FBK77_ARATH
ID FBK77_ARATH Reviewed; 411 AA.
AC Q9M310;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=F-box/kelch-repeat protein At3g61590;
GN OrderedLocusNames=At3g61590; ORFNames=F2A19.190;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2; ASK3; ASK9; ASK11; ASK12; ASK13;
RP ASK14; ASK16 AND ASK18.
RX PubMed=14749489; DOI=10.1093/pcp/pch009;
RA Takahashi N., Kuroda H., Kuromori T., Hirayama T., Seki M., Shinozaki K.,
RA Shimada H., Matsui M.;
RT "Expression and interaction analysis of Arabidopsis Skp1-related genes.";
RL Plant Cell Physiol. 45:83-91(2004).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with SKP1A/ASK1, SKP1B/ASK2, ASK3, ASK9, ASK11,
CC ASK12, ASK13, ASK14, ASK16 and ASK18. {ECO:0000250,
CC ECO:0000269|PubMed:14749489}.
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000250}.
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DR EMBL; AL132962; CAB71089.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80227.1; -; Genomic_DNA.
DR EMBL; AF386994; AAK62439.1; -; mRNA.
DR EMBL; BT000054; AAN15373.1; -; mRNA.
DR PIR; T47951; T47951.
DR RefSeq; NP_191718.1; NM_116024.3.
DR AlphaFoldDB; Q9M310; -.
DR SMR; Q9M310; -.
DR BioGRID; 10646; 11.
DR IntAct; Q9M310; 14.
DR STRING; 3702.AT3G61590.1; -.
DR PaxDb; Q9M310; -.
DR PRIDE; Q9M310; -.
DR ProteomicsDB; 230906; -.
DR EnsemblPlants; AT3G61590.1; AT3G61590.1; AT3G61590.
DR GeneID; 825332; -.
DR Gramene; AT3G61590.1; AT3G61590.1; AT3G61590.
DR KEGG; ath:AT3G61590; -.
DR Araport; AT3G61590; -.
DR TAIR; locus:2082797; AT3G61590.
DR eggNOG; ENOG502QUHY; Eukaryota.
DR HOGENOM; CLU_038778_3_0_1; -.
DR InParanoid; Q9M310; -.
DR PhylomeDB; Q9M310; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9M310; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M310; baseline and differential.
DR Genevisible; Q9M310; AT.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:TAIR.
DR GO; GO:0035195; P:miRNA-mediated gene silencing; IMP:TAIR.
DR GO; GO:0099402; P:plant organ development; IMP:TAIR.
DR Gene3D; 2.120.10.80; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR045048; FBXO31/39.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR PANTHER; PTHR10706; PTHR10706; 1.
DR Pfam; PF00646; F-box; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..411
FT /note="F-box/kelch-repeat protein At3g61590"
FT /id="PRO_0000283237"
FT DOMAIN 37..83
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 81..135
FT /note="Kelch 1"
FT REPEAT 137..178
FT /note="Kelch 2"
FT REPEAT 196..246
FT /note="Kelch 3"
FT REPEAT 251..299
FT /note="Kelch 4"
FT REPEAT 302..350
FT /note="Kelch 5"
FT REPEAT 352..401
FT /note="Kelch 6"
SQ SEQUENCE 411 AA; 46972 MW; 0F2FEF44CA68ED00 CRC64;
MEAETSWTNY PYSYITYVPE AESYREQSDD EAKVETFSMD SLLPDDLLER ILSFLPIASI
FRAGTVCKRW NEIVSSRRFL CNFSNNSVSQ RPWYFMFTTT DDPSGYAYDP IIRKWYSFDL
PCIETSNWFV ASSCGLVCFM DNDCRNKIYV SNPITKQWRT LIEPPGHKST DYTAMSTSVN
RANQAVNRAN RSYSVSIVKS KQVPGNFFQW DLSIHLYSSE TMTWTTLVND VLSGWRGGNE
SVICNNVLYF MIYSTGGSDH RHGLIASNLS SIGSPSSGIL MRSFIPMPCS LTCGRLMNLR
ERLVIVGGIG KHDRPEVIKG IGIWVLKGKE WVEMAKMPQR FFQGFGEFDE VFASSGTDDL
VYIQSYGSPA LLTFDMNLKY WRWSQKCPVT KKFPLQLFTG FCFEPRLEIA P
