ID   FBSP1_DANRE             Reviewed;         291 AA.
AC   Q6NZ03; Q6PH10;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=F-box/SPRY domain-containing protein 1;
DE   AltName: Full=F-box only protein 45;
GN   Name=fbxo45; ORFNames=zgc:65875;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Probable component of a E3 ubiquitin ligase complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FBXO45/Fsn family. {ECO:0000305}.
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DR   EMBL; BC056756; AAH56756.1; -; mRNA.
DR   EMBL; BC066397; AAH66397.2; -; mRNA.
DR   RefSeq; NP_956889.1; NM_200595.1.
DR   AlphaFoldDB; Q6NZ03; -.
DR   SMR; Q6NZ03; -.
DR   STRING; 7955.ENSDARP00000106584; -.
DR   PaxDb; Q6NZ03; -.
DR   Ensembl; ENSDART00000187236; ENSDARP00000157513; ENSDARG00000111553.
DR   GeneID; 393567; -.
DR   KEGG; dre:393567; -.
DR   CTD; 200933; -.
DR   ZFIN; ZDB-GENE-040426-1450; fbxo45.
DR   eggNOG; KOG3953; Eukaryota.
DR   InParanoid; Q6NZ03; -.
DR   OrthoDB; 1027590at2759; -.
DR   PhylomeDB; Q6NZ03; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q6NZ03; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0060386; P:synapse assembly involved in innervation; IBA:GO_Central.
DR   CDD; cd12907; SPRY_Fbox; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035784; SPRY_FBXO45.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..291
FT                   /note="F-box/SPRY domain-containing protein 1"
FT                   /id="PRO_0000383744"
FT   DOMAIN          39..87
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          97..289
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ   SEQUENCE   291 AA;  31298 MW;  16035AD0A6C8CEEF CRC64;
     MSGAVATGGA QSAGLGAAAA GCCSSASGAG SAALLSGGSG IAGRLPSRVL EHIFSYLELM
     DLLNCSLVCW HWNNCLSDEN SEVWRSLCAR SLSDEAMRSD ILCNLASYKG KLKSFQHALS
     SHDCSRNVYI KKNGFTLHRN PIAQSTDGAR GKIGFSEGRH AWEIWWEGPL GTVAVIGIAT
     KRAPMQCQGY VALLGSDDQS WGWNLVDNNL LHNGEVNGNF PQCNNAPKYQ IGERIRVILD
     MDDKTLAFER GFEFLGVAFR GLPKTCLFPA VSAVYGNTEV TMVYLGRPLD G