ID   FBPC_VIBCH              Reviewed;         351 AA.
AC   Q9KLQ5;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Fe(3+) ions import ATP-binding protein FbpC {ECO:0000255|HAMAP-Rule:MF_01706};
DE            EC=7.2.2.7 {ECO:0000255|HAMAP-Rule:MF_01706};
GN   Name=fbpC {ECO:0000255|HAMAP-Rule:MF_01706}; OrderedLocusNames=VC_A0687;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Part of the ABC transporter complex FbpABC involved in Fe(3+)
CC       ions import. Responsible for energy coupling to the transport system.
CC       {ECO:0000255|HAMAP-Rule:MF_01706}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate;
CC         Xref=Rhea:RHEA:12332, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29034, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:456216; EC=7.2.2.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01706};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FbpC),
CC       two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).
CC       {ECO:0000255|HAMAP-Rule:MF_01706}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01706}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01706}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Fe(3+) ion
CC       importer (TC 3.A.1.10) family. {ECO:0000255|HAMAP-Rule:MF_01706}.
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DR   EMBL; AE003853; AAF96587.1; -; Genomic_DNA.
DR   PIR; A82429; A82429.
DR   RefSeq; NP_233075.1; NC_002506.1.
DR   RefSeq; WP_000414891.1; NZ_LT906615.1.
DR   AlphaFoldDB; Q9KLQ5; -.
DR   SMR; Q9KLQ5; -.
DR   STRING; 243277.VC_A0687; -.
DR   TCDB; 3.A.1.20.2; the atp-binding cassette (abc) superfamily.
DR   DNASU; 2612164; -.
DR   EnsemblBacteria; AAF96587; AAF96587; VC_A0687.
DR   GeneID; 57742078; -.
DR   KEGG; vch:VC_A0687; -.
DR   PATRIC; fig|243277.26.peg.3312; -.
DR   eggNOG; COG3842; Bacteria.
DR   HOGENOM; CLU_000604_1_1_6; -.
DR   OMA; RDRQFLG; -.
DR   BioCyc; VCHO:VCA0687-MON; -.
DR   Proteomes; UP000000584; Chromosome 2.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015408; F:ABC-type ferric iron transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR030287; FbpC.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013611; Transp-assoc_OB_typ2.
DR   PANTHER; PTHR24220:SF675; PTHR24220:SF675; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF08402; TOBE_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51242; FBPC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Iron;
KW   Iron transport; Membrane; Nucleotide-binding; Reference proteome;
KW   Translocase; Transport.
FT   CHAIN           1..351
FT                   /note="Fe(3+) ions import ATP-binding protein FbpC"
FT                   /id="PRO_0000092367"
FT   DOMAIN          7..237
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
SQ   SEQUENCE   351 AA;  39575 MW;  0A545FDC98EC8FC3 CRC64;
     MEKQNFVVLK NICKRFGSNT VIGNLDLEIK KGSLVTLLGP SGCGKTTVLR LVAGLEKPTS
     GQIFIDGEDV TERSIQQRDI CMVFQSYALF PHMSLYENVA YGLKMLKLPS EEVRQRVDEA
     LKIVDLEGMG ERYVDQISGG QQQRVALARA LVLKPKVLLF DEPLSNLDAN LRRSMRETIR
     ELQQRFDITS LYVTHDQAEA FAVSDTVIVM KQGDIMQIGT PQELYKAPKS MFMANFMGEA
     NMFQGHFDGQ QIHINGYAID ADLEVTRDKP NGEYQIGVRP EAITLHTQGS ESQACQILKS
     AYMGSMYEVT VKWHDQELLL QLNSAQFNHT LTQHAYVVFN PRGLFLLPYA E