FBPB2_HAEIN
ID FBPB2_HAEIN Reviewed; 506 AA.
AC P71338; Q53440;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Fe(3+)-transport system permease protein FbpB 2;
DE AltName: Full=Iron(III)-transport system permease protein FbpB 2;
GN Name=fbpB2; Synonyms=hitB; OrderedLocusNames=HI_0098;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NTHi TN106;
RX PubMed=7927717; DOI=10.1128/iai.62.10.4515-4525.1994;
RA Sanders J.D., Cope L.D., Hansen E.J.;
RT "Identification of a locus involved in the utilization of iron by
RT Haemophilus influenzae.";
RL Infect. Immun. 62:4515-4525(1994).
CC -!- FUNCTION: Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1)
CC involved in Fe(3+) ions import. Probably responsible for the
CC translocation of the substrate across the membrane (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FbpC),
CC two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FbpB subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC21774.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L42023; AAC21774.1; ALT_INIT; Genomic_DNA.
DR EMBL; S72674; AAB32111.1; -; Genomic_DNA.
DR PIR; T10887; D64048.
DR RefSeq; NP_438272.2; NC_000907.1.
DR AlphaFoldDB; P71338; -.
DR SMR; P71338; -.
DR STRING; 71421.HI_0098; -.
DR TCDB; 3.A.1.10.3; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; AAC21774; AAC21774; HI_0098.
DR KEGG; hin:HI_0098; -.
DR PATRIC; fig|71421.8.peg.101; -.
DR eggNOG; COG1178; Bacteria.
DR HOGENOM; CLU_021838_0_0_6; -.
DR PhylomeDB; P71338; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 2.
DR Gene3D; 1.10.3720.10; -; 2.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 2.
DR SUPFAM; SSF161098; SSF161098; 2.
DR PROSITE; PS50928; ABC_TM1; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..506
FT /note="Fe(3+)-transport system permease protein FbpB 2"
FT /id="PRO_0000060018"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 52..233
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 310..500
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT VARIANT 72
FT /note="F -> L (in strain: TN106)"
FT VARIANT 104
FT /note="G -> C (in strain: TN106)"
FT VARIANT 116
FT /note="V -> G (in strain: TN106)"
FT VARIANT 167
FT /note="S -> F (in strain: TN106)"
FT VARIANT 252
FT /note="T -> M (in strain: TN106)"
SQ SEQUENCE 506 AA; 56547 MW; ADA28861C1481A1D CRC64;
MPRRPPFWLT LLIILIGLPL CLPFLYVILR ATEVGLTRSV ELLFRPRMAE LLSNTMLLMV
CVTIGAISLG TFCAFLLERY RFFGKAFFEV AMTLPLCIPA FVSGFTWISL TFRVEVFWGT
IGIMTLSSFP LAYLPVSAIL KRLDRSLEEV SLSLGKSPVY TFWYAISPQL KPAIGSSILL
IALHMLVEFG AVSILNYQTF TTAIFQEYEM SFNNSTAALL SAVLMAICIL IVFGEIFFRG
KQTLYHSGKG VTRPYLVKTL SFGKQCLTFG FFSSIFILSI GVPVIMLIYW LIVGTSLESA
GDFSEFLSAF SNSFIISGLG ALLTVMCALP LVWAAVRYRS YLTIWIDRLP YLLHAVPGLV
IALSLVYFSI HYANDLYQTF FVIIIAYFML YLPMAQTTLR ASLEQLSDQI EKVGQSLGRN
PFYIFRTLTL PAILPGVAAA FALVFLNLMK ELTATLLLTS NDIKTLSIAV WEHTSDAQYA
AATPYALMLV LFSGIPVFLL KKYAFK
