ID   FBP2_DROSI              Reviewed;         256 AA.
AC   O61510;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Fat body protein 2;
GN   Name=Fbp2;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Dm;
RX   PubMed=10331261; DOI=10.1093/oxfordjournals.molbev.a026115;
RA   Benassi V., Depaulis F., Meghlaoui G.K., Veuille M.;
RT   "Partial sweeping of variation at the Fbp2 locus in a west African
RT   population of Drosophila melanogaster.";
RL   Mol. Biol. Evol. 16:347-353(1999).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AF045786; AAC15684.1; -; Genomic_DNA.
DR   AlphaFoldDB; O61510; -.
DR   SMR; O61510; -.
DR   ChiTaRS; Fbp2; fly.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0045735; F:nutrient reservoir activity; ISS:UniProtKB.
DR   InterPro; IPR002426; ADH_Ceratitis-type.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01169; CERATITISADH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..256
FT                   /note="Fat body protein 2"
FT                   /id="PRO_0000277831"
FT   ACT_SITE        151
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         10..34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         138
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   256 AA;  29037 MW;  06B1DFB1602E1C36 CRC64;
     MFDWTGKNVV YVGSFSGIGW QMMMQLMQKD IKMMGIMHRM ENVEMMKKLQ AINPSVKVVF
     MQMNLMGKMS IDQAMKKMGQ MMGHIDVMIN GEGVLLDKDV ETTMGMNLTG MIHSTMMAMP
     YMDKTQMGMG GMVVNMSSVY GLEPAHAFAV YAAAMHGILG FTRSMGDKMI YQKTGVMFMA
     MCPGLTNSEM MMNLRDNVTW HHSESMVEAI ESAKRQMPEE AAMQMIHAME MMKNGSMWIV
     NMGQLKEVMP TMHWQM