FBP1_DROME
ID FBP1_DROME Reviewed; 1029 AA.
AC Q04691; Q86PB6; Q8IQL4; Q9VUD0;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Fat-body protein 1;
DE Short=P1 protein;
DE Flags: Precursor;
GN Name=Fbp1; Synonyms=P1; ORFNames=CG17285;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oregon-R; TISSUE=Fat body;
RX PubMed=1696317; DOI=10.1016/0022-2836(90)90186-p;
RA Maschat F., Dubertret M.-L., Therond P., Claverie J.-M., Lepesant J.-A.;
RT "Structure of the ecdysone-inducible P1 gene of Drosophila melanogaster.";
RL J. Mol. Biol. 214:359-372(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Canton-S;
RX PubMed=8293980; DOI=10.1093/genetics/135.3.801;
RA Lapie P., Nasr F., Lepesant J.-A., Deutsch J.;
RT "Deletion scanning of the regulatory sequences of the Fbp1 gene of
RT Drosophila melanogaster using P transposase-induced deficiencies.";
RL Genetics 135:801-816(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q04691-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q04691-2; Sequence=VSP_014264;
CC -!- TISSUE SPECIFICITY: Fat body.
CC -!- DEVELOPMENTAL STAGE: Expressed during the late third larval stage.
CC -!- INDUCTION: By ecdysone.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO24985.1; Type=Frameshift; Note=The frameshift is due to large deletion.; Evidence={ECO:0000305};
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DR EMBL; X54997; CAA38744.1; -; Genomic_DNA.
DR EMBL; X69965; CAA49588.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF49757.2; -; Genomic_DNA.
DR EMBL; AE014296; AAN11802.1; -; Genomic_DNA.
DR EMBL; AY119088; AAM50948.1; -; mRNA.
DR EMBL; BT003568; AAO39572.1; -; mRNA.
DR EMBL; BT003230; AAO24985.1; ALT_SEQ; mRNA.
DR PIR; S11034; S11034.
DR RefSeq; NP_524065.1; NM_079341.2. [Q04691-1]
DR RefSeq; NP_729959.1; NM_168578.2. [Q04691-2]
DR AlphaFoldDB; Q04691; -.
DR BioGRID; 64902; 2.
DR IntAct; Q04691; 3.
DR STRING; 7227.FBpp0075491; -.
DR PaxDb; Q04691; -.
DR PRIDE; Q04691; -.
DR DNASU; 39566; -.
DR EnsemblMetazoa; FBtr0075749; FBpp0075491; FBgn0000639. [Q04691-1]
DR EnsemblMetazoa; FBtr0075750; FBpp0075492; FBgn0000639. [Q04691-2]
DR GeneID; 39566; -.
DR KEGG; dme:Dmel_CG17285; -.
DR CTD; 2203; -.
DR FlyBase; FBgn0000639; Fbp1.
DR VEuPathDB; VectorBase:FBgn0000639; -.
DR eggNOG; ENOG502QR98; Eukaryota.
DR GeneTree; ENSGT00940000165243; -.
DR InParanoid; Q04691; -.
DR OMA; QGIDRMS; -.
DR PhylomeDB; Q04691; -.
DR SignaLink; Q04691; -.
DR BioGRID-ORCS; 39566; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Fbp1; fly.
DR GenomeRNAi; 39566; -.
DR PRO; PR:Q04691; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0000639; Expressed in saliva-secreting gland and 14 other tissues.
DR ExpressionAtlas; Q04691; baseline and differential.
DR Genevisible; Q04691; DM.
DR Gene3D; 1.20.1370.10; -; 1.
DR Gene3D; 2.60.40.1520; -; 1.
DR InterPro; IPR013788; Hemocyanin/hexamerin.
DR InterPro; IPR005203; Hemocyanin_C.
DR InterPro; IPR037020; Hemocyanin_C_sf.
DR InterPro; IPR005204; Hemocyanin_N.
DR InterPro; IPR036697; Hemocyanin_N_sf.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR11511; PTHR11511; 1.
DR Pfam; PF03723; Hemocyanin_C; 1.
DR Pfam; PF03722; Hemocyanin_N; 1.
DR SUPFAM; SSF48050; SSF48050; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..1029
FT /note="Fat-body protein 1"
FT /id="PRO_0000021232"
FT VAR_SEQ 1..32
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_014264"
FT CONFLICT 83
FT /note="H -> Q (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="F -> L (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 160
FT /note="A -> T (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="W -> Q (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="Q -> R (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="Q -> N (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 324..331
FT /note="LLRVSRRR -> PTPCESAAG (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="H -> R (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 519
FT /note="H -> N (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 533..537
FT /note="VMGER -> RHGRA (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 581
FT /note="D -> Y (in Ref. 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 585
FT /note="V -> D (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 695
FT /note="N -> S (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 742
FT /note="I -> S (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 748
FT /note="T -> N (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 898
FT /note="H -> Q (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 979
FT /note="V -> I (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1029 AA; 119663 MW; 555168D01768B8CC CRC64;
MNRIMLLVAF AAGVVAAGRI TTNQDRVQGI DRMSLEDLQL QKFILDIVQN IRQPLQQSEL
INLDVGLIAD SQRYRGGIDK VMHNVIDLDR QRRLLDEHQV YSVGRLEHVQ QLRGIYRLLA
RAQDFDTLRR NVVYLRRNIN PVLLVNALAL AIRDREDTQA LIVPAVQELL PELYLDEEVI
QQVRSVLREQ TQRPSLMDIV GMRQRAMNPV MSILMPWREI HMQMALRKQQ NIQNVLGQKR
VVVRAENQGQ VEGTSLLTDD IELQNFVQNL IQELALLEDV TQLEQSQLIN NDQREEQWVG
RQRVQYQDNN QERDLGQDVD TGRLLRVSRR RLLEQQDEYQ GQNIYGNQKD RFQRLLRRDD
DNDDNDDDDD QDIRMGRVQL QRGISQGGLR IGGAHNLPTV SVNSDRLLHV SRRRLNAIQQ
DQQQDQLNGR QRFMGLVRGD RLSEGRRVGQ LDDVRQERQN NWQKQDYILT QGRTFGVQQE
RQNYADQLES VSRDDERLVH INRRRLNQDN QDIQQQQMHF PRRINSIGEG RRVMGERPIQ
DEDILKLIRG ENRLKLMTDD EILEMLQRNR QQRLQKHQND DDDDVNDDDV NVVHRQGLRS
RRSLPNLRQQ NNRLSEIVLH NLRQLVARLN QESIAQGQLI EEQQQLINNP RLTQSERYAL
RLNQIRINSQ RSRQVLAQIG QIEQRIQEVI GQVLNQVNVN SLRGQVIDQR QVESLIADVL
LGRLGQVGIM TIIRQVVQDN NIEQIDRTGL GIRLSDPVVQ YTLRRIVRIV DEQREQILGG
YRQEQLQMRG VSINDVRVDK LRTRIEEHEL DLSNLVEQQV QGIQQEIVGR QRRLNNKAFT
IDMDITSDQD QDAIIRIFLG PAEDQQGRQG ASLDERRRDF VLLDAIQVQL ENGRNRIHRR
SIDIPWTTSD VTPLVEIYRQ VMLQLKGQQA QQVVGIQQLV GENGRFPQHL LLPRGRPEGL
PMQLLVVVSP LVELQVQDVV PAITIGIGSA SLRDARPLGY PLDRPIHNEQ ELLQLTNVLL
QDVVIIQEN
