ID   FBSP1_CULQU             Reviewed;         258 AA.
AC   B0X9V1;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=F-box/SPRY domain-containing protein 1 {ECO:0000250|UniProtKB:Q9V6L9};
GN   Name=Fsn {ECO:0000250|UniProtKB:Q9V6L9}; ORFNames=CPIJ016123;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000312|EMBL:EDS43303.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000312|EMBL:EDS43303.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required in the presynaptic motoneuron to down-regulate the
CC       levels of wnd and restrain synaptic terminal growth at the
CC       neuromuscular junction (NMJ). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q9V6L9}.
CC   -!- SUBUNIT: Component of an E3 ubiquitin ligase complex composed of hiw
CC       and Fsn. {ECO:0000250|UniProtKB:Q9V6L9}.
CC   -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q9V6L9}.
CC   -!- SIMILARITY: Belongs to the FBXO45/Fsn family. {ECO:0000305}.
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DR   EMBL; DS232551; EDS43303.1; -; Genomic_DNA.
DR   RefSeq; XP_001866423.1; XM_001866388.1.
DR   AlphaFoldDB; B0X9V1; -.
DR   SMR; B0X9V1; -.
DR   STRING; 7176.CPIJ016123-PA; -.
DR   EnsemblMetazoa; XM_001866388.2; XP_001866423.1; LOC6049704.
DR   GeneID; 6049704; -.
DR   KEGG; cqu:CpipJ_CPIJ016123; -.
DR   VEuPathDB; VectorBase:CPIJ016123; -.
DR   VEuPathDB; VectorBase:CQUJHB013350; -.
DR   eggNOG; KOG3953; Eukaryota.
DR   HOGENOM; CLU_046756_1_0_1; -.
DR   InParanoid; B0X9V1; -.
DR   OMA; YHAWNPN; -.
DR   OrthoDB; 1027590at2759; -.
DR   PhylomeDB; B0X9V1; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
DR   GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd12907; SPRY_Fbox; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035784; SPRY_FBXO45.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   3: Inferred from homology;
KW   Neurogenesis; Reference proteome; Synapse; Ubl conjugation pathway.
FT   CHAIN           1..258
FT                   /note="F-box/SPRY domain-containing protein 1"
FT                   /id="PRO_0000383309"
FT   DOMAIN          6..54
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          64..256
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ   SEQUENCE   258 AA;  29186 MW;  6C48CF803C93BF6D CRC64;
     MDDDLTEYAP DIPDNVLELI FSYLKLQDLR NCALVCKSWH RFLSDENNEV WRAQCMQKLS
     PDAFKTDLLS VVPTYKAKLR AFFHAWNPYD CSRHVYIKPN GFTLHRNPVA QSTDGSRGKI
     GFQHGRHAWE VRWEGPLGTV AVVGIATKDA AIQCHGYYAL LGADDQSWGW NLVDNLLLHN
     GDAHGIYPLL NNAPKYKVGE RIRVILDCDD NTLSFEKNYE FLGVAFTDLP DKVFYPTVAA
     VYGNTEISMV YLGPPLDG