FBSP1_BRUMA
ID FBSP1_BRUMA Reviewed; 299 AA.
AC A8QGZ7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=F-box/SPRY domain-containing protein 1;
DE AltName: Full=F-box synaptic protein 1;
GN ORFNames=Bm1_56115;
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
CC -!- FUNCTION: Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin
CC ligase complex which may regulate restriction and/or maturation of
CC synapses. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin
CC ligase complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FBXO45/Fsn family. {ECO:0000305}.
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DR EMBL; DS239779; EDP28469.1; -; Genomic_DNA.
DR RefSeq; XP_001902681.1; XM_001902646.1.
DR AlphaFoldDB; A8QGZ7; -.
DR SMR; A8QGZ7; -.
DR STRING; 6279.A8QGZ7; -.
DR EnsemblMetazoa; Bm2404a.1; Bm2404a.1; WBGene00222665.
DR GeneID; 6106105; -.
DR KEGG; bmy:BM_BM2404; -.
DR WBParaSite; Bm2404a.1; Bm2404a.1; WBGene00222665.
DR CTD; 6106105; -.
DR WormBase; Bm2404a; BM02412; WBGene00222665; Bma-fsn-1.
DR HOGENOM; CLU_046756_1_0_1; -.
DR InParanoid; A8QGZ7; -.
DR OMA; YHAWNPN; -.
DR OrthoDB; 938259at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0043005; C:neuron projection; IEA:EnsemblMetazoa.
DR GO; GO:0098793; C:presynapse; IEA:EnsemblMetazoa.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:EnsemblMetazoa.
DR GO; GO:0002020; F:protease binding; IEA:EnsemblMetazoa.
DR GO; GO:0040024; P:dauer larval development; IEA:EnsemblMetazoa.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:EnsemblMetazoa.
DR GO; GO:0030517; P:negative regulation of axon extension; IEA:EnsemblMetazoa.
DR GO; GO:0048681; P:negative regulation of axon regeneration; IEA:EnsemblMetazoa.
DR GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IEA:EnsemblMetazoa.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:1900075; P:positive regulation of neuromuscular synaptic transmission; IEA:EnsemblMetazoa.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:EnsemblMetazoa.
DR GO; GO:0045887; P:positive regulation of synaptic assembly at neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:EnsemblMetazoa.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:EnsemblMetazoa.
DR CDD; cd12907; SPRY_Fbox; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035784; SPRY_FBXO45.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 3: Inferred from homology;
KW Reference proteome; Synapse; Ubl conjugation pathway.
FT CHAIN 1..299
FT /note="F-box/SPRY domain-containing protein 1"
FT /id="PRO_0000383747"
FT DOMAIN 46..94
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT DOMAIN 105..297
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ SEQUENCE 299 AA; 33808 MW; AB356B81B76AB912 CRC64;
MFTEGDKFNQ TVVETDLEQA VDVACRNAQD CCHSKSFTCF TRRMRAVSAA RLPHVVLLAV
FEYLNLKDLA RCMRVCKHWL TVLQYPDSFV WRRLARTVIP DEALNDFSLL SEIPSFKDKL
RAFCYAWNPN DSSKNNYLRP NGFTVHRNPV AQSTDSVRGK IGVNSGIHAW EFTWEGPLGT
VACIGLATKH AALHCQGYVA LLGSDDQSWG WNLVDNQLLH NSKPISPYPH INNPPKYQMG
ERIRMIVDCE QHSMYFEKGS EFLGIAFSRL PPLKLFPAMC AVYGNTEVSM VYIGPPLLG
