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FBP12_MOUSE
ID   FBP12_MOUSE             Reviewed;         132 AA.
AC   Q9DAK4; B7SUM9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Fatty acid-binding protein 12;
GN   Name=Fabp12;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J; TISSUE=Retina;
RX   PubMed=18786628; DOI=10.1016/j.ygeno.2008.08.003;
RA   Liu R.Z., Li X., Godbout R.;
RT   "A novel fatty acid-binding protein (FABP) gene resulting from tandem gene
RT   duplication in mammals: transcription in rat retina and testis.";
RL   Genomics 92:436-445(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Retina;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in lipid transport. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in adult retina and testis.
CC       {ECO:0000269|PubMed:18786628}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family. {ECO:0000305}.
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DR   EMBL; EU733649; ACI03639.1; -; mRNA.
DR   EMBL; AK005765; BAB24227.1; -; mRNA.
DR   EMBL; CH466577; EDL05167.1; -; Genomic_DNA.
DR   EMBL; CH466577; EDL05168.1; -; Genomic_DNA.
DR   EMBL; BC030910; AAH30910.1; -; mRNA.
DR   CCDS; CCDS17239.1; -.
DR   RefSeq; NP_083586.1; NM_029310.1.
DR   RefSeq; XP_006530156.1; XM_006530093.3.
DR   RefSeq; XP_006530157.1; XM_006530094.3.
DR   RefSeq; XP_006530158.1; XM_006530095.3.
DR   RefSeq; XP_006530159.1; XM_006530096.3.
DR   RefSeq; XP_006530160.1; XM_006530097.3.
DR   RefSeq; XP_006530162.1; XM_006530099.3.
DR   RefSeq; XP_017175272.1; XM_017319783.1.
DR   AlphaFoldDB; Q9DAK4; -.
DR   SMR; Q9DAK4; -.
DR   STRING; 10090.ENSMUSP00000029043; -.
DR   PhosphoSitePlus; Q9DAK4; -.
DR   PaxDb; Q9DAK4; -.
DR   PRIDE; Q9DAK4; -.
DR   ProteomicsDB; 272958; -.
DR   Antibodypedia; 49988; 69 antibodies from 16 providers.
DR   DNASU; 75497; -.
DR   Ensembl; ENSMUST00000029043; ENSMUSP00000029043; ENSMUSG00000027530.
DR   Ensembl; ENSMUST00000117917; ENSMUSP00000112464; ENSMUSG00000027530.
DR   Ensembl; ENSMUST00000119761; ENSMUSP00000112958; ENSMUSG00000027530.
DR   Ensembl; ENSMUST00000172126; ENSMUSP00000131101; ENSMUSG00000027530.
DR   GeneID; 75497; -.
DR   KEGG; mmu:75497; -.
DR   UCSC; uc008opm.1; mouse.
DR   CTD; 646486; -.
DR   MGI; MGI:1922747; Fabp12.
DR   VEuPathDB; HostDB:ENSMUSG00000027530; -.
DR   eggNOG; KOG4015; Eukaryota.
DR   GeneTree; ENSGT00940000162398; -.
DR   HOGENOM; CLU_113772_0_0_1; -.
DR   InParanoid; Q9DAK4; -.
DR   OMA; MVVESSV; -.
DR   OrthoDB; 1417203at2759; -.
DR   PhylomeDB; Q9DAK4; -.
DR   TreeFam; TF316894; -.
DR   Reactome; R-MMU-163560; Triglyceride catabolism.
DR   BioGRID-ORCS; 75497; 5 hits in 74 CRISPR screens.
DR   PRO; PR:Q9DAK4; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q9DAK4; protein.
DR   Bgee; ENSMUSG00000027530; Expressed in retinal neural layer and 34 other tissues.
DR   Genevisible; Q9DAK4; MM.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR   GO; GO:0015908; P:fatty acid transport; IBA:GO_Central.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR031261; FABP12.
DR   InterPro; IPR000463; Fatty_acid-bd.
DR   InterPro; IPR031259; ILBP.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11955; PTHR11955; 1.
DR   PANTHER; PTHR11955:SF76; PTHR11955:SF76; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR00178; FATTYACIDBP.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Lipid-binding; Reference proteome; Transport.
FT   CHAIN           1..132
FT                   /note="Fatty acid-binding protein 12"
FT                   /id="PRO_0000342882"
FT   BINDING         107
FT                   /ligand="a fatty acid"
FT                   /ligand_id="ChEBI:CHEBI:28868"
FT                   /evidence="ECO:0000250"
FT   BINDING         127..129
FT                   /ligand="a fatty acid"
FT                   /ligand_id="ChEBI:CHEBI:28868"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   132 AA;  14758 MW;  7A20C53780845F61 CRC64;
     MVDQLQGTWK SVSCDNFENY MKELGVGRAS RKLGCLAKPT VTISTDGDLI TIKTKSIFKN
     KEISFKLGEE FEETTPSGRK SKSTVILDND SLVQVQDWDG KEATICRRLV DGKMVVESAV
     NNVTCTRTYQ RV
 
 
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