FBPC_NEIG1
ID FBPC_NEIG1 Reviewed; 352 AA.
AC Q5FA19;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Fe(3+) ions import ATP-binding protein FbpC {ECO:0000255|HAMAP-Rule:MF_01706};
DE EC=7.2.2.7 {ECO:0000255|HAMAP-Rule:MF_01706};
GN Name=fbpC {ECO:0000255|HAMAP-Rule:MF_01706}; OrderedLocusNames=NGO0215;
OS Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=242231;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700825 / FA 1090;
RA Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F.,
RA Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C.,
RA Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H., Qi S.,
RA Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.;
RT "The complete genome sequence of Neisseria gonorrhoeae.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ABC transporter complex FbpABC involved in Fe(3+)
CC ions import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01706}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate;
CC Xref=Rhea:RHEA:12332, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29034, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.7; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01706};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FbpC),
CC two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).
CC {ECO:0000255|HAMAP-Rule:MF_01706}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01706}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01706}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Fe(3+) ion
CC importer (TC 3.A.1.10) family. {ECO:0000255|HAMAP-Rule:MF_01706}.
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DR EMBL; AE004969; AAW88968.1; -; Genomic_DNA.
DR RefSeq; WP_003687540.1; NC_002946.2.
DR RefSeq; YP_207380.1; NC_002946.2.
DR PDB; 3FVQ; X-ray; 1.90 A; A/B=1-352.
DR PDBsum; 3FVQ; -.
DR AlphaFoldDB; Q5FA19; -.
DR SMR; Q5FA19; -.
DR STRING; 242231.NGO_0215; -.
DR PRIDE; Q5FA19; -.
DR EnsemblBacteria; AAW88968; AAW88968; NGO_0215.
DR GeneID; 66752546; -.
DR KEGG; ngo:NGO_0215; -.
DR PATRIC; fig|242231.10.peg.267; -.
DR HOGENOM; CLU_000604_1_1_4; -.
DR OMA; RDRQFLG; -.
DR EvolutionaryTrace; Q5FA19; -.
DR Proteomes; UP000000535; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015408; F:ABC-type ferric iron transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR CDD; cd03259; ABC_Carb_Solutes_like; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015853; ABC_transpr_FbpC.
DR InterPro; IPR041230; FbpC_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17845; FbpC_C_terminal; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51242; FBPC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Cell inner membrane; Cell membrane;
KW Ion transport; Iron; Iron transport; Membrane; Nucleotide-binding;
KW Reference proteome; Translocase; Transport.
FT CHAIN 1..352
FT /note="Fe(3+) ions import ATP-binding protein FbpC"
FT /id="PRO_0000272040"
FT DOMAIN 5..239
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
FT STRAND 5..14
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 17..27
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 32..38
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 43..50
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 57..63
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 66..72
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 77..79
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 83..85
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 97..102
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 113..125
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 129..131
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 136..138
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 141..153
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 158..164
FT /evidence="ECO:0007829|PDB:3FVQ"
FT TURN 165..168
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 171..187
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 191..195
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 199..205
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 207..213
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 216..221
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 223..228
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 233..239
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 243..249
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 251..257
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 260..265
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 273..278
FT /evidence="ECO:0007829|PDB:3FVQ"
FT HELIX 280..282
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 283..287
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 292..304
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 306..315
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 318..326
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 335..340
FT /evidence="ECO:0007829|PDB:3FVQ"
FT STRAND 344..348
FT /evidence="ECO:0007829|PDB:3FVQ"
SQ SEQUENCE 352 AA; 37902 MW; 2EB9713C445BA3C0 CRC64;
MTAALHIGHL SKSFQNTPVL NDISLSLDPG EILFIIGASG CGKTTLLRCL AGFEQPDSGE
ISLSGKTIFS KNTNLPVRER RLGYLVQEGV LFPHLTVYRN IAYGLGNGKG RTAQERQRIE
AMLELTGISE LAGRYPHELS GGQQQRVALA RALAPDPELI LLDEPFSALD EQLRRQIRED
MIAALRANGK SAVFVSHDRE EALQYADRIA VMKQGRILQT ASPHELYRQP ADLDAALFIG
EGIVFPAALN ADGTADCRLG RLPVQSGAPA GTRGTLLIRP EQFSLHPHSA PAASIHAVVL
KTTPKARHTE ISLRAGQTVL TLNLPSAPTL SDGISAVLHL DGPALFFPGN TL
