ID   FBPA_NEIMB              Reviewed;         331 AA.
AC   P0A0Y4; P17940;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Major ferric iron-binding protein;
DE            Short=FBP;
DE   AltName: Full=Iron(III) periplasmic-binding protein;
DE   AltName: Full=Major iron-regulated protein;
DE            Short=MIRP;
DE   Flags: Precursor;
GN   Name=fbpA; Synonyms=fbp; OrderedLocusNames=NMB0634;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17038831; DOI=10.4161/hv.1.2.1651;
RA   Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.;
RT   "Characterization of the protein content of a meningococcal outer membrane
RT   vesicle vaccine by polyacrylamide gel electrophoresis and mass
RT   spectrometry.";
RL   Hum. Vaccin. 1:80-84(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=NZ98/254 / Serogroup B;
RX   PubMed=16645985; DOI=10.1002/pmic.200500821;
RA   Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.;
RT   "Proteomic analysis of a meningococcal outer membrane vesicle vaccine
RT   prepared from the group B strain NZ98/254.";
RL   Proteomics 6:3400-3413(2006).
CC   -!- FUNCTION: This protein may be a central component in the iron-
CC       acquisition system. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: Present in outer membrane vesicle formulations which are
CC       used as vaccines in human.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE002098; AAF41057.1; -; Genomic_DNA.
DR   PIR; D81177; D81177.
DR   RefSeq; NP_273677.1; NC_003112.2.
DR   RefSeq; WP_002214250.1; NC_003112.2.
DR   AlphaFoldDB; P0A0Y4; -.
DR   SMR; P0A0Y4; -.
DR   STRING; 122586.NMB0634; -.
DR   PaxDb; P0A0Y4; -.
DR   EnsemblBacteria; AAF41057; AAF41057; NMB0634.
DR   KEGG; nme:NMB0634; -.
DR   PATRIC; fig|122586.8.peg.802; -.
DR   HOGENOM; CLU_026974_2_0_4; -.
DR   OMA; HPYNVSL; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR026045; Ferric-bd.
DR   InterPro; IPR006059; SBP.
DR   InterPro; IPR006061; SBP_1_CS.
DR   Pfam; PF01547; SBP_bac_1; 1.
DR   PIRSF; PIRSF002825; CfbpA; 1.
DR   PROSITE; PS01037; SBP_BACTERIAL_1; 1.
PE   1: Evidence at protein level;
KW   Ion transport; Iron; Iron transport; Metal-binding; Periplasm;
KW   Reference proteome; Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..331
FT                   /note="Major ferric iron-binding protein"
FT                   /id="PRO_0000031692"
FT   BINDING         31
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         79
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         217
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         218
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   331 AA;  35828 MW;  3FD53DFA251C7CE0 CRC64;
     MKTSIRYALL AAALTAATPA LADITVYNGQ HKEAAQAVAD AFTRATGIKV KLNSAKGDQL
     AGQIKEEGSR SPADVFYSEQ IPALATLSAA NLLEPLPAST INETRGKGVP VAAKKDWVAL
     SGRSRVVVYD TRKLSEKDLE KSVLNYATPK WKNRIGYAPT SGAFLEQVVA IVKLKGEAAA
     LKWLKGLKEY GKPYAKNSVA LQAVENGEID AALINNYYWH AFAREKGVQN VHTRLNFVRH
     RDPGALVTYS GAAVLKSSQN KDEAKKFVAF LASKEGQRAL TAVRAEYPLN PHVVSTFNLE
     PIAKLEAPQV SATTVSEKEH ATRLLEQAGM K