FBPA_NEIMA
ID FBPA_NEIMA Reviewed; 331 AA.
AC P0A0Y3; A1IQP8; P17940;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Major ferric iron-binding protein;
DE Short=FBP;
DE AltName: Full=Iron(III) periplasmic-binding protein;
DE AltName: Full=Major iron-regulated protein;
DE Short=MIRP;
DE Flags: Precursor;
GN Name=fbpA; Synonyms=fbp; OrderedLocusNames=NMA0844;
OS Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS Z2491).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122587;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=80084313 / Serogroup A;
RX PubMed=2117747; DOI=10.1093/nar/18.15.4596;
RA Berish S.A., Kapczynski D.R., Morse S.A.;
RT "Nucleotide sequence of the Fbp gene from Neisseria meningitidis.";
RL Nucleic Acids Res. 18:4596-4596(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15465 / Z2491;
RX PubMed=10761919; DOI=10.1038/35006655;
RA Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA Barrell B.G.;
RT "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT Z2491.";
RL Nature 404:502-506(2000).
RN [3]
RP PROTEIN SEQUENCE OF 23-69.
RC STRAIN=80084313 / Serogroup A;
RX PubMed=3130784; DOI=10.1007/bf00415504;
RA Morse S.A., Mietzner T.A., Bolen G., Le Faou A., Schoolnik G.;
RT "Characterization of the major iron-regulated protein of Neisseria
RT gonorrhoeae and Neisseria meningitidis.";
RL Antonie Van Leeuwenhoek 53:465-469(1987).
CC -!- FUNCTION: This protein may be a central component in the iron-
CC acquisition system.
CC -!- SUBCELLULAR LOCATION: Periplasm.
CC -!- INDUCTION: By iron deprivation.
CC -!- MISCELLANEOUS: Iron co-purifies with FBP and is bound by the protein as
CC a Fe(3+) ion at an approximate molar ratio of 1:1.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC {ECO:0000305}.
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DR EMBL; X53467; CAA37561.1; -; Genomic_DNA.
DR EMBL; AL157959; CAM08082.1; -; Genomic_DNA.
DR PIR; H81929; H81929.
DR PIR; S10978; B60816.
DR RefSeq; WP_002229166.1; NC_003116.1.
DR AlphaFoldDB; P0A0Y3; -.
DR SMR; P0A0Y3; -.
DR EnsemblBacteria; CAM08082; CAM08082; NMA0844.
DR GeneID; 61280865; -.
DR KEGG; nma:NMA0844; -.
DR HOGENOM; CLU_026974_2_0_4; -.
DR OMA; HPYNVSL; -.
DR BioCyc; NMEN122587:NMA_RS04235-MON; -.
DR Proteomes; UP000000626; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR026045; Ferric-bd.
DR InterPro; IPR006059; SBP.
DR InterPro; IPR006061; SBP_1_CS.
DR Pfam; PF01547; SBP_bac_1; 1.
DR PIRSF; PIRSF002825; CfbpA; 1.
DR PROSITE; PS01037; SBP_BACTERIAL_1; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Ion transport; Iron; Iron transport;
KW Metal-binding; Periplasm; Signal; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:3130784"
FT CHAIN 23..331
FT /note="Major ferric iron-binding protein"
FT /id="PRO_0000031691"
FT BINDING 31
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 79
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 217
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 218
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT CONFLICT 186
FT /note="G -> A (in Ref. 1; CAA37561)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="I -> V (in Ref. 1; CAA37561)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="Missing (in Ref. 1; CAA37561)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="S -> G (in Ref. 1; CAA37561)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 331 AA; 35842 MW; 70CBD2FA3366C026 CRC64;
MKTSIRYALL AAALTAATPA LADITVYNGQ HKEAAQAVAD AFTRATGIKV KLNSAKGDQL
AGQIKEEGSR SPADVFYSEQ IPALATLSAA NLLEPLPAST INETRGKGVP VAAKKDWVAL
SGRSRVVVYD TRKLSEKDLE KSVLNYATPK WKNRIGYAPT SGAFLEQVVA IVKLKGEAAA
LKWLKGLKEY GKPYAKNSVA LQAVENGEID AALINNYYWH AFAREKGVQN VHTRLNFVRH
RDPGALITYS GAAVLKSSQN KDEAKKFVAF LASKEGQRAL TAVRAEYPLN PHVVSTFNLE
PIAKLEAPQV SATTVSEKEH ATRLLEQAGM K