FBL4_ARATH
ID FBL4_ARATH Reviewed; 610 AA.
AC Q9C5D2; O23399; Q8LGK0;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=F-box/LRR-repeat protein 4;
DE Short=AtFBL4;
GN Name=FBL4; OrderedLocusNames=At4g15475; ORFNames=dl3775w, FCAALL.58;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11077244; DOI=10.1016/s1360-1385(00)01769-6;
RA Xiao W., Jang J.-C.;
RT "F-box proteins in Arabidopsis.";
RL Trends Plant Sci. 5:454-457(2000).
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB10325.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g15470 has been split into 2 genes: At4g15470 and At4g15475.; Evidence={ECO:0000305};
CC Sequence=CAB78589.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g15470 has been split into 2 genes: At4g15470 and At4g15475.; Evidence={ECO:0000305};
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DR EMBL; Z97339; CAB10325.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161541; CAB78589.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83608.1; -; Genomic_DNA.
DR EMBL; AF360328; AAK26038.1; -; mRNA.
DR EMBL; AF361808; AAK32821.1; -; mRNA.
DR EMBL; AY056338; AAL07187.1; -; mRNA.
DR EMBL; AY084229; AAM60829.1; -; mRNA.
DR RefSeq; NP_567467.1; NM_117637.5.
DR AlphaFoldDB; Q9C5D2; -.
DR SMR; Q9C5D2; -.
DR STRING; 3702.AT4G15475.1; -.
DR PaxDb; Q9C5D2; -.
DR PRIDE; Q9C5D2; -.
DR ProteomicsDB; 222575; -.
DR EnsemblPlants; AT4G15475.1; AT4G15475.1; AT4G15475.
DR GeneID; 827219; -.
DR Gramene; AT4G15475.1; AT4G15475.1; AT4G15475.
DR KEGG; ath:AT4G15475; -.
DR Araport; AT4G15475; -.
DR TAIR; locus:505006471; AT4G15475.
DR eggNOG; KOG1947; Eukaryota.
DR HOGENOM; CLU_016072_3_0_1; -.
DR InParanoid; Q9C5D2; -.
DR OMA; RIRATSC; -.
DR OrthoDB; 1282076at2759; -.
DR PhylomeDB; Q9C5D2; -.
DR PRO; PR:Q9C5D2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9C5D2; baseline and differential.
DR Genevisible; Q9C5D2; AT.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0006289; P:nucleotide-excision repair; IMP:TAIR.
DR GO; GO:0010225; P:response to UV-C; IMP:TAIR.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR041567; COI1_F-box.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF18511; F-box_5; 1.
DR Pfam; PF13516; LRR_6; 6.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00367; LRR_CC; 17.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..610
FT /note="F-box/LRR-repeat protein 4"
FT /id="PRO_0000365172"
FT DOMAIN 5..52
FT /note="F-box"
FT REPEAT 53..79
FT /note="LRR 1"
FT REPEAT 124..149
FT /note="LRR 2"
FT REPEAT 150..175
FT /note="LRR 3"
FT REPEAT 178..200
FT /note="LRR 4"
FT REPEAT 201..227
FT /note="LRR 5"
FT REPEAT 228..253
FT /note="LRR 6"
FT REPEAT 256..277
FT /note="LRR 7"
FT REPEAT 278..303
FT /note="LRR 8"
FT REPEAT 304..329
FT /note="LRR 9"
FT REPEAT 330..355
FT /note="LRR 10"
FT REPEAT 356..381
FT /note="LRR 11"
FT REPEAT 382..407
FT /note="LRR 12"
FT REPEAT 408..433
FT /note="LRR 13"
FT REPEAT 434..459
FT /note="LRR 14"
FT REPEAT 460..484
FT /note="LRR 15"
FT REPEAT 485..510
FT /note="LRR 16"
FT REPEAT 511..536
FT /note="LRR 17"
FT REPEAT 537..562
FT /note="LRR 18"
FT REPEAT 563..588
FT /note="LRR 19"
FT REGION 88..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 71
FT /note="Y -> H (in Ref. 5; AAM60829)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="H -> Q (in Ref. 5; AAM60829)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="N -> D (in Ref. 5; AAM60829)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="V -> A (in Ref. 5; AAM60829)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="H -> N (in Ref. 5; AAM60829)"
FT /evidence="ECO:0000305"
FT CONFLICT 463
FT /note="V -> I (in Ref. 5; AAM60829)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 610 AA; 66422 MW; 2A165F930CBB69CA CRC64;
MRGHDRINNC LPEELILEIF RRLESKPNRD ACSLVCKRWL SLERFSRTTL RIGASFSPDD
FISLLSRRFL YITSIHVDER ISVSLPSLSP SPKRKRGRDS SSPSSSKRKK LTDKTHSGAE
NVESSSLTDT GLTALANGFP RIENLSLIWC PNVSSVGLCS LAQKCTSLKS LDLQGCYVGD
QGLAAVGKFC KQLEELNLRF CEGLTDVGVI DLVVGCSKSL KSIGVAASAK ITDLSLEAVG
SHCKLLEVLY LDSEYIHDKG LIAVAQGCHR LKNLKLQCVS VTDVAFAAVG ELCTSLERLA
LYSFQHFTDK GMRAIGKGSK KLKDLTLSDC YFVSCKGLEA IAHGCKELER VEINGCHNIG
TRGIEAIGKS CPRLKELALL YCQRIGNSAL QEIGKGCKSL EILHLVDCSG IGDIAMCSIA
KGCRNLKKLH IRRCYEIGNK GIISIGKHCK SLTELSLRFC DKVGNKALIA IGKGCSLQQL
NVSGCNQISD AGITAIARGC PQLTHLDISV LQNIGDMPLA ELGEGCPMLK DLVLSHCHHI
TDNGLNHLVQ KCKLLETCHM VYCPGITSAG VATVVSSCPH IKKVLIEKWK VTERTTRRAG
SVISYLCMDL
