ID   FBSP1_XENLA             Reviewed;         280 AA.
AC   Q7ZXY1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=F-box/SPRY domain-containing protein 1;
DE   AltName: Full=F-box only protein 45;
GN   Name=fbxo45;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Probable component of a E3 ubiquitin ligase complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FBXO45/Fsn family. {ECO:0000305}.
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DR   EMBL; BC044070; AAH44070.1; -; mRNA.
DR   RefSeq; NP_001080739.1; NM_001087270.1.
DR   AlphaFoldDB; Q7ZXY1; -.
DR   SMR; Q7ZXY1; -.
DR   DNASU; 380431; -.
DR   GeneID; 380431; -.
DR   CTD; 380431; -.
DR   Xenbase; XB-GENE-6078307; fbxo45.S.
DR   OMA; WEITWIE; -.
DR   OrthoDB; 1027590at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 380431; Expressed in spleen and 19 other tissues.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd12907; SPRY_Fbox; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035784; SPRY_FBXO45.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..280
FT                   /note="F-box/SPRY domain-containing protein 1"
FT                   /id="PRO_0000383745"
FT   DOMAIN          27..76
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          86..278
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..28
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  30824 MW;  B4BF621A32902DD0 CRC64;
     MAAAINAAVP SPPVAPSAPP PPPPPLGQAS DRFPSLVLEL VFSYLDLPDL RSCGLVCKRW
     YRCLHGDKNS DVWRSLCCRI VSEEALRTDI LCNLRTYKAK VRAFQHGLSS SDCSRNVFIK
     KNGFTLHRNP IAQSTDGART KIGFSEGRHA WEVWWEGPLG TVAVIGIATK QAPMQCQGYV
     ALLGSDDQSW GWNLVDNNLL HNGEVNGSFP QCNNAPKYQI GERIRVILDM EDKTLAFERG
     YEYLGVAFRG LPKACLYPAV SAVYGNTEVT LVYLGKPLDG