FBPC_BRUME
ID FBPC_BRUME Reviewed; 353 AA.
AC Q8YCG3;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Fe(3+) ions import ATP-binding protein FbpC {ECO:0000255|HAMAP-Rule:MF_01706};
DE EC=7.2.2.7 {ECO:0000255|HAMAP-Rule:MF_01706};
GN Name=fbpC {ECO:0000255|HAMAP-Rule:MF_01706}; OrderedLocusNames=BMEII0567;
OS Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=224914;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / NCTC 10094;
RX PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA Haselkorn R., Kyrpides N.C., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen Brucella
RT melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC -!- FUNCTION: Part of the ABC transporter complex FbpABC involved in Fe(3+)
CC ions import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01706}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate;
CC Xref=Rhea:RHEA:12332, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29034, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.7; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01706};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FbpC),
CC two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).
CC {ECO:0000255|HAMAP-Rule:MF_01706}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01706}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01706}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Fe(3+) ion
CC importer (TC 3.A.1.10) family. {ECO:0000255|HAMAP-Rule:MF_01706}.
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DR EMBL; AE008918; AAL53809.1; -; Genomic_DNA.
DR PIR; AF3580; AF3580.
DR RefSeq; WP_004682020.1; NZ_GG703779.1.
DR AlphaFoldDB; Q8YCG3; -.
DR SMR; Q8YCG3; -.
DR STRING; 224914.BMEII0567; -.
DR EnsemblBacteria; AAL53809; AAL53809; BMEII0567.
DR GeneID; 29595967; -.
DR KEGG; bme:BMEII0567; -.
DR PATRIC; fig|224914.52.peg.2808; -.
DR eggNOG; COG3842; Bacteria.
DR OMA; RDRQFLG; -.
DR PhylomeDB; Q8YCG3; -.
DR Proteomes; UP000000419; Chromosome II.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0015408; F:ABC-type ferric iron transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013611; Transp-assoc_OB_typ2.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF08402; TOBE_2; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF50331; SSF50331; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51242; FBPC; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Iron;
KW Iron transport; Membrane; Nucleotide-binding; Translocase; Transport.
FT CHAIN 1..353
FT /note="Fe(3+) ions import ATP-binding protein FbpC"
FT /id="PRO_0000092345"
FT DOMAIN 9..239
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
FT BINDING 41..48
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
SQ SEQUENCE 353 AA; 37919 MW; EFE93F7E2041A4AC CRC64;
MTAIRPGSVT FENVTKKFGN FTALPNLSLT VEPGTLVTLL GLSGCGKTTT LRLLAGLEHP
TSGRILIGGK DVTNLPANER DVSMVFQSYA LFPHMTSLEN VAYGLESSGF KKNEARERAE
EGLKLVGLGG MGHRLPAELS GGQQQRVAVA RALVLEPQVL LLDEPLSNLD ARLRRRVRTE
IRELQQRLGF TAVYVTHDQD EALAVSDTII VMKEGGIAQK GSPRDLYEAP ASAFIADFMG
EANVVPCEVI SAENGEAVIR VAGLTHRVPA RNAQPGPAQL AIRPNAVTLQ PQAGGGFSGT
VAHSAYLGDH IEYEIETEHG KLFIVDPAVE QSLPLQTDVS IQFKTRGLAI INQ
