FBSP1_DROER
ID FBSP1_DROER Reviewed; 255 AA.
AC B3NRP1;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=F-box/SPRY domain-containing protein 1 {ECO:0000250|UniProtKB:Q9V6L9};
GN Name=Fsn {ECO:0000250|UniProtKB:Q9V6L9}; ORFNames=GG22511;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1] {ECO:0000312|EMBL:EDV56193.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV56193.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required in the presynaptic motoneuron to down-regulate the
CC levels of wnd and restrain synaptic terminal growth at the
CC neuromuscular junction (NMJ). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:Q9V6L9}.
CC -!- SUBUNIT: Component of an E3 ubiquitin ligase complex composed of hiw
CC and Fsn. {ECO:0000250|UniProtKB:Q9V6L9}.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q9V6L9}.
CC -!- SIMILARITY: Belongs to the FBXO45/Fsn family. {ECO:0000305}.
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DR EMBL; CH954179; EDV56193.1; -; Genomic_DNA.
DR RefSeq; XP_001975793.1; XM_001975757.2.
DR AlphaFoldDB; B3NRP1; -.
DR SMR; B3NRP1; -.
DR STRING; 7220.FBpp0141057; -.
DR EnsemblMetazoa; FBtr0142565; FBpp0141057; FBgn0114682.
DR eggNOG; KOG3953; Eukaryota.
DR HOGENOM; CLU_046756_1_0_1; -.
DR OMA; YHAWNPN; -.
DR OrthoDB; 1027590at2759; -.
DR PhylomeDB; B3NRP1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
DR GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd12907; SPRY_Fbox; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035784; SPRY_FBXO45.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 3: Inferred from homology;
KW Neurogenesis; Synapse; Ubl conjugation pathway.
FT CHAIN 1..255
FT /note="F-box/SPRY domain-containing protein 1"
FT /id="PRO_0000383311"
FT DOMAIN 3..51
FT /note="F-box"
FT /evidence="ECO:0000255"
FT DOMAIN 61..253
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ SEQUENCE 255 AA; 28846 MW; 204E537A1C894F2B CRC64;
MVDPVAALCN YNVLEVIFSY LELEDLSHCS QVCKSWYHFL NDENSDVWRW HCLNKLPKEA
LKSDLLSSVS TYKTKLRAYF HAWSPNDCSR NVYIKPNGFT LHRNPVAQST DAARGKIGFR
HGRHTWEVIW EGPLGTVAVI GISTKEAALQ CHGYVALLGS DDQSWGWNLV ENHLLHNGDM
QGSYPLLNNA PKYQVGERIR VILDCEDNTL SFEKNYEFLG VAFRGLPDKK LYPTVSAVYG
NTEVSMVYLG TPLDG
