FBRS_HUMAN
ID FBRS_HUMAN Reviewed; 460 AA.
AC Q9HAH7; B4DP86; Q96CI9; Q9H9X4;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Probable fibrosin-1;
GN Name=FBRS; Synonyms=FBS, FBS1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 84-460 (ISOFORM 1).
RC TISSUE=Embryo, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP CHARACTERIZATION OF 3'-UTR.
RC TISSUE=Placenta, and T-cell;
RX PubMed=9809749; DOI=10.1089/dna.1998.17.879;
RA Prakash S., Robbins P.W.;
RT "Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic
RT lymphokine.";
RL DNA Cell Biol. 17:879-884(1998).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-229 AND ARG-239, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-8, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2;
CC IsoId=Q9HAH7-2; Sequence=Displayed;
CC Name=1;
CC IsoId=Q9HAH7-1; Sequence=VSP_010991;
CC -!- CAUTION: Prakash et al. cloned a cDNA corresponding to the 3'UTR of the
CC last exon of the gene (PubMed:9809749). They have shown that a
CC synthetic peptide derived from this sequence could stimulate
CC fibroblasts growth in vitro, and that this protein could be a
CC fibrogenic lymphokine, that could stimulate several biological
CC activities related to scarring. It would be expressed in placenta,
CC skeletal muscle, pancreas, thymus, testis, and leukocytes. However, it
CC was not confirmed by in vivo data. {ECO:0000305|PubMed:9809749}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB13872.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB14094.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK021680; BAB13872.1; ALT_INIT; mRNA.
DR EMBL; AK022551; BAB14094.1; ALT_INIT; mRNA.
DR EMBL; AK298229; BAG60498.1; -; mRNA.
DR EMBL; AC093249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001098549.2; NM_001105079.2.
DR AlphaFoldDB; Q9HAH7; -.
DR BioGRID; 122132; 87.
DR DIP; DIP-61357N; -.
DR IntAct; Q9HAH7; 48.
DR MINT; Q9HAH7; -.
DR STRING; 9606.ENSP00000348489; -.
DR iPTMnet; Q9HAH7; -.
DR PhosphoSitePlus; Q9HAH7; -.
DR BioMuta; FBRS; -.
DR DMDM; 332278207; -.
DR EPD; Q9HAH7; -.
DR jPOST; Q9HAH7; -.
DR MassIVE; Q9HAH7; -.
DR MaxQB; Q9HAH7; -.
DR PaxDb; Q9HAH7; -.
DR PeptideAtlas; Q9HAH7; -.
DR PRIDE; Q9HAH7; -.
DR ProteomicsDB; 81404; -. [Q9HAH7-2]
DR ProteomicsDB; 81405; -. [Q9HAH7-1]
DR Antibodypedia; 43660; 73 antibodies from 16 providers.
DR DNASU; 64319; -.
DR Ensembl; ENST00000287468.5; ENSP00000287468.5; ENSG00000156860.16. [Q9HAH7-2]
DR GeneID; 64319; -.
DR KEGG; hsa:64319; -.
DR UCSC; uc002dzd.4; human. [Q9HAH7-2]
DR CTD; 64319; -.
DR DisGeNET; 64319; -.
DR GeneCards; FBRS; -.
DR HGNC; HGNC:20442; FBRS.
DR HPA; ENSG00000156860; Low tissue specificity.
DR MIM; 608601; gene.
DR neXtProt; NX_Q9HAH7; -.
DR OpenTargets; ENSG00000156860; -.
DR PharmGKB; PA162388128; -.
DR VEuPathDB; HostDB:ENSG00000156860; -.
DR eggNOG; ENOG502QT69; Eukaryota.
DR GeneTree; ENSGT00940000161032; -.
DR HOGENOM; CLU_049409_0_0_1; -.
DR InParanoid; Q9HAH7; -.
DR OMA; GTFNGNC; -.
DR OrthoDB; 229224at2759; -.
DR PathwayCommons; Q9HAH7; -.
DR SignaLink; Q9HAH7; -.
DR BioGRID-ORCS; 64319; 15 hits in 218 CRISPR screens.
DR ChiTaRS; FBRS; human.
DR GeneWiki; FBRS; -.
DR GenomeRNAi; 64319; -.
DR Pharos; Q9HAH7; Tbio.
DR PRO; PR:Q9HAH7; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9HAH7; protein.
DR Bgee; ENSG00000156860; Expressed in left testis and 199 other tissues.
DR ExpressionAtlas; Q9HAH7; baseline and differential.
DR Genevisible; Q9HAH7; HS.
DR InterPro; IPR023246; AUTS2.
DR PANTHER; PTHR14429; PTHR14429; 1.
DR Pfam; PF15336; Auts2; 1.
DR PRINTS; PR02044; FIBROSIN1LPF.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Methylation; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..460
FT /note="Probable fibrosin-1"
FT /id="PRO_0000087206"
FT REGION 40..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..453
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 229
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 239
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 281
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CROSSLNK 8
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 429..460
FT /note="PPGALLGAPPPLVPAPRPSSPPRGPGPARADR -> FCTFLQGCPSQQFPSW
FT LIKPSDWCCVPSLWPLCGERGLQGEEPGRDSQASPWEGGASRR (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_010991"
FT CONFLICT 168
FT /note="S -> G (in Ref. 1; BAG60498)"
FT /evidence="ECO:0000305"
FT CONFLICT 255
FT /note="V -> A (in Ref. 1; BAB13872)"
FT /evidence="ECO:0000305"
FT CONFLICT 283
FT /note="A -> V (in Ref. 1; BAG60498)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 460 AA; 48388 MW; B99B5624ACD7848B CRC64;
MFEKYPGKME GLFRHNPYTA FPPAVPGLPP GLPPAVSFGS LQGAFQPKST NPELPPRLGP
VPSGLSQKGT QIPDHFRPPL RKPGKWCAMH VRVAYMILRH QEKMKGDSHK LDFRNDLLPC
LPGPYGALPP GQELSHPASL FTATGAVHAA ANPFTAAPGA HGPFLSPSTH IDPFGRPTSF
ASLAALSNGA FGGLGSPTFN SGAVFAQKES PGAPPAFASP PDPWGRLHRS PLTFPAWVRP
PEAARTPGSD KERPVERREP SITKEEKDRD LPFSRPQLRV SPATPKARAG EEGPRPTKES
VRVKEERKEE AAAAAAAAAA AAAAAAAAAT GPQGLHLLFE RPRPPPFLGP SPPDRCAGFL
EPTWLAAPPR LARPPRFYEA GEELTGPGAV AAARLYGLEP AHPLLYSRLA PPPPPAAAPG
TPHLLSKTPP GALLGAPPPL VPAPRPSSPP RGPGPARADR
