ID   AIM46_YEAST             Reviewed;         310 AA.
AC   P38885; D3DLE7;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Altered inheritance of mitochondria protein 46, mitochondrial;
DE   AltName: Full=Found in mitochondrial proteome protein 34;
DE   Flags: Precursor;
GN   Name=AIM46; Synonyms=FMP34; OrderedLocusNames=YHR199C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8091229; DOI=10.1126/science.8091229;
RA   Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA   Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA   Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA   Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA   St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA   Waterston R., Wilson R., Vaudin M.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   VIII.";
RL   Science 265:2077-2082(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA   Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA   Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA   Troyanskaya O.G., Caudy A.A.;
RT   "Computationally driven, quantitative experiments discover genes required
RT   for mitochondrial biogenesis.";
RL   PLoS Genet. 5:E1000407-E1000407(2009).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
CC   -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC       {ECO:0000269|PubMed:19300474}.
CC   -!- MISCELLANEOUS: Present with 1350 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the AIM18/AIM46 family. {ECO:0000305}.
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DR   EMBL; U00030; AAB68371.1; -; Genomic_DNA.
DR   EMBL; BK006934; DAA06891.1; -; Genomic_DNA.
DR   PIR; S46694; S46694.
DR   RefSeq; NP_012069.3; NM_001179330.3.
DR   AlphaFoldDB; P38885; -.
DR   SMR; P38885; -.
DR   BioGRID; 36633; 132.
DR   DIP; DIP-4350N; -.
DR   IntAct; P38885; 22.
DR   iPTMnet; P38885; -.
DR   MaxQB; P38885; -.
DR   PaxDb; P38885; -.
DR   PRIDE; P38885; -.
DR   EnsemblFungi; YHR199C_mRNA; YHR199C; YHR199C.
DR   GeneID; 856606; -.
DR   KEGG; sce:YHR199C; -.
DR   SGD; S000001242; AIM46.
DR   VEuPathDB; FungiDB:YHR199C; -.
DR   eggNOG; ENOG502RGD3; Eukaryota.
DR   GeneTree; ENSGT00940000176696; -.
DR   HOGENOM; CLU_038840_0_1_1; -.
DR   InParanoid; P38885; -.
DR   OMA; PENSHQD; -.
DR   BioCyc; YEAST:G3O-31227-MON; -.
DR   ChiTaRS; AIM46; yeast.
DR   PRO; PR:P38885; -.
DR   Proteomes; UP000002311; Chromosome VIII.
DR   RNAct; P38885; protein.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0016872; F:intramolecular lyase activity; IEA:InterPro.
DR   Gene3D; 3.50.70.10; -; 1.
DR   InterPro; IPR016087; Chalcone_isomerase.
DR   InterPro; IPR016088; Chalcone_isomerase_3-sand.
DR   InterPro; IPR036298; Chalcone_isomerase_sf.
DR   Pfam; PF16035; Chalcone_2; 1.
DR   SUPFAM; SSF54626; SSF54626; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..20
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..310
FT                   /note="Altered inheritance of mitochondria protein 46,
FT                   mitochondrial"
FT                   /id="PRO_0000202940"
SQ   SEQUENCE   310 AA;  34113 MW;  4E063889E061EEB3 CRC64;
     MRLISKVLVK TNCLEVGMRR APQWYSHYST TAGNARVNKK GSKVVPVLTG LALASIFAKK
     WYDDSQIKKA DATSVAVDAS ISAFPKKMGP PQWPFSTQYE LIGKGVRCVS SITFKAYGLG
     IYVAAEDKHL VSEVLDSKFL SQAFIDTAAP PSPENSHQDN LRAALNDPAK APILINNLLD
     SGIRLMSKNT PIKAGSFKLL MDGTKKSVLK NPDSQSQDKD RLEAGFQELH DCFRSVKGLV
     ARDDDFFIEL NKDCSMNLSY YARKKDEFVI LGTVKEPLIG KLLFAHYLAA VDPPSPEARK
     EVIDALVSLS