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FBSB_SYNY3
ID   FBSB_SYNY3              Reviewed;         345 AA.
AC   P73922;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase;
DE            Short=FBPase class 2/SBPase;
DE            EC=3.1.3.11;
DE            EC=3.1.3.37;
GN   OrderedLocusNames=slr2094;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru
CC       1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6-
CC       phosphate and sedoheptulose 7-phosphate, respectively. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-
CC         phosphate + phosphate; Xref=Rhea:RHEA:17461, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57483, ChEBI:CHEBI:58335; EC=3.1.3.37;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- PATHWAY: Carbohydrate biosynthesis; Calvin cycle.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FBPase class 2 family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA17988.1; -; Genomic_DNA.
DR   PIR; S75126; S75126.
DR   PDB; 3ROJ; X-ray; 2.30 A; A/B/C/D=2-345.
DR   PDB; 3RPL; X-ray; 2.40 A; A/B/C/D=2-345.
DR   PDBsum; 3ROJ; -.
DR   PDBsum; 3RPL; -.
DR   AlphaFoldDB; P73922; -.
DR   SMR; P73922; -.
DR   IntAct; P73922; 1.
DR   MINT; P73922; -.
DR   STRING; 1148.1653071; -.
DR   PaxDb; P73922; -.
DR   PRIDE; P73922; -.
DR   EnsemblBacteria; BAA17988; BAA17988; BAA17988.
DR   KEGG; syn:slr2094; -.
DR   eggNOG; COG1494; Bacteria.
DR   InParanoid; P73922; -.
DR   OMA; AVFYMDK; -.
DR   PhylomeDB; P73922; -.
DR   BioCyc; MetaCyc:FBPSBP-MON; -.
DR   BRENDA; 3.1.3.11; 382.
DR   BRENDA; 3.1.3.37; 382.
DR   UniPathway; UPA00116; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0050278; F:sedoheptulose-bisphosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030388; P:fructose 1,6-bisphosphate metabolic process; IBA:GO_Central.
DR   GO; GO:0006094; P:gluconeogenesis; IBA:GO_Central.
DR   GO; GO:0006071; P:glycerol metabolic process; IEA:InterPro.
DR   GO; GO:0019253; P:reductive pentose-phosphate cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd01516; FBPase_glpX; 1.
DR   InterPro; IPR004464; FBPase_class-2/SBPase.
DR   PANTHER; PTHR30447; PTHR30447; 1.
DR   Pfam; PF03320; FBPase_glpX; 1.
DR   PIRSF; PIRSF004532; GlpX; 1.
DR   TIGRFAMs; TIGR00330; glpX; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Calvin cycle; Carbohydrate metabolism; Hydrolase; Manganese;
KW   Metal-binding; Reference proteome.
FT   CHAIN           1..345
FT                   /note="D-fructose 1,6-bisphosphatase class 2/sedoheptulose
FT                   1,7-bisphosphatase"
FT                   /id="PRO_0000342735"
FT   BINDING         33
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         57
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         97
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         100..102
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         100
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         131
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         176..178
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         198..200
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         225
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   HELIX           5..21
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   TURN            22..25
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           29..44
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          50..57
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   TURN            60..62
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          64..66
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          71..73
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           74..76
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           80..83
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           87..89
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          90..100
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           102..107
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          113..120
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          131..137
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           139..141
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   TURN            142..144
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           151..161
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           166..168
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          170..174
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           177..179
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           180..189
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          192..198
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           200..206
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          216..222
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           223..236
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          239..245
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   TURN            248..250
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           260..269
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          278..280
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   HELIX           281..284
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          287..298
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          301..303
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          307..309
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          312..321
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   TURN            322..325
FT                   /evidence="ECO:0007829|PDB:3ROJ"
FT   STRAND          326..335
FT                   /evidence="ECO:0007829|PDB:3ROJ"
SQ   SEQUENCE   345 AA;  37075 MW;  A6DA0D2E16724179 CRC64;
     MDSTLGLEII EVVEQAAIAS AKWMGKGEKN TADQVAVEAM RERMNKIHMR GRIVIGEGER
     DDAPMLYIGE EVGICTREDA KSFCNPDELV EIDIAVDPCE GTNLVAYGQN GSMAVLAISE
     KGGLFAAPDF YMKKLAAPPA AKGHVDIDKS ATENLKILSD CLNRSIEELV VVVMDRPRHK
     ELIQEIRNAG ARVRLISDGD VSAAISCAFS GTNIHALMGI GAAPEGVISA AAMRCLGGHF
     QGQLIYDPEV VKTGLIGESR EGNLERLASM GIKNPDQVYN CEELACGETV LFAACGITPG
     TLMEGVRFFH GGVRTQSLVI SSQSSTARFV DTVHMKESPK VIQLH
 
 
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