrial"
FT /id="PRO_0000235924"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 395 AA; 45851 MW; 45076DB8E860D828 CRC64;
MWGLCKKHFP SNKIQVQERN KALKPKKSGS EHKTKQLFPV FNCKKKEKGV MIRFAILRNA
NTSLLSARSI CLFTQAPTYC HVRLNTLNKS ITTKRNSLTE SKRHVHDGKH FFTTPHQQQQ
TKLGEIEEGH SPNIKGEDLR SIGQAITHQR NKRRKQIWSA IFGGIFGVIL GYSLIYRVIY
LKEQSFLPLF PSSKIRKLST RDLKKVDVNQ VQKLSKLRVL EILSGHDMIK EQYGVPLLDK
DGNSPTLNEF SMWCEDQDPC VTGIVMEPDD KRDSSHTWYR IPFVCKWRIT HRPISIRGTI
DDLLNRIGLE TADLFEIISP ERVYGSFKYE YPLQGDSHAL HLWFHGEIEL DDDSLIVYNG
KYHVDVKLQE IDLFRREKNG QLIQYVLYKN EAGDK
