ID   3MGH_LACAC              Reviewed;         210 AA.
AC   Q5FMR0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Putative 3-methyladenine DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00527};
DE            EC=3.2.2.- {ECO:0000255|HAMAP-Rule:MF_00527};
GN   OrderedLocusNames=LBA0113;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00527}.
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DR   EMBL; CP000033; AAV42014.1; -; Genomic_DNA.
DR   RefSeq; WP_011254043.1; NC_006814.3.
DR   RefSeq; YP_193045.1; NC_006814.3.
DR   AlphaFoldDB; Q5FMR0; -.
DR   SMR; Q5FMR0; -.
DR   STRING; 272621.LBA0113; -.
DR   PRIDE; Q5FMR0; -.
DR   EnsemblBacteria; AAV42014; AAV42014; LBA0113.
DR   GeneID; 56941726; -.
DR   KEGG; lac:LBA0113; -.
DR   PATRIC; fig|272621.13.peg.108; -.
DR   eggNOG; COG2094; Bacteria.
DR   HOGENOM; CLU_060471_2_0_9; -.
DR   OMA; VEAYHHT; -.
DR   BioCyc; LACI272621:G1G49-112-MON; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   CDD; cd00540; AAG; 1.
DR   Gene3D; 3.10.300.10; -; 1.
DR   HAMAP; MF_00527; 3MGH; 1.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR003180; MPG.
DR   InterPro; IPR036995; MPG_sf.
DR   PANTHER; PTHR10429; PTHR10429; 1.
DR   Pfam; PF02245; Pur_DNA_glyco; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   TIGRFAMs; TIGR00567; 3mg; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Hydrolase; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Putative 3-methyladenine DNA glycosylase"
FT                   /id="PRO_0000265026"
SQ   SEQUENCE   210 AA;  23844 MW;  76871B8EC3D46B5C CRC64;
     MNYAEYFTNR STDEITRDLI GRPLTFNDGQ EKLGGYIVEA EAYMGKLDRA AHSYGGHRSP
     ANEGLYRTGG TIYIYAQRQY FFFDVACQEE NEPQGVLVRA IDPAWGIDSM IKNRNGKSGV
     LITNGPAKMM QAFGIHDKNW NLHFLSDSPF TIDLADNHKR IAQEIIADKR VGINQSDPIW
     ANKKLRYYVA GNPYVSDMKK RDYASNNGWT