ID   FBSP1_XENTR             Reviewed;         282 AA.
AC   B4F739;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=F-box/SPRY domain-containing protein 1;
DE   AltName: Full=F-box only protein 45;
GN   Name=fbxo45;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-282 (ISOFORM 1).
RC   TISSUE=Embryo;
RA   Richardson P., Lucas S., Rokhsar D., Detter J.C., Ng D.C., Brokstein P.,
RA   Lindquist E.A.;
RT   "DOE Joint Genome Institute Xenopus tropicalis EST project.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Probable component of a E3 ubiquitin ligase complex.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=B4F739-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=B4F739-2; Sequence=VSP_038044;
CC   -!- SIMILARITY: Belongs to the FBXO45/Fsn family. {ECO:0000305}.
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DR   EMBL; BC168120; AAI68120.1; -; mRNA.
DR   EMBL; CX453823; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001135592.1; NM_001142120.1. [B4F739-2]
DR   RefSeq; XP_012825639.1; XM_012970185.2. [B4F739-1]
DR   AlphaFoldDB; B4F739; -.
DR   SMR; B4F739; -.
DR   PaxDb; B4F739; -.
DR   Ensembl; ENSXETT00000072831; ENSXETP00000085266; ENSXETG00000040149.
DR   GeneID; 100216147; -.
DR   KEGG; xtr:100216147; -.
DR   CTD; 200933; -.
DR   Xenbase; XB-GENE-972343; fbxo45.
DR   eggNOG; KOG3953; Eukaryota.
DR   HOGENOM; CLU_046756_1_0_1; -.
DR   InParanoid; B4F739; -.
DR   OMA; YHAWNPN; -.
DR   OrthoDB; 1027590at2759; -.
DR   PhylomeDB; B4F739; -.
DR   TreeFam; TF312822; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000040149; Expressed in 4-cell stage embryo and 12 other tissues.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0060386; P:synapse assembly involved in innervation; IBA:GO_Central.
DR   CDD; cd12907; SPRY_Fbox; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035784; SPRY_FBXO45.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..282
FT                   /note="F-box/SPRY domain-containing protein 1"
FT                   /id="PRO_0000383746"
FT   DOMAIN          29..78
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          88..280
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..31
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         222..282
FT                   /note="IGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKTCLYPAVSAVYGNTEVTL
FT                   VYLGKPLDG -> LLQRNRMLDIYFHYVHYLVLVQEITESVGKNR (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_038044"
SQ   SEQUENCE   282 AA;  30984 MW;  F08638BDE8D8E837 CRC64;
     MAAAAINAAA PPPPVAPTAP PPPPPPPLSQ ASGRLPSRVL ELVFSYLDLP DLRSCGLVCK
     HWYRCLHGDE NSEVWRSLCG RIVSEEALRT DILCNLPTYK AKMRAFQHGF SSSDCSRNVY
     IKKNGFTLHR NPIAQSTDGA RTKIGFSEGR HAWEVWWEGP LGTVAVIGIA TKRAPMQCQG
     YVALLGSDDQ SWGWNLVDNN LLHNGEVNGS FPQCNNAPKY QIGERIRVIL DMEDKTLAFE
     RGYEFLGVAF RGLPKTCLYP AVSAVYGNTE VTLVYLGKPL DG