ID   FBSP1_AEDAE             Reviewed;         258 AA.
AC   Q16XV7;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=F-box/SPRY domain-containing protein 1 {ECO:0000250|UniProtKB:Q9V6L9};
GN   Name=Fsn {ECO:0000250|UniProtKB:Q9V6L9}; ORFNames=AAEL008758;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Required in the presynaptic motoneuron to down-regulate the
CC       levels of wnd and restrain synaptic terminal growth at the
CC       neuromuscular junction (NMJ). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q9V6L9}.
CC   -!- SUBUNIT: Component of an E3 ubiquitin ligase complex composed of hiw
CC       and Fsn. {ECO:0000250|UniProtKB:Q9V6L9}.
CC   -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q9V6L9}.
CC   -!- SIMILARITY: Belongs to the FBXO45/Fsn family. {ECO:0000305}.
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DR   EMBL; CH477532; EAT39436.1; -; Genomic_DNA.
DR   RefSeq; XP_001659457.1; XM_001659407.1.
DR   AlphaFoldDB; Q16XV7; -.
DR   SMR; Q16XV7; -.
DR   STRING; 7159.AAEL008758-PA; -.
DR   GeneID; 5571026; -.
DR   KEGG; aag:5571026; -.
DR   VEuPathDB; VectorBase:AAEL008758; -.
DR   eggNOG; KOG3953; Eukaryota.
DR   HOGENOM; CLU_046756_1_0_1; -.
DR   InParanoid; Q16XV7; -.
DR   OMA; YHAWNPN; -.
DR   OrthoDB; 1027590at2759; -.
DR   PhylomeDB; Q16XV7; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
DR   GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd12907; SPRY_Fbox; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035784; SPRY_FBXO45.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   3: Inferred from homology;
KW   Neurogenesis; Reference proteome; Synapse; Ubl conjugation pathway.
FT   CHAIN           1..258
FT                   /note="F-box/SPRY domain-containing protein 1"
FT                   /id="PRO_0000383307"
FT   DOMAIN          6..54
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          64..256
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ   SEQUENCE   258 AA;  29206 MW;  0EFC2448E6762E05 CRC64;
     MDDDLTEYAP DIPDNVLELI FSYLKLQDLR NCSLVCKSWN RFLNDENNEV WRAQCMQKLS
     PDAFKTDLLS VVPTYKAKLR AFFHAWNPYD CSRHVYIKPN GFTLHRNPVA QSTDGSRGKI
     GFQHGRHAWE VRWEGPLGTV AVVGIATKDA AIQCHGYYAL LGADDQSWGW NLVDNLLLHN
     GDAHGIYPLL NNAPKYKVGE RIRVILDCDD NTLSFEKNYE FLGVAFTDLP DKVFYPTVAA
     VYGNTEISMV YLGPPLDG