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FBN1_PIG
ID   FBN1_PIG                Reviewed;        2871 AA.
AC   Q9TV36;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Fibrillin-1 {ECO:0000250|UniProtKB:P35555};
DE   Contains:
DE     RecName: Full=Asprosin {ECO:0000250|UniProtKB:P35555};
DE   Flags: Precursor;
GN   Name=FBN1 {ECO:0000250|UniProtKB:P35555};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RX   PubMed=10036187; DOI=10.1006/geno.1998.5697;
RA   Biery N.J., Eldadah Z.A., Moore C.S., Stetten G., Spencer F., Dietz H.C.;
RT   "Revised genomic organization of FBN1 and significance for regulated gene
RT   expression.";
RL   Genomics 56:70-77(1999).
CC   -!- FUNCTION: [Fibrillin-1]: Structural component of the 10-12 nm diameter
CC       microfibrils of the extracellular matrix, which conveys both structural
CC       and regulatory properties to load-bearing connective tissues.
CC       Fibrillin-1-containing microfibrils provide long-term force bearing
CC       structural support. In tissues such as the lung, blood vessels and
CC       skin, microfibrils form the periphery of the elastic fiber, acting as a
CC       scaffold for the deposition of elastin. In addition, microfibrils can
CC       occur as elastin-independent networks in tissues such as the ciliary
CC       zonule, tendon, cornea and glomerulus where they provide tensile
CC       strength and have anchoring roles. Fibrillin-1 also plays a key role in
CC       tissue homeostasis through specific interactions with growth factors,
CC       such as the bone morphogenetic proteins (BMPs), growth and
CC       differentiation factors (GDFs) and latent transforming growth factor-
CC       beta-binding proteins (LTBPs), cell-surface integrins and other
CC       extracellular matrix protein and proteoglycan components. Regulates
CC       osteoblast maturation by controlling TGF-beta bioavailability and
CC       calibrating TGF-beta and BMP levels, respectively. Negatively regulates
CC       osteoclastogenesis by binding and sequestering an osteoclast
CC       differentiation and activation factor TNFSF11. This leads to disruption
CC       of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated
CC       nuclear translocation and activation of transcription factor NFATC1
CC       which regulates genes important for osteoclast differentiation and
CC       function. Mediates cell adhesion via its binding to cell surface
CC       receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this
CC       interaction plays an important role in the assembly of microfibrils.
CC       {ECO:0000250|UniProtKB:P35555, ECO:0000250|UniProtKB:Q61554}.
CC   -!- FUNCTION: [Asprosin]: Hormone that targets the liver to increase plasma
CC       glucose levels. Secreted by white adipose tissue and circulates in the
CC       plasma. Acts in response to fasting and promotes blood glucose
CC       elevation by binding to the surface of hepatocytes. Promotes hepatocyte
CC       glucose release by activating the protein kinase A activity in the
CC       liver, resulting in rapid glucose release into the circulation.
CC       {ECO:0000250|UniProtKB:P35555}.
CC   -!- SUBUNIT: [Fibrillin-1]: Interacts with COL16A1. Interacts with integrin
CC       alpha-V/beta-3. Interacts with ADAMTS10; this interaction promotes
CC       microfibril assembly. Interacts with THSD4; this interaction promotes
CC       fibril formation. Interacts (via N-terminal domain) with FBLN2 and
CC       FBLN5. Interacts with ELN. Forms a ternary complex with ELN and FBLN2
CC       or FBLN5 and a significant interaction with ELN seen only in the
CC       presence of FBLN2 or FBLN5. Interacts (via N-terminal domain) with
CC       LTBP2 (via C-terminal domain) in a Ca(+2)-dependent manner. Interacts
CC       (via N-terminal domain) with LTBP1 (via C-terminal domain). Interacts
CC       with integrins ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. Interacts (via
CC       N-terminal domain) with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts
CC       (via N-terminal domain) with MFAP2 and MFAP5. Interacts with ADAMTSL5.
CC       Interacts with MFAP4. Interacts (via N-terminal domain) with TNFSF11 in
CC       a Ca(+2)-dependent manner. Interacts (via N-terminal domain) with
CC       EFEMP2; this interaction inhibits EFEMP2 binding to LOX and ELN (By
CC       similarity). {ECO:0000250|UniProtKB:P35555,
CC       ECO:0000250|UniProtKB:Q61554}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P35555}.
CC       Note=Fibrillin-1 and Asprosin chains are still linked together during
CC       the secretion from cells, but are subsequently separated by furin.
CC       {ECO:0000250|UniProtKB:P35555}.
CC   -!- SUBCELLULAR LOCATION: [Asprosin]: Secreted
CC       {ECO:0000250|UniProtKB:P35555}. Note=Secreted into the plasma.
CC       {ECO:0000250|UniProtKB:P35555}.
CC   -!- SUBCELLULAR LOCATION: [Fibrillin-1]: Secreted, extracellular space,
CC       extracellular matrix {ECO:0000250|UniProtKB:P35555}.
CC   -!- PTM: Cleavage of N- and C-terminus by furin is required for
CC       incorporation into the extracellular matrix and assembly into
CC       microfibrils. The C-terminus, which corresponds to the Asprosin chain,
CC       was initially thought to constitute a propeptide. Fibrillin-1 and
CC       Asprosin chains are still linked together during the secretion from
CC       cells, but are subsequently separated by furin, an essential step for
CC       incorporation of Fibrillin-1 into the nascent microfibrils.
CC       {ECO:0000250|UniProtKB:P35555}.
CC   -!- PTM: [Fibrillin-1]: Forms intermolecular disulfide bonds either with
CC       other fibrillin-1 molecules or with other components of the
CC       microfibrils. {ECO:0000250|UniProtKB:P35555}.
CC   -!- PTM: O-glycosylated on serine residues by POGLUT2 and POGLUT3 which is
CC       necessary for efficient protein secretion.
CC       {ECO:0000250|UniProtKB:P35555}.
CC   -!- SIMILARITY: Belongs to the fibrillin family. {ECO:0000305}.
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DR   EMBL; AF073800; AAD50328.1; -; mRNA.
DR   RefSeq; NP_001001771.1; NM_001001771.1.
DR   BMRB; Q9TV36; -.
DR   SMR; Q9TV36; -.
DR   STRING; 9823.ENSSSCP00000005017; -.
DR   PaxDb; Q9TV36; -.
DR   PeptideAtlas; Q9TV36; -.
DR   PRIDE; Q9TV36; -.
DR   GeneID; 414836; -.
DR   KEGG; ssc:414836; -.
DR   CTD; 2200; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   InParanoid; Q9TV36; -.
DR   OrthoDB; 1174178at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0001527; C:microfibril; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR   GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR   GO; GO:0034199; P:activation of protein kinase A activity; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR   GO; GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
DR   GO; GO:0010737; P:protein kinase A signaling; ISS:UniProtKB.
DR   Gene3D; 3.90.290.10; -; 9.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR011398; FBN.
DR   InterPro; IPR040872; Fibrillin_U_N.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR017878; TB_dom.
DR   InterPro; IPR036773; TB_dom_sf.
DR   PANTHER; PTHR24039:SF22; PTHR24039:SF22; 7.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 39.
DR   Pfam; PF18193; Fibrillin_U_N; 1.
DR   Pfam; PF00683; TB; 9.
DR   SMART; SM00181; EGF; 47.
DR   SMART; SM00179; EGF_CA; 44.
DR   SUPFAM; SSF57184; SSF57184; 10.
DR   SUPFAM; SSF57581; SSF57581; 9.
DR   PROSITE; PS00010; ASX_HYDROXYL; 41.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; 36.
DR   PROSITE; PS50026; EGF_3; 43.
DR   PROSITE; PS01187; EGF_CA; 41.
DR   PROSITE; PS51364; TB; 9.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; EGF-like domain; Extracellular matrix;
KW   Glycoprotein; Hormone; Phosphoprotein; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   PROPEP          25..44
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT                   /id="PRO_0000436885"
FT   CHAIN           45..2731
FT                   /note="Fibrillin-1"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT                   /id="PRO_0000007583"
FT   CHAIN           2732..2871
FT                   /note="Asprosin"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT                   /id="PRO_0000436886"
FT   DOMAIN          81..112
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          115..146
FT                   /note="EGF-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          147..178
FT                   /note="EGF-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          184..236
FT                   /note="TB 1"
FT   DOMAIN          246..287
FT                   /note="EGF-like 4; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          288..329
FT                   /note="EGF-like 5; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          334..389
FT                   /note="TB 2"
FT   DOMAIN          449..489
FT                   /note="EGF-like 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          490..529
FT                   /note="EGF-like 7; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          530..571
FT                   /note="EGF-like 8; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          572..612
FT                   /note="EGF-like 9; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          613..653
FT                   /note="EGF-like 10; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          659..711
FT                   /note="TB 3"
FT   DOMAIN          723..764
FT                   /note="EGF-like 11; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          765..806
FT                   /note="EGF-like 12; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          807..846
FT                   /note="EGF-like 13; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          851..902
FT                   /note="TB 4"
FT   DOMAIN          910..951
FT                   /note="EGF-like 14; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          956..1008
FT                   /note="TB 5"
FT   DOMAIN          1028..1069
FT                   /note="EGF-like 15; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1070..1112
FT                   /note="EGF-like 16; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1113..1154
FT                   /note="EGF-like 17; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1155..1196
FT                   /note="EGF-like 18; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1197..1237
FT                   /note="EGF-like 19; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1238..1279
FT                   /note="EGF-like 20; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1280..1321
FT                   /note="EGF-like 21; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1322..1362
FT                   /note="EGF-like 22; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1363..1403
FT                   /note="EGF-like 23; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1404..1445
FT                   /note="EGF-like 24; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1446..1486
FT                   /note="EGF-like 25; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1487..1527
FT                   /note="EGF-like 26; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1532..1589
FT                   /note="TB 6"
FT   DOMAIN          1606..1647
FT                   /note="EGF-like 27; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1648..1688
FT                   /note="EGF-like 28; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1693..1748
FT                   /note="TB 7"
FT   DOMAIN          1766..1807
FT                   /note="EGF-like 29; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1808..1848
FT                   /note="EGF-like 30; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1849..1890
FT                   /note="EGF-like 31; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1891..1929
FT                   /note="EGF-like 32; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1930..1972
FT                   /note="EGF-like 33; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1973..2012
FT                   /note="EGF-like 34; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2013..2054
FT                   /note="EGF-like 35; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2059..2111
FT                   /note="TB 8"
FT   DOMAIN          2127..2165
FT                   /note="EGF-like 36; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2166..2205
FT                   /note="EGF-like 37; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2206..2246
FT                   /note="EGF-like 38; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2247..2290
FT                   /note="EGF-like 39; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2291..2332
FT                   /note="EGF-like 40; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2337..2390
FT                   /note="TB 9"
FT   DOMAIN          2402..2443
FT                   /note="EGF-like 41; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2444..2484
FT                   /note="EGF-like 42; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2485..2523
FT                   /note="EGF-like 43; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2524..2566
FT                   /note="EGF-like 44; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2567..2606
FT                   /note="EGF-like 45; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2607..2647
FT                   /note="EGF-like 46; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2648..2687
FT                   /note="EGF-like 47; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REGION          29..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          45..450
FT                   /note="N-terminal domain"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   REGION          45..81
FT                   /note="Fibrillin unique N-terminal (FUN) domain"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   REGION          119..329
FT                   /note="Interaction with MFAP4"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   REGION          195..221
FT                   /note="Hybrid domain 1"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   REGION          862..887
FT                   /note="Hybrid domain 2"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   REGION          1528..2731
FT                   /note="C-terminal domain"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   MOTIF           1541..1543
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   SITE            44..45
FT                   /note="Cleavage; by furin"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   SITE            2731..2732
FT                   /note="Cleavage; by furin"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   MOD_RES         2702
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   MOD_RES         2709
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q61554"
FT   CARBOHYD        268
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        448
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        471
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        510
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1135
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1218
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1302
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1345
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1347
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1369
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1386
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1484
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1508
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1581
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1628
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1669
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1703
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1713
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1830
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1871
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1902
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1911
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        1953
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        2035
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        2077
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2148
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        2178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2227
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        2313
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        2465
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        2547
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        2628
FT                   /note="O-linked (Glc) serine"
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   CARBOHYD        2734
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2750
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2767
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        59..68
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   DISULFID        67..80
FT                   /evidence="ECO:0000250|UniProtKB:P35555"
FT   DISULFID        85..94
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        89..100
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        102..111
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        119..129
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        123..134
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        136..145
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        150..160
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        154..166
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        168..177
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        250..262
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        257..271
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        273..286
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        292..304
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        299..313
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        315..328
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        453..465
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        460..474
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        476..488
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        494..504
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        499..513
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        515..528
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        534..546
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        541..555
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        557..570
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        576..587
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        582..596
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        598..611
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        617..628
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        623..637
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        639..652
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        727..739
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        734..748
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        750..763
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        769..781
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        776..790
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        792..805
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        811..821
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        816..830
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        832..845
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        853..875
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        862..887
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        876..890
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        896..908
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        914..926
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        921..935
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        937..950
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1032..1044
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1039..1053
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1055..1068
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1074..1086
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1081..1095
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1097..1111
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1117..1129
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1124..1138
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1140..1153
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1159..1171
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1201..1212
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1208..1221
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1223..1236
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1242..1254
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1249..1263
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1265..1278
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1284..1296
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1291..1305
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1307..1320
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1326..1339
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1333..1348
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1350..1361
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1367..1380
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1374..1389
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1391..1402
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1408..1420
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1415..1429
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1450..1461
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1456..1470
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1472..1485
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1491..1502
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1497..1511
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1513..1526
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1534..1562
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1549..1574
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1563..1577
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1564..1589
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1610..1622
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1617..1631
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1633..1646
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1652..1663
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1658..1672
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1674..1687
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1770..1782
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1777..1791
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1793..1806
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1812..1824
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1818..1833
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1835..1847
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1853..1865
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1860..1874
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1876..1889
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1895..1905
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1900..1914
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1916..1928
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1934..1947
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1942..1956
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1958..1971
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1977..1989
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        1984..1998
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2000..2011
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2017..2029
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2024..2038
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2040..2053
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2061..2083
FT                   /evidence="ECO:0000250|UniProtKB:P35555,
FT                   ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2070..2096
FT                   /evidence="ECO:0000250|UniProtKB:P35555,
FT                   ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2084..2099
FT                   /evidence="ECO:0000250|UniProtKB:P35555,
FT                   ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2085..2111
FT                   /evidence="ECO:0000250|UniProtKB:P35555,
FT                   ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2131..2142
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2137..2151
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2153..2164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2170..2181
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2176..2190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2192..2204
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2210..2221
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2217..2230
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2232..2245
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2251..2265
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2258..2274
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2276..2289
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2295..2307
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2302..2316
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2318..2331
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2406..2418
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2413..2427
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2429..2442
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2448..2459
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2455..2468
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2470..2483
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2489..2500
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2496..2509
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2511..2522
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2528..2541
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2535..2550
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2552..2565
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2571..2581
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2577..2590
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2592..2605
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2611..2622
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2617..2631
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2633..2646
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2652..2663
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2659..2672
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        2674..2686
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   2871 AA;  312699 MW;  7A0E40FA8CA65F07 CRC64;
     MRRGRLLEVA LGFTVLLASY TSHRAEANLE AGNGKETRAS RAKRRGGGGH DALKGPNVCG
     SRYNAYCCPG WKTLPGGNQC IVPICRHSCG DGFCSRPNMC TCPSGQIAPS CGSRSIQHCN
     IRCMNGGSCS DDHCLCQKGY IGTHCGQPVC ESGCLNGGRC VAPNRCACTY GFTGPQCERD
     YRTGPCFTVV SNQMCQGQLS GIVCTKTLCC ATVGRAWGHP CEMCPAQPHP CRRGFIPNIR
     TGACQDVDEC QAIPGLCQGG NCINTVGSFE CKCPAGHKFN EVSQKCEDID ECSTIPGICD
     GGECTNTVSS YFCKCPPGFY TSPDGTRCID VRPGYCYTAL TNGRCSNQLP QSITKMQCCC
     DVGRCWSPGV TVTPEMCPIR ATEDFNKLCS VPMVVPERPG YPSPPLGPIP PVHPVPPGFP
     PGPQIPVPRP PVEYPYPSRE PPRVLPVNVT DYCQLFRYLC HNGRCIPTPG SYRCECNKGF
     QLDLRGECID VDECEKNPCA GGECINNQGS YTCQCRPGYQ STLTRTECRD IDECLQNGRI
     CNNGRCINTD GSFHCVCNAG FHVTRDGKNC EDMDECSIRN MCLNGMCINE DGSFKCICKP
     GFQLASDGRY CKDINECETS GICMNGRCVN TDGSYRCECF PGLAVGLDGR VCVDTHMRST
     CYGGYKRGQC VKPLFGAVTK SECCCASTEY AFGEPCQPCP SQNSAEYQAL CSSGPGMTSA
     GSDINECALD PDICPNGICE NLRGTYKCIC NSGYEVDSTG KNCVDINECV LNSLLCDNGQ
     CRNTPGSFVC TCPKGFIYKP DLKTCEDIDE CESSPCINGV CKNSPGSFIC ECSSESTLDP
     TKTICIETIK GTCWQTIIDG RCEININGAT LKSQCCSSLG AAWGSPCTPC QVDPICGKGY
     SRIKGTQCED IDECEVFPGV CKNGLCVNSK GSFKCQCPNG MTLDATGRIC LDIRLETCFL
     RYEDEECTLP VVGRHRMDAC CCSVGAAWGT EECEECPPRN TPEYEELCPR GPGFATKEIT
     NGKPFFKDIN ECKMIPNLCT HGKCRNTIGS FKCRCDSGFA LDSEERNCID IDECRISPDL
     CGRGQCVNTP GDFECKCDEG YESGFMMMKN CMDIDECQRD PLLCRGGVCL NTEGSYRCEC
     PSGHQMSPNI SACIDINECE LSAHLCPHGR CVNLIGKYQR ARNPGYHSTP DRLFCVDIDE
     CSIMNGGCET FCTNSEGSYE CSCQPGFALM PDQRSCTDID ECEDNPNICD GGQCTNIPGE
     YRCLCYDGFM ASEDMKTCVD VNECDLNPNI CLSGTCENTK GSFICHCDMG YSGKKGKTGC
     TDINECEIGA HNCDRHAVCT NTAGSFNCSC SPGWIGDGIK CTDLDECSNG THMCSQHADC
     KNTMGSYRCL CKEGYTGDGF TCADLDECSE NVKLCGNVQC LYAPGGYHCE YDMGFVPSAD
     RKSCVDSDEC SLPNICVFGT CHNLPGLFRC ECEIGYELDR SGGNCTDVNE CLEPPTCISG
     NCVNTPGSYT CVCPPDFELN PTRVGCVDTR SGNCYLDVRP RGDNGDTACS NEIGVGVSKA
     SCCCSLGKAW GTPCEQCPPV NTSEYKILCP GGEGFRPNPI TVILEDIDEC QELPGLCQGG
     KCINTFGSFQ CRCPTGYYLN EDTRVCDDVN ECETPGICGP GTCYNTVGNY TCICPPDYMQ
     VNGGNNCMDM RRSLCYRNYY ADNQTCDGEL LFNMTKKMCC CSYNIGRAWN KPCEQCPIPS
     TDEFATLCGS QRPGFVIDIY TGLPVDIDEC REIPGVCENG VCINMVGSFR CECPVGFFYN
     DKLLVCEDID ECQNGPVCQR NAECINTAGS YRCDCKPGYR FTSTGQCNDR NECQEIPNIC
     SHGQCIDTVG SFYCLCHTGF KTNADQTMCL DINECERDAC GNGTCRNTIG SFNCRCNHGF
     ILSHNNDCID VDECATGNGN LCRNGQCINT VGSFQCQCNE GYEVAPDGRT CVDINECLLE
     PGKCAPGTCQ NLDGSYRCIC PPGYSLQNDK CEDIDECVEE PEICALGTCS NTEGSFKCLC
     PDGFSLSSTG RRCQDLRMSY CYAKFEGGKC SSPKSRNHSK QECCCALKGE GWGDPCELCP
     TEPDEAFRQI CPYGSGIIVG PDDSAVDMDE CKEPDVCKHG QCINTDGSYR CECPFGYILE
     GNECVDTDEC SVGNPCGNGT CKNVIGGFEC TCEEGFEPGP MMTCEDINEC AQNPLLCAFR
     CVNTYGSYEC KCPTGYVLRE DRRMCKDEDE CEEGKHDCAE KQMECKNLIG MYICICGPGY
     QRRPDGEGCV DENECQTKPG ICENGRCLNT RGSYTCECND GFTASPTQDE CLDNREGYCF
     TEVLQNMCQI GSSNRNPVTK SECCCDGGRG WGPHCEICPF QGTVAFKKLC PHGRGFMTNG
     ADIDECKVIH DVCRNGECIN DRGSYHCICK TGYTPDITGT ACVDLNECNQ APKPCNFICK
     NTEGSYQCSC PKGYILQEDG RSCKDLDECA TKQHNCQFLC VNTIGSFACK CPPGFTQHHT
     ACIDNNECTS DINLCGAKGI CQNTPGSFTC ECQRGFSLDQ SGASCEDVDE CEGNHRCQHG
     CQNIIGGYRC SCPQGYLQHY QWNQCVDENE CLSAHICGGA SCHNTLGSYK CMCPAGFQYE
     QFSGGCQDIN ECGSSQAPCS YGCSNTEGGY LCGCPPGYFR IGQGHCVSGM GMGRGSPEPP
     ASGEMDDNSL SPEACYECKI NGYPKRGRKR RSTNETDAFN IEDQPETESN VSLASWDVEK
     TAVFAFNISH ISNKVRILEL LPALTTLTNH NRYLIESGNE NGFFKINQKE GISYLHFTKK
     KPVAGTYSLQ ISSTPLYKKK ELNQLEDKYD KDYLSGELGD NLKMKIQILL H
 
 
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