FBPA_SERMA
ID FBPA_SERMA Reviewed; 338 AA.
AC P21408;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Fe(3+)-binding periplasmic protein;
DE AltName: Full=Iron(III)-binding periplasmic protein;
DE Flags: Precursor;
GN Name=fbpA; Synonyms=sfuA;
OS Serratia marcescens.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=615;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2404942; DOI=10.1128/jb.172.2.572-578.1990;
RA Angerer A., Gaisser S., Braun V.;
RT "Nucleotide sequences of the sfuA, sfuB, and sfuC genes of Serratia
RT marcescens suggest a periplasmic-binding-protein-dependent iron transport
RT mechanism.";
RL J. Bacteriol. 172:572-578(1990).
CC -!- FUNCTION: Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1)
CC involved in Fe(3+) ions import. This protein specifically binds Fe(3+)
CC and is involved in its transmembrane transport (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FbpC),
CC two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC {ECO:0000305}.
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DR EMBL; M33815; AAA26573.1; -; Genomic_DNA.
DR PIR; A35108; QRSEUA.
DR RefSeq; WP_016927639.1; NZ_VOUR01000004.1.
DR PDB; 1XVY; X-ray; 1.74 A; A=30-338.
DR PDBsum; 1XVY; -.
DR AlphaFoldDB; P21408; -.
DR SMR; P21408; -.
DR STRING; 273526.SMDB11_1779; -.
DR DrugBank; DB04272; Citric acid.
DR TCDB; 3.A.1.10.1; the atp-binding cassette (abc) superfamily.
DR PATRIC; fig|615.99.peg.2970; -.
DR EvolutionaryTrace; P21408; -.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR026045; Ferric-bd.
DR InterPro; IPR006061; SBP_1_CS.
DR PIRSF; PIRSF002825; CfbpA; 1.
DR PROSITE; PS01037; SBP_BACTERIAL_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Ion transport; Iron; Iron transport; Metal-binding;
KW Periplasm; Signal; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..338
FT /note="Fe(3+)-binding periplasmic protein"
FT /id="PRO_0000031704"
FT BINDING 40
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 88
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 224
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 225
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT STRAND 33..37
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 41..55
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 59..63
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 66..76
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 77..79
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 83..86
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 88..90
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 91..98
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 107..110
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 115..117
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 123..136
FT /evidence="ECO:0007829|PDB:1XVY"
FT TURN 138..140
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 143..145
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 150..154
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 156..158
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 161..164
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 169..197
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 198..200
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 204..212
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 215..222
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 224..231
FT /evidence="ECO:0007829|PDB:1XVY"
FT TURN 235..239
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 241..243
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 250..252
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 254..262
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 268..279
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 281..289
FT /evidence="ECO:0007829|PDB:1XVY"
FT STRAND 290..292
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 310..313
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 320..322
FT /evidence="ECO:0007829|PDB:1XVY"
FT HELIX 325..334
FT /evidence="ECO:0007829|PDB:1XVY"
SQ SEQUENCE 338 AA; 36157 MW; DD5FAA452301A716 CRC64;
MKLRISSLGP VALLASSMML AFGAQAASAD QGIVIYNAQH ENLVKSWVDG FTKDTGIKVT
LRNGGDSELG NQLVQEGSAS PADVFLTENS PAMVLVDNAK LFAPLDAATL AQVEPQYRPS
HGRWIGIAAR STVFVYNPAK LSDAQLPKSL LDLAKPEWKG RWAASPSGAD FQAIVSALLE
LKGEKATLAW LKAMKTNFTA YKGNSTVMKA VNAGQVDSGV IYHYYPFVDG AKTGENSNNI
KLYYFKHQDP GAFVSISGGG VLASSKHQQQ AQAFIKWITG KQGQEILRTN NAFEYAVGVG
AASNPKLVPL KDLDAPKVDA AQLNSKKVVE LMTEAGLL
