FBK49_ARATH
ID FBK49_ARATH Reviewed; 390 AA.
AC Q9SR08;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=F-box/kelch-repeat protein At3g04660;
GN OrderedLocusNames=At3g04660; ORFNames=F7O18.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2; ASK11 AND ASK13.
RX PubMed=12169662; DOI=10.1073/pnas.162339999;
RA Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.;
RT "The F-box subunit of the SCF E3 complex is encoded by a diverse
RT superfamily of genes in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with SKP1A/ASK1, SKP1B/ASK2, ASK11 and ASK13.
CC {ECO:0000250, ECO:0000269|PubMed:12169662}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC011437; AAF04896.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74115.1; -; Genomic_DNA.
DR RefSeq; NP_187117.1; NM_111338.3.
DR AlphaFoldDB; Q9SR08; -.
DR SMR; Q9SR08; -.
DR BioGRID; 4959; 2.
DR STRING; 3702.AT3G04660.1; -.
DR iPTMnet; Q9SR08; -.
DR PaxDb; Q9SR08; -.
DR PRIDE; Q9SR08; -.
DR EnsemblPlants; AT3G04660.1; AT3G04660.1; AT3G04660.
DR GeneID; 819624; -.
DR Gramene; AT3G04660.1; AT3G04660.1; AT3G04660.
DR KEGG; ath:AT3G04660; -.
DR Araport; AT3G04660; -.
DR TAIR; locus:2084923; AT3G04660.
DR HOGENOM; CLU_027176_8_1_1; -.
DR InParanoid; Q9SR08; -.
DR OMA; HICGANQ; -.
DR OrthoDB; 731539at2759; -.
DR PhylomeDB; Q9SR08; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9SR08; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SR08; baseline and differential.
DR Genevisible; Q9SR08; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR InterPro; IPR013187; F-box-assoc_dom_typ3.
DR InterPro; IPR017451; F-box-assoc_interact_dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR Pfam; PF00646; F-box; 1.
DR Pfam; PF08268; FBA_3; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR TIGRFAMs; TIGR01640; F_box_assoc_1; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..390
FT /note="F-box/kelch-repeat protein At3g04660"
FT /id="PRO_0000283209"
FT DOMAIN 18..67
FT /note="F-box"
FT REPEAT 115..161
FT /note="Kelch 1"
FT REPEAT 272..323
FT /note="Kelch 2"
SQ SEQUENCE 390 AA; 44932 MW; 7A06EAA11FC97AC9 CRC64;
MKKRGRKSKK PEEKRAEYDP SSILPLELKI EILMKSPPKS IAKLGFVSNH WSSIIRGQVF
TDLYMRRSLA HPRLLFSVYR PNMQMQFFHS CSQEDPSSDH RSVSYTLNSD LRYSFSPPIG
GLIFGQNNTK AMIGNPSTGQ FVPLPRIKTQ RKHIFSIFGY DPVNDLYKVL CMTVRTLRGP
HYFRWEDPMW EEPMTEEHQV FTLGPKQKWR MLECKYLHRH HSGSQGICRD GVMYYLASFN
DKRSLMSFDL SSEEFNVTKL PEDYILQQFG NMVDHSGKIA IVSQAYSGPM DLWVLEDVSK
EEWSKVAAIV PSITDIVGND QRVIFRGILS TGEIILSLLP TPKPPFFFLC YDPKEKTARK
VVIQGIGEDY AAINVFFDHV ESHMVLSKLT
