ID   FBL11_ARATH             Reviewed;         940 AA.
AC   Q8S8F2; F4IMW4; Q0WWD2;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=BTB/POZ domain-containing protein FBL11;
GN   Name=FBL11; OrderedLocusNames=At2g36370; ORFNames=F2H17.2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-940.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11077244; DOI=10.1016/s1360-1385(00)01769-6;
RA   Xiao W., Jang J.-C.;
RT   "F-box proteins in Arabidopsis.";
RL   Trends Plant Sci. 5:454-457(2000).
RN   [5]
RP   DOMAIN BTB.
RX   PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA   Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA   Vierstra R.D.;
RT   "Cullins 3a and 3b assemble with members of the broad
RT   complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT   ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL   J. Biol. Chem. 280:18810-18821(2005).
CC   -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC       of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC   -!- CAUTION: Was originally thought to contain a F-box domain.
CC       {ECO:0000305|PubMed:11077244}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM15321.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC006921; AAM15321.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; AEC09245.2; -; Genomic_DNA.
DR   EMBL; AK226422; BAE98566.1; -; mRNA.
DR   RefSeq; NP_565845.3; NM_129194.4.
DR   AlphaFoldDB; Q8S8F2; -.
DR   STRING; 3702.AT2G36370.1; -.
DR   iPTMnet; Q8S8F2; -.
DR   PaxDb; Q8S8F2; -.
DR   PRIDE; Q8S8F2; -.
DR   ProteomicsDB; 222496; -.
DR   EnsemblPlants; AT2G36370.1; AT2G36370.1; AT2G36370.
DR   GeneID; 818210; -.
DR   Gramene; AT2G36370.1; AT2G36370.1; AT2G36370.
DR   KEGG; ath:AT2G36370; -.
DR   Araport; AT2G36370; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_018220_0_0_1; -.
DR   InParanoid; Q8S8F2; -.
DR   OMA; NIKGCAL; -.
DR   OrthoDB; 156435at2759; -.
DR   PhylomeDB; Q8S8F2; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q8S8F2; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8S8F2; baseline and differential.
DR   Genevisible; Q8S8F2; AT.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00367; LRR_CC; 5.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..940
FT                   /note="BTB/POZ domain-containing protein FBL11"
FT                   /id="PRO_0000272268"
FT   DOMAIN          41..109
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          155..258
FT                   /note="BACK"
SQ   SEQUENCE   940 AA;  104873 MW;  085A7A1AAEA4AC08 CRC64;
     MALSSLVEFV ILVVKNPCYQ QDDASSSIQE ISISASEIAS WDMSEILSYG SVKVRAHRTR
     LIQESSYFHG LLSGSFSESG LDHISVEWNL ESFLNLLMCL YGYDIEITSS SFLPLFESAL
     YFGVEKLLSI CKNWLSVLAS SNDNALPKVE LSDLIQIWSF GLEHAGEFVP DLCVAYLAKN
     FMLVKSDKYF GNVPYELLMW CVKHPHLTVH SEMDLVDGLL IWLDAGGRLS DLPESSQDNT
     INLMEQVRFS LLPLWFIAGR SKSHGFSKFA DQSIELVTKL MKMPSTCLVD SLTDGPPTDV
     RVRLTEYSEI LDLSGCPQLN EASLLLSILP NSYFANLRWR KSLESFLKNP DDDERHQEQI
     SHRTLPILSF ESVKEIDISK CQRLDYKVVI KCFSKSFPSL RKLRAAYLLN IKVSTLLELL
     LNFRELTEVD LTVDVSPIIP VQASVFYSGQ GHCLLSSITR LTLEGRSDIC DMELRSISRV
     CESLCYLNIK GCALLSDACI ASVIQRCKKL CSLIVCYTSF SENSILALCA TISMTNEHMD
     INSVASNLQT LHMSKCEGIS ETSLLNLITH SQKMKSLCLR DTKVSDSVLC EFPGSTLEAL
     DISNTTISWM ALARVISRNP NLKTLKARGC KNLLQLEVDG RTDNFSPLVS GQEVFKCLSK
     GSGLEELEIG WGFSYFSFES LRPAASFLRV ISVGLGASLG EDVLKLLPST CPLLESIVLH
     FQEISDSALT SVLTSLKHLQ ELALSYCFGE ISLQSFKFSM PNLRKLRLER VTRWMTNDDL
     LVLTQSCPNL TELSLVGCLH LTSDCQPIIS AGWPGMISLH LEECGSITEN GVASLYGCIA
     LEDLFLRHNG SGIQKSFLLD ATLKFPMLRL VSLDMCDAKE GGFDVPEEKE EGRSLSIVKI
     SRCKSDRCSL GRRAAPMHRE TLVMLWNGQT LTKTLLKQRL