FBSL_HUMAN
ID FBSL_HUMAN Reviewed; 1045 AA.
AC Q9HCM7; Q86XQ1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 4.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Fibrosin-1-like protein;
DE AltName: Full=AUTS2-like protein;
DE AltName: Full=HBV X-transactivated gene 9 protein;
DE AltName: Full=HBV XAg-transactivated protein 9;
GN Name=FBRSL1; Synonyms=AUTS2L, KIAA1545, XTP9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-1045.
RC TISSUE=Brain;
RX PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:273-281(2000).
RN [4]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 379-1045.
RA Liu Y., Cheng J., Lu Y., Wang G., Zhang L., Chen J., Li L.;
RT "Cloning and identification of human gene 9 transactivated by hepatitis B
RT virus X antigen.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-989 AND THR-1010, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-937, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340; SER-790; SER-937;
RP SER-977 AND THR-1010, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-858, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- SIMILARITY: Belongs to the AUTS2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAW54843.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC079031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471218; EAW54843.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB046765; BAB13371.2; -; mRNA.
DR EMBL; AF490258; AAO85466.1; -; mRNA.
DR CCDS; CCDS45010.1; -.
DR RefSeq; NP_001136113.1; NM_001142641.1.
DR AlphaFoldDB; Q9HCM7; -.
DR BioGRID; 121699; 51.
DR IntAct; Q9HCM7; 38.
DR STRING; 9606.ENSP00000396160; -.
DR iPTMnet; Q9HCM7; -.
DR PhosphoSitePlus; Q9HCM7; -.
DR BioMuta; FBRSL1; -.
DR DMDM; 317373568; -.
DR EPD; Q9HCM7; -.
DR jPOST; Q9HCM7; -.
DR MassIVE; Q9HCM7; -.
DR MaxQB; Q9HCM7; -.
DR PaxDb; Q9HCM7; -.
DR PeptideAtlas; Q9HCM7; -.
DR PRIDE; Q9HCM7; -.
DR ProteomicsDB; 81767; -.
DR Antibodypedia; 56621; 67 antibodies from 17 providers.
DR DNASU; 57666; -.
DR Ensembl; ENST00000434748.2; ENSP00000396160.2; ENSG00000112787.14.
DR GeneID; 57666; -.
DR KEGG; hsa:57666; -.
DR UCSC; uc001ukf.4; human.
DR CTD; 57666; -.
DR DisGeNET; 57666; -.
DR GeneCards; FBRSL1; -.
DR HGNC; HGNC:29308; FBRSL1.
DR HPA; ENSG00000112787; Low tissue specificity.
DR neXtProt; NX_Q9HCM7; -.
DR OpenTargets; ENSG00000112787; -.
DR PharmGKB; PA164720011; -.
DR VEuPathDB; HostDB:ENSG00000112787; -.
DR eggNOG; ENOG502QSH4; Eukaryota.
DR GeneTree; ENSGT00940000160709; -.
DR HOGENOM; CLU_007298_1_0_1; -.
DR InParanoid; Q9HCM7; -.
DR OMA; MFDKYTP; -.
DR OrthoDB; 229224at2759; -.
DR PhylomeDB; Q9HCM7; -.
DR TreeFam; TF331929; -.
DR PathwayCommons; Q9HCM7; -.
DR SignaLink; Q9HCM7; -.
DR BioGRID-ORCS; 57666; 7 hits in 1073 CRISPR screens.
DR ChiTaRS; FBRSL1; human.
DR GenomeRNAi; 57666; -.
DR Pharos; Q9HCM7; Tdark.
DR PRO; PR:Q9HCM7; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9HCM7; protein.
DR Bgee; ENSG00000112787; Expressed in pancreatic ductal cell and 175 other tissues.
DR ExpressionAtlas; Q9HCM7; baseline and differential.
DR Genevisible; Q9HCM7; HS.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR023246; AUTS2.
DR PANTHER; PTHR14429; PTHR14429; 1.
DR Pfam; PF15336; Auts2; 1.
DR PRINTS; PR02044; FIBROSIN1LPF.
PE 1: Evidence at protein level;
KW Isopeptide bond; Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN 1..1045
FT /note="Fibrosin-1-like protein"
FT /id="PRO_0000321962"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..285
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..949
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1018
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 790
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 937
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 977
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 989
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 1010
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:23186163"
FT CROSSLNK 858
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 367
FT /note="L -> P (in dbSNP:rs879759065)"
FT /id="VAR_039390"
FT CONFLICT 836
FT /note="A -> V (in Ref. 3; BAB13371)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1045 AA; 110907 MW; 2339F7EC7A0E7899 CRC64;
MEAKVRPSRR SRAQRDRGRR REAARDARAQ SPSSGDEPEP SPGKENAGLR GAPPRGAAPA
PRTARPPRRR RRESSSQEEE VIDGFAIASF STLEALEKDM ALKPHERKEK WERRLIKKPR
ESETCPPAEP SENRRPLEAG SPGQDLEPAC DGARKVPLQP SKQMKVTVSK GGDRDSDDDS
VLEATSSRDP LSDSSAHAVS GRGYSCDSES GPDDKASVGS EKLFAPGTDK GPALEKSEAK
AGPVPKVSGL ERSRELSAES FLPTASPAPH AAPCPGPPPG SRANPLVKKE PPAPHRHTPQ
PPPPQPRGLL PTHVPASLGA FAGHSQAAAN GLHGLSRSSS APLGLGKHVS LSPHGPGPHL
STSHLALRSQ AQHQLHAAMF AAPPTLPPPP ALPASSLVLP GHPADHELLR QELNTRFLVQ
SAERPGASLG PGALLRAEFH QHQHTHQHTH QHTHQHQHTF APFPAGLPPT PPAAPPPFDK
YAPKLDSPYF RHSSVSFFPS FPPAIPGLPT LLPHPGPFGS LQGAFQPKVS DPYRAVVKVS
TCWEGPWQGR TLVPPGRPRG ARDSRSLQKT WVGVAPAPLS ASILSQKPGR WCAVHVQIAW
QIYRHQQKIK EMQLDPHKLE VGAKLDLFGR PPAPGVFAGF HYPQDLARPL FPSTGAAHPA
SNPFGPSAHP GSFLPTGPLT DPFSRPSTFG GLGSLSSHAF GGLGSHALAP GGSIFAPKEG
SSVHGLPSPH EAWNRLHRAP PSFPAPPPWP KSVDAERVSA LTNHDREPDN GKEEQERDLL
EKTRLLSRAS PATPAGHPVS GLLLRAQSEL GRSGAPAERE AEPRVKESRS PAKEEAAKMP
ARASPPHSKA APGDVKVKEE RGEDEASEPP AGGLHPAPLQ LGLGRERLGA PGFAWEPFRG
LELPRRAFPA AAPAPGSAAL LEPPERPYRD REPHGYSPER LRGELERARA PHLPPAAPAL
DGALLPSLGA LHFPRLSPAA LHNGLLARTP PAAAALGAPP PLVTAAGPPT PPGPPRSRTT
PLGGLGPGEA RDYSPSRNPP EVEAR
