FBPC_ECOLI
ID FBPC_ECOLI Reviewed; 348 AA.
AC P37009; P77157;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 3.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Fe(3+) ions import ATP-binding protein FbpC {ECO:0000255|HAMAP-Rule:MF_01706};
DE EC=7.2.2.7 {ECO:0000255|HAMAP-Rule:MF_01706};
GN Name=fbpC {ECO:0000255|HAMAP-Rule:MF_01706}; Synonyms=afuC, yagC;
GN OrderedLocusNames=b0262, JW0254;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T.,
RA Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S.,
RA Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.;
RT "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0
RT - 6.0 min (189,987 - 281,416bp) region.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP 147-148.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220.
RX PubMed=8113168; DOI=10.1128/jb.176.5.1297-1302.1994;
RA Volkert M.R., Loewen P.C., Switala J., Crowley D., Conley M.;
RT "The delta (argF-lacZ)205(U169) deletion greatly enhances resistance to
RT hydrogen peroxide in stationary-phase Escherichia coli.";
RL J. Bacteriol. 176:1297-1302(1994).
CC -!- FUNCTION: Part of the ABC transporter complex FbpABC involved in Fe(3+)
CC ions import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01706}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate;
CC Xref=Rhea:RHEA:12332, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29034, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.7; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01706};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FbpC),
CC two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).
CC {ECO:0000255|HAMAP-Rule:MF_01706}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01706}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01706}.
CC -!- MISCELLANEOUS: In E.coli, the afu system seems to have been deleted by
CC an insertion sequence. AfuA is totally lost, afuB is partially present
CC and afuC is totally conserved.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Fe(3+) ion
CC importer (TC 3.A.1.10) family. {ECO:0000255|HAMAP-Rule:MF_01706}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB08683.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=L20943; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U70214; AAB08683.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC73365.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA77930.2; -; Genomic_DNA.
DR EMBL; L20943; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR RefSeq; NP_414796.2; NC_000913.3.
DR RefSeq; WP_000192349.1; NZ_LN832404.1.
DR AlphaFoldDB; P37009; -.
DR SMR; P37009; -.
DR BioGRID; 4262792; 86.
DR BioGRID; 851989; 2.
DR DIP; DIP-9064N; -.
DR IntAct; P37009; 7.
DR STRING; 511145.b0262; -.
DR PaxDb; P37009; -.
DR PRIDE; P37009; -.
DR EnsemblBacteria; AAC73365; AAC73365; b0262.
DR EnsemblBacteria; BAA77930; BAA77930; BAA77930.
DR GeneID; 61125061; -.
DR GeneID; 947676; -.
DR KEGG; ecj:JW0254; -.
DR KEGG; eco:b0262; -.
DR PATRIC; fig|1411691.4.peg.2019; -.
DR EchoBASE; EB2244; -.
DR eggNOG; COG3842; Bacteria.
DR HOGENOM; CLU_000604_1_1_6; -.
DR InParanoid; P37009; -.
DR OMA; HEIVCVL; -.
DR PhylomeDB; P37009; -.
DR BioCyc; EcoCyc:YAGC-MON; -.
DR PRO; PR:P37009; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015408; F:ABC-type ferric iron transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR030287; FbpC.
DR InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013611; Transp-assoc_OB_typ2.
DR PANTHER; PTHR24220:SF675; PTHR24220:SF675; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF08402; TOBE_2; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF50331; SSF50331; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51242; FBPC; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Iron;
KW Iron transport; Membrane; Nucleotide-binding; Reference proteome;
KW Translocase; Transport.
FT CHAIN 1..348
FT /note="Fe(3+) ions import ATP-binding protein FbpC"
FT /id="PRO_0000092347"
FT DOMAIN 7..237
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
FT BINDING 39..46
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
SQ SEQUENCE 348 AA; 39059 MW; D4AD33754217DA1A CRC64;
MTQKNFVELR NVTKRFGSNT VIDNINLTIP QGQMVTLLGP SGCGKTTILR LVAGLEKPSE
GQIFIDGEDV THRSIQQRDI CMVFQSYALF PHMSLGENVG YGLKMLGVPR AELKARVKEA
LAMVDLEGFE DRFVDQISGG QQQRVALARA LILKPKVLLF DEPLSNLDAN LRRSMRDKIR
ELQKQFDITS LYVTHDQSEA FAVSDTVLVM NKGHIMQIGS PQDLYRQPAS RFMASFMGDA
NLFPATFSDG YVDIYGYHLP RPLHFGTQGE GMVGVRPEAI TLSDRGEESQ RCVIRHVAYM
GPQYEVTVEW HGQEILLQVN ATRLQPDVGE QYYLEIHPYG MFVLADAA
