FBK95_ARATH
ID FBK95_ARATH Reviewed; 370 AA.
AC Q9SVJ9;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=F-box/kelch-repeat protein At4g38940;
GN OrderedLocusNames=At4g38940; ORFNames=F19H22.40;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2; ASK11; ASK13 AND ASK18.
RX PubMed=12169662; DOI=10.1073/pnas.162339999;
RA Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.;
RT "The F-box subunit of the SCF E3 complex is encoded by a diverse
RT superfamily of genes in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with SKP1A/ASK1, SKP1B/ASK2, ASK11, ASK13 and
CC ASK18. {ECO:0000250, ECO:0000269|PubMed:12169662}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000250}.
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DR EMBL; AL035679; CAB38814.1; -; Genomic_DNA.
DR EMBL; AL161594; CAB80557.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86996.1; -; Genomic_DNA.
DR EMBL; AY087974; AAM65521.1; -; mRNA.
DR EMBL; AK175314; BAD43077.1; -; mRNA.
DR EMBL; AK175628; BAD43391.1; -; mRNA.
DR PIR; T06054; T06054.
DR RefSeq; NP_195605.1; NM_120054.3.
DR AlphaFoldDB; Q9SVJ9; -.
DR SMR; Q9SVJ9; -.
DR BioGRID; 15329; 3.
DR IntAct; Q9SVJ9; 5.
DR STRING; 3702.AT4G38940.1; -.
DR PaxDb; Q9SVJ9; -.
DR PRIDE; Q9SVJ9; -.
DR ProteomicsDB; 230690; -.
DR EnsemblPlants; AT4G38940.1; AT4G38940.1; AT4G38940.
DR GeneID; 830049; -.
DR Gramene; AT4G38940.1; AT4G38940.1; AT4G38940.
DR KEGG; ath:AT4G38940; -.
DR Araport; AT4G38940; -.
DR TAIR; locus:2120262; AT4G38940.
DR eggNOG; KOG1072; Eukaryota.
DR HOGENOM; CLU_032521_1_2_1; -.
DR InParanoid; Q9SVJ9; -.
DR OMA; KIYMRTY; -.
DR OrthoDB; 726064at2759; -.
DR PhylomeDB; Q9SVJ9; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9SVJ9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SVJ9; baseline and differential.
DR Genevisible; Q9SVJ9; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.120.10.80; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR Pfam; PF00646; F-box; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..370
FT /note="F-box/kelch-repeat protein At4g38940"
FT /id="PRO_0000283253"
FT DOMAIN 18..64
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 131..177
FT /note="Kelch 1"
FT REPEAT 178..230
FT /note="Kelch 2"
FT REPEAT 263..315
FT /note="Kelch 3"
SQ SEQUENCE 370 AA; 42073 MW; 61F2A86864BB7BD5 CRC64;
MSSPIIIRAP KKQPPEPPCL ISLLPEEIVV DIVARVPRCY YPTLSQVSRR FRSLVASPEI
YKRRSFFGCT EQCLYIAISK DQTSDIHWFT LCRKPNGQQF SGTTASDHRL VHIPTLPPMP
MHGSYVGIGS NIFVMGGFCN WKITSSVSLI DCRTHTAQTL PNMPKAVAFP VTELIDRKIY
VIGGSDTLSP MKSPSRIMMV YDTDTEMWQL RARPDWEAGK KWFSSVVIGG KIYMRTYHNS
FVCDPNDTSC DRDEVLHSKE WWSACVIDDV LYYYDVRENC LRAYDPKQRA WGVVKGFEGL
LPVACKWSKT VSYTGGKLVL FLQKTEKTEI WCAEIAVERR EGGEIWGKVE WCNVVLSGNF
HIMDCVAVVL
