FBRS_MOUSE
ID FBRS_MOUSE Reviewed; 466 AA.
AC Q8R089;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Probable fibrosin-1;
GN Name=Fbrs; Synonyms=Fbs, Fbs1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-466.
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-466.
RC TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP CHARACTERIZATION OF 3'-UTR.
RX PubMed=7892239; DOI=10.1073/pnas.92.6.2154;
RA Prakash S., Robbins P.W., Wyler D.J.;
RT "Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine,
RT fibrosin.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:2154-2158(1995).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-229, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- CAUTION: Prakash et al. cloned a partial cDNA corresponding to the
CC 3'UTR of the last exon of the gene (PubMed:7892239). They have shown
CC that a synthetic peptide derived from this sequence could stimulate
CC fibroblasts growth in vitro, and that this protein could be a
CC fibrogenic lymphokine, that could stimulate several biological
CC activities related to scarring. It would be expressed several cell
CC types including CD4+ lymphocytes and fibroblasts. However, it was not
CC confirmed by in vivo data. {ECO:0000305|PubMed:7892239}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27193.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AK037952; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AK037952; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AC136146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027193; AAH27193.1; ALT_INIT; mRNA.
DR EMBL; AK037952; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_034313.1; NM_010183.1.
DR AlphaFoldDB; Q8R089; -.
DR STRING; 10090.ENSMUSP00000043682; -.
DR iPTMnet; Q8R089; -.
DR PhosphoSitePlus; Q8R089; -.
DR jPOST; Q8R089; -.
DR MaxQB; Q8R089; -.
DR PaxDb; Q8R089; -.
DR PRIDE; Q8R089; -.
DR ProteomicsDB; 271878; -.
DR Antibodypedia; 43660; 73 antibodies from 16 providers.
DR Ensembl; ENSMUST00000048896; ENSMUSP00000043682; ENSMUSG00000042423.
DR GeneID; 14123; -.
DR KEGG; mmu:14123; -.
DR UCSC; uc009jvs.2; mouse.
DR CTD; 64319; -.
DR MGI; MGI:104648; Fbrs.
DR VEuPathDB; HostDB:ENSMUSG00000042423; -.
DR eggNOG; ENOG502QT69; Eukaryota.
DR GeneTree; ENSGT00940000161032; -.
DR HOGENOM; CLU_049409_0_0_1; -.
DR InParanoid; Q8R089; -.
DR PhylomeDB; Q8R089; -.
DR TreeFam; TF331929; -.
DR BioGRID-ORCS; 14123; 6 hits in 71 CRISPR screens.
DR ChiTaRS; Fbrs; mouse.
DR PRO; PR:Q8R089; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8R089; protein.
DR Bgee; ENSMUSG00000042423; Expressed in granulocyte and 59 other tissues.
DR ExpressionAtlas; Q8R089; baseline and differential.
DR Genevisible; Q8R089; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0008083; F:growth factor activity; IDA:MGI.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IDA:MGI.
DR InterPro; IPR023246; AUTS2.
DR PANTHER; PTHR14429; PTHR14429; 1.
DR Pfam; PF15336; Auts2; 1.
DR PRINTS; PR02044; FIBROSIN1LPF.
PE 1: Evidence at protein level;
KW Isopeptide bond; Methylation; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..466
FT /note="Probable fibrosin-1"
FT /id="PRO_0000087207"
FT REGION 236..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..426
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..459
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 229
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 239
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9HAH7"
FT MOD_RES 281
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HAH7"
FT CROSSLNK 8
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9HAH7"
FT CONFLICT 283
FT /note="A -> T (in Ref. 3; AK037952)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 466 AA; 49038 MW; 9852DF3F13B97FAE CRC64;
MFEKYPGKME GLFRHNPYMA FPPAVPGLPP GLPPAVSFGS LQGAFQPKNT NPELPPRLGP
VLSGLPQKGT QIPDHFRPPL RKPGKWCAMH VRVAYMILRH QEKMKGDSHK LDFRNDLLPC
LPGPYGALPP GQELSHPASL FTATGAVHAA ANPFTTAPGA HGPFLSPSTH IDPFGRPTSF
ASLAALSNGA FGGLGSPTFN SSAVFAQKES PGAPPAFASP PDPWGRLHRS PLAFPAWVRP
PETARTPGSD KERPMERREP SVTKEEKDRD LPFSRPQLRV SPATPKARAG EEGARPAKES
VRVKEERKEE AAAAAAAAAA AAAAAAAAAA AAAATTGPQG LHLLLERPRP PPFLGPSLPE
RCAGFPEPTW LAGPPRLARP PRFYEAGEEL TGPGAMAAAR LYSLDPAHPL LYSRLAPPPP
PTATPGTPHL LSKTPPGALL GAPPPLVPAP RPSSPPRAPG PARADR
