ID   FBSP1_DROVI             Reviewed;         252 AA.
AC   B4LMQ3;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=F-box/SPRY domain-containing protein 1 {ECO:0000250|UniProtKB:Q9V6L9};
GN   Name=Fsn {ECO:0000250|UniProtKB:Q9V6L9}; ORFNames=GJ21788;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000312|EMBL:EDW60994.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000312|EMBL:EDW60994.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required in the presynaptic motoneuron to down-regulate the
CC       levels of wnd and restrain synaptic terminal growth at the
CC       neuromuscular junction (NMJ). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q9V6L9}.
CC   -!- SUBUNIT: Component of an E3 ubiquitin ligase complex composed of hiw
CC       and Fsn. {ECO:0000250|UniProtKB:Q9V6L9}.
CC   -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q9V6L9}.
CC   -!- SIMILARITY: Belongs to the FBXO45/Fsn family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH940648; EDW60994.1; -; Genomic_DNA.
DR   RefSeq; XP_002049801.1; XM_002049765.2.
DR   AlphaFoldDB; B4LMQ3; -.
DR   SMR; B4LMQ3; -.
DR   STRING; 7244.FBpp0236205; -.
DR   EnsemblMetazoa; FBtr0237713; FBpp0236205; FBgn0208906.
DR   GeneID; 6626225; -.
DR   KEGG; dvi:6626225; -.
DR   eggNOG; KOG3953; Eukaryota.
DR   HOGENOM; CLU_046756_1_0_1; -.
DR   InParanoid; B4LMQ3; -.
DR   OMA; YHAWNPN; -.
DR   OrthoDB; 1027590at2759; -.
DR   PhylomeDB; B4LMQ3; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR   GO; GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblMetazoa.
DR   GO; GO:0045495; C:pole plasm; IEA:EnsemblMetazoa.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:EnsemblMetazoa.
DR   GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; ISS:UniProtKB.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd12907; SPRY_Fbox; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035784; SPRY_FBXO45.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   3: Inferred from homology;
KW   Neurogenesis; Reference proteome; Synapse; Ubl conjugation pathway.
FT   CHAIN           1..252
FT                   /note="F-box/SPRY domain-containing protein 1"
FT                   /id="PRO_0000383318"
FT   DOMAIN          1..48
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          58..250
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ   SEQUENCE   252 AA;  28624 MW;  5CBFAD1B743C8777 CRC64;
     MVDPLCNYNV LEAIFSYLEL NDLYRCSQVC KSWYHFLNDE NSDVWRWHCL RKLPKESVKS
     DLLASVSTYK TKLRAYLHAW SPNDCSRNVY IKPNGFTLHR NPVAQSTDAA RGKIGFRQGR
     HAWEVIWEGP LGTVAVIGIS TKEAALQCHG YVALLGSDDQ SWGWNLVENH LLHNGDMQGN
     YPLLNNAPKY QVGERIRVIL DCDDNTLSFE KNYEFLGVAF RGLPDKKLYP TVSAVYGNTE
     VSMVYLGTPL DG