FBPC2_HAEIN
ID FBPC2_HAEIN Reviewed; 356 AA.
AC P44513; Q53441;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Fe(3+) ions import ATP-binding protein FbpC 2 {ECO:0000255|HAMAP-Rule:MF_01706};
DE EC=7.2.2.7 {ECO:0000255|HAMAP-Rule:MF_01706};
GN Name=fbpC2 {ECO:0000255|HAMAP-Rule:MF_01706}; Synonyms=hitC;
GN OrderedLocusNames=HI_0099;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NTHi TN106;
RX PubMed=7927717; DOI=10.1128/iai.62.10.4515-4525.1994;
RA Sanders J.D., Cope L.D., Hansen E.J.;
RT "Identification of a locus involved in the utilization of iron by
RT Haemophilus influenzae.";
RL Infect. Immun. 62:4515-4525(1994).
RN [3]
RP CHARACTERIZATION.
RC STRAIN=DL63 / Serotype B;
RX PubMed=7559648; DOI=10.1074/jbc.270.42.25142;
RA Adhikari P., Kirby S.D., Nowalk A.J., Veraldi K.L., Schryvers A.B.,
RA Mietzner T.A.;
RT "Biochemical characterization of a Haemophilus influenzae periplasmic iron
RT transport operon.";
RL J. Biol. Chem. 270:25142-25149(1995).
CC -!- FUNCTION: Part of the ABC transporter complex FbpABC involved in Fe(3+)
CC ions import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01706}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate;
CC Xref=Rhea:RHEA:12332, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29034, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.7; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01706};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FbpC),
CC two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).
CC {ECO:0000255|HAMAP-Rule:MF_01706}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01706}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01706}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Fe(3+) ion
CC importer (TC 3.A.1.10) family. {ECO:0000255|HAMAP-Rule:MF_01706}.
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DR EMBL; L42023; AAC21775.1; -; Genomic_DNA.
DR EMBL; S72674; AAB32112.1; -; Genomic_DNA.
DR PIR; E64048; E64048.
DR PIR; T10888; T10888.
DR RefSeq; NP_438273.1; NC_000907.1.
DR RefSeq; WP_005693820.1; NC_000907.1.
DR AlphaFoldDB; P44513; -.
DR SMR; P44513; -.
DR STRING; 71421.HI_0099; -.
DR TCDB; 3.A.1.10.3; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; AAC21775; AAC21775; HI_0099.
DR KEGG; hin:HI_0099; -.
DR PATRIC; fig|71421.8.peg.102; -.
DR eggNOG; COG3842; Bacteria.
DR HOGENOM; CLU_000604_1_1_6; -.
DR PhylomeDB; P44513; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0015408; F:ABC-type ferric iron transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd03259; ABC_Carb_Solutes_like; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015853; ABC_transpr_FbpC.
DR InterPro; IPR030287; FbpC.
DR InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24220:SF675; PTHR24220:SF675; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF50331; SSF50331; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51242; FBPC; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Iron;
KW Iron transport; Membrane; Nucleotide-binding; Reference proteome;
KW Translocase; Transport.
FT CHAIN 1..356
FT /note="Fe(3+) ions import ATP-binding protein FbpC 2"
FT /id="PRO_0000092353"
FT DOMAIN 12..246
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
FT BINDING 44..51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
FT VARIANT 45
FT /note="S -> A (in strain: NTHi TN106)"
FT VARIANT 97
FT /note="V -> I (in strain: NTHi TN106)"
FT VARIANT 209
FT /note="S -> A (in strain: NTHi TN106)"
FT VARIANT 350
FT /note="R -> K (in strain: NTHi TN106)"
FT VARIANT 356
FT /note="S -> A (in strain: NTHi TN106)"
SQ SEQUENCE 356 AA; 40360 MW; 78F862F359760813 CRC64;
MRLNKMINNP LLTVKNLNKF FNEQQVLHDI SFSLQRGEIL FLLGSSGCGK TTLLRAIAGF
EQPSNGEIWL KERLIFGENF NLPTQQRHLG YVVQEGVLFP HLNVYRNIAY GLGNGKGKNS
EEKTRIEQIM QLTGIFELAD RFPHQLSGGQ QQRVALARAL APNPELILLD EPFSALDEHL
RQQIRQEMLQ ALRQSGASAI FVTHDRDESL RYADKIAIIQ QGKILQIDTP RTLYWSPNHL
ETAKFMGESI VLPANLLDEN TAQCQLGNIP IKNKSISQNQ GRILLRPEQF SLFKTSENPT
ALFNGQIKQI EFKGKITSIQ IEINGYAIWI ENVISPDLSI GDNLPVYLHR KGLFYS
