ID   FBP2_STRPU              Reviewed;         325 AA.
AC   P15216;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Fibropellin-2;
DE   AltName: Full=Epidermal growth factor-related protein 2;
DE   AltName: Full=Fibropellin II;
DE   Flags: Precursor;
GN   Name=EGF2;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2814501; DOI=10.1126/science.2814501;
RA   Yang O., Angerer L.M., Angerer R.C.;
RT   "Unusual pattern of accumulation of mRNA encoding EGF-related protein in
RT   sea urchin embryos.";
RL   Science 246:806-808(1989).
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DR   EMBL; M29004; AAA30044.1; -; mRNA.
DR   PIR; A40084; A40084.
DR   RefSeq; NP_999696.1; NM_214531.1.
DR   AlphaFoldDB; P15216; -.
DR   EnsemblMetazoa; NM_214531; NP_999696; GeneID_373304.
DR   GeneID; 373304; -.
DR   KEGG; spu:373304; -.
DR   CTD; 373304; -.
DR   HOGENOM; CLU_1973302_0_0_1; -.
DR   OrthoDB; 1606942at2759; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   SMART; SM00181; EGF; 4.
DR   PROSITE; PS01186; EGF_2; 4.
DR   PROSITE; PS50026; EGF_3; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; EGF-like domain; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..325
FT                   /note="Fibropellin-2"
FT                   /id="PRO_0000007587"
FT   DOMAIN          48..91
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          107..152
FT                   /note="EGF-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          178..224
FT                   /note="EGF-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          252..293
FT                   /note="EGF-like 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        52..65
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        59..75
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        77..90
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        111..124
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        118..137
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        139..151
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        182..195
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        189..209
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        211..223
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        256..269
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        263..278
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        280..292
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   325 AA;  36898 MW;  F09BA8805654C7AC CRC64;
     MQFNLVFVVA VIGVGMVAAD ENLMSKLQMA LKSMLNENEE LQMQSRDTKG QCESDTNKCN
     NHGTCIEGRW GTYYCKCEMP FRVGIPDSSC YPPPEGKKDL EIEARDSENR CLSDTSNCDG
     HGICQLSTFG RNERYICFCA LGFRNNNYGG CSPYTPREIE FLSYVARDLE LEMLTRDSLG
     RCKSDTHNCD EAGQCVTKTY GRYAGEYICV CNHGYRNNAY GGCSPMTTRE IEYLDMLARE
     EQMQMLVRKY YSLSECSQGT NDCNENGECV EEDGKYWCEC GEGYEENEDG GCSPIVTRAT
     EVDDDDFAER KKEIMRQLAE FLQEE